Frontiers in Anti-infective Drug Discovery

Volume 1

by

Atta-ur-Rahman, M. Iqbal Choudhary

DOI: 10.2174/97816080515881100101
eISBN: 978-1-60805-158-8, 2010
ISBN: 978-1-60805-583-8
ISSN: 1879-663X (Print)

  
  


Indexed in: Chemical Abstracts, EMBASE

“Frontiers in Anti-Infective Drug Discovery” is an eBook series devoted to publishing the latest and the most important advances in An...[view complete introduction]
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Table of Contents

Preface

- Pp. i

Atta-ur-Rahman and M. Iqbal Choudhary

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Contributors

- Pp. ii-vi (3)

Bentham Science Publishers

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Strategies for Effective Naked-DNA Vaccination Against Infectious Diseases

- Pp. 1-16 (16)

Pieranna Chiarella, Emanuela Massi, Mariangela De Robertis, Vito M. Fazio and Emanuela Signori

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Light Activated Compounds as Patented Antimicrobial Agents

- Pp. 17-48 (32)

David Andrew Phoenix and Frederick Harris

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Proteases and Kinases: Attractive Targets for Combating Infectious Diseases

- Pp. 49-69 (21)

Mona Arabshahi, Usha Bughani, Surya N. Vangapandu, Ritu Aneja, Ramesh Chandra, Daniel Kalman and Harish Joshi

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Antibacterial Therapy in the Elderly

- Pp. 70-82 (13)

Ayman M. Noreddin and Walid F. El-Khatib

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SARS Coronavirus Anti-Infectives

- Pp. 83-106 (24)

Tommy R. Tong

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Probiotics as Drugs Against Human Gastrointestinal Pathogens

- Pp. 107-123 (17)

Yolanda Sanz, Inmaculada Nadal and Ester Sanchez

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Insights into the Treatment of Helicobacter pylori Infection

- Pp. 124-137 (14)

Campo Salvatore Maria Antonio, Hassan Cesare, Burza Maria Antonietta, Ridola Lorenzo, Cristofari Francesca, Morini Sergio and Zullo

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Inhibitors of Bacterial Efflux Pumps as Adjuvants in Antibacterial Therapy and Diagnostic Tools for Detection of Resistance by E

- Pp. 138-175 (38)

Francoise Van Bambeke, Jean-Marie Pages and Ving J. Lee

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Drugs Candidates in Advanced Clinical Trials Against Tuberculosis

- Pp. 176-201 (26)

Marcus Vinicius Nora de Souza, Marcelle de Lima Ferreira and Raoni Schroeder B. Goncalves

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Drug Effects on Drug Targets: Inhibition of Enzymes by Neuroleptics, Antimycotics, Antibiotics and Other Drugs on Human Pathogen

- Pp. 202-226 (25)

Raul N. Ondarza

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Macrophage Inflammatory Protein 1 and CCR5 as Potential Therapeutic Targets for HIV Infection and Acquired Immunodeficiency Synd

- Pp. 227-237 (11)

Tsuyoshi Kasama, Ryo Takahashi, Michihito Sato and Kuninobu Wakabayashi

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Small-Molecule Inhibitors of Raf for Treatment of Malignant Diseases

- Pp. 238-250 (13)

Li Li, Shuhong Wu, Wei Guo and Bingliang Fang

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Tigecycline: A New Treatment Choice Against Acinetobacter baumannii

- Pp. 251-260 (10)

Virginia Boso-Ribelles, Eva Roma-Sanchez, Jorge Carmena, Cristina Caceres and Daniel Bautista

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Cefepime and its Role in Pediatric Infections

- Pp. 261-268 (8)

Sukhbir K. Shahid

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Antibacterial Properties of Organosulfur Anti-Infectives: A Review of Patent Literature 1999-2009

- Pp. 269-278 (10)

Monika I. Konaklieva and Balbina J. Plotkin

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A Review of the Carbapenems in Clinical Use and Clinical Trials

- Pp. 279-293 (15)

Tze Shien Lo, Justin M. Welch, Augusto M. Alonto and Eileen Anne R. Vicaldo-Alonto

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Anti-Infective Quinone Derivatives of Recent Patents

- Pp. 294-322 (29)

Junko Koyama

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Targets and Patented Drugs for Chemotherapy of Chagas Disease

- Pp. 323-408 (86)

Vilma G. Duschak and Alicia S. Couto

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Recent Patents on Development of Nucleic Acid-Based Antiviral Drugs against Seasonal and Pandemic Influenza Virus Infections

- Pp. 409-425 (17)

Edward G. Saravolac and Jonathan P. Wong

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Author Index to Volume 1

- Pp. 426- (1)

Atta-ur-Rahman and M. Iqbal Choudhary

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Preface

The scientists invited to contribute short reviews to this first volume of book series, “Frontiers in Anti-Infective Drug Discovery” were selected on the basis of their own original contributions in this important field of health research. The chapters contain in this volume are the updated version of articles published in Recent Patents on Anti-Infective Drug Discovery. The reviews cover key aspects of infections caused by a variety of organisms.

With the enhanced understanding of diseases at cellular and molecular levels, the search for anti-infective agents is now more rational and strategically based on new tools and novel techniques. Most of the reviews address the molecular mechanisms of infections and development of inhibitors of these mechanisms. Several groups of existing anti-infective agents have also been reviewed. The topics range from vaccines to clinical trials of exploratory drugs, treatment by age-old anti-infective agents, and reviews on recent patents. Each review is well-written and extensively referenced. We hope that volume 1 of this series will be welcomed by of students and researchers and that it will lead to a broader understanding of the current status of this subject.

We wish to express our profound gratitude to all authors for their excellent contributions. We are also grateful to the management and the staff of the Bentham Science Publishers (the Netherlands), especially Mr. Mahmood Alam (Managing Director), Ms. Samina Khan (Senior Manager), Ms. Taqdees Malik (Assistant Manager) and Ms. Sadaf Idrees Khan (Composer), for their help in compilation of the first volume of this important series of books.

Prof. Dr. Atta-ur-Rahman, FRS
Prof. Dr. M. Iqbal Choudhary
Editors

List of Contributors

Editor(s):
Prof. Dr. Atta-ur-Rahman FRS
University of Karachi
Pakistan



Prof. Dr. M. Iqbal Choudhary
University of Karachi
Pakistan





Contributor(s):
Pieranna Chiarella
Laboratory of Molecular Medicine and Biotechnology, CIR
Campus Bio-Medico University of Rome
Via Alvaro del Portillo
Rome, 21 - 00128
Italy

Institute of Neurobiology and Molecular Medicine, CNR, Via Fosso del Cavaliere
Rome, 100 - 00133
Italy

Laboratory of Molecular Medicine and Biotechnology, CIR, Campus Bio-Medico University of Rome
Via Alvaro del Portillo 21 - 00128 Institute of Neurobiology and Molecular Medicine
CNR, Via Fosso del Cavaliere
Rome, 100 - 00133
Italy



Emanuela Massi
Laboratory of Molecular Medicine and Biotechnology, CIR
Campus Bio-Medico University of Rome
Via Alvaro del Portillo 21
Rome, 00128
Italy

Institute of Neurobiology and Molecular Medicine, CNR
Via Fosso del Cavaliere 100
Rome, 00133
Italy



Mariangela De Robertis
Laboratory of Molecular Medicine and Biotechnology, CIR
Campus Bio-Medico University of Rome
Via Alvaro del Portillo 21
Rome, 00128
Italy

Institute of Neurobiology and Molecular Medicine, CNR
Via Fosso del Cavaliere 100
Rome, 00133
Italy



Vito M. Fazio
Laboratory of Molecular Medicine and Biotechnology, CIR
Campus Bio-Medico University of Rome
Via Alvaro del Portillo 21
Rome, 00128
Italy

Laboratory of Oncology, Research Department
IRCCS H "Casa Sollievo della Sofferenza"
S. Giovanni Rotondo (FG), 71013
Italy



Emanuela Signori
Institute of Neurobiology and Molecular Medicine, CNR
Via Fosso del Cavaliere 100
Rome, 00133
Italy



David Andrew Phoenix
Deputy Vice Chancellor
University of Central Lancashire PR1 2HE
Preston
UK



Frederick Harris
School of Forensic and Investigative Sciences
University of Central Lancashire
Preston, PR1 2HE
UK



Mona Arabshahi
Department of Cell Biology
Emory University School of Medicine
Atlanta
GA
USA



Usha Bughani
Department of Cell Biology
Emory University School of Medicine
Atlanta
GA
USA



Surya N. Vangapandu
Department of Cell Biology
Emory University School of Medicine
Atlanta
GA
USA



Ritu Aneja
Department of Cell Biology
Emory University School of Medicine
Atlanta
GA
USA



Ramesh Chandra
Department of Chemistry and Dr. B. R. Ambedkar Center for Biomedical Research
University of Delhi
Delhi
India



Daniel Kalman
Department of Pathology
Emory University School of Medicine
Atlanta
GA
USA



Harish Joshi
Department of Cell Biology
Emory University School of Medicine
Atlanta
GA
USA



Ayman M. Noreddin
School of Pharmacy, Hampton University
Hampton Roads Bridge Tunnel
Hampton
VA, 23668
USA



Walid F. El-Khatib
College of Pharmacy, University of Minnesota
4-101 Hanson Hall 1925 Fourth Street South
Minneapolis
MN, 55455
USA



Tommy R. Tong
Department of Pathology
Montefiore Medical Center
600 E 233 Street, Bronx
New York, 10466
USA



Yolanda Sanz
Instituto de Agroquímica y Tecnología de los Alimentos (CSIC)
P.O. Box 73 4610 Burjassot
Valencia, 46100
Spain



Inmaculada Nadal
Instituto de Agroquímica y Tecnología de los Alimentos (CSIC)
P.O. Box 73 46100 Burjassot
Valencia, 46100
Spain



Ester Sánchez
Instituto de Agroquímica y Tecnología de los Alimentos (CSIC)
P.O. Box 73 46100, Burjassot
Valencia, 46100
Spain



Campo S. M. Antonio
Gastroenterology and Digestive Endoscopy
Nuovo Regina Margherita” Hospital
Rome
Italy



Hassan Cesare
Gastroenterology and Digestive Endoscopy
“Nuovo Regina Margherita” Hospital
Rome
Italy



Burza Maria Antonietta
Gastroenterology and Digestive Endoscopy
“Nuovo Regina Margherita” Hospital
Rome
Italy



Ridola Lorenzo
Gastroenterology and Digestive Endoscopy
“Nuovo Regina Margherita” Hospital
Rome
Italy



Cristofari Francesca
Gastroenterology and Digestive Endoscopy
“Nuovo Regina Margherita” Hospital
Rome
Italy



Morini Sergio
Gastroenterology and Digestive Endoscopy
“Nuovo Regina Margherita” Hospital
Rome
Italy



Zullo Angelo
Gastroenterology and Digestive Endoscopy
“Nuovo Regina Margherita” Hospital
Rome
Italy



Françoise Van Bambeke
Unité de Pharmacologie Cellulaire et Moleculaire
Université Catholique de Louvain
Brussels
Belgium



Jean-Marie Pagès
EA2197 Enveloppe Bactérienne, Perméabilité et Antibiotiques
Faculté de Médecine, Université de la Méditerranée
Marseille
France



Ving J. Lee
Adesis, Inc., New Castle, DE 19720, Limerick BioPharma, Inc.
South San Francisco
CA, 94080
USA



Marcus Vinícius Nora de Souza
Instituto de Tecnologia em Fármacos-Far-Manguinhos
Rua Sizenando Nabuco 100, Manguinhos
Rio de Janeiro-RJ, 21041-250
Brazil



Marcelle de Lima Ferreira
Instituto de Tecnologia em Fármacos-Far-Manguinhos
Rua Sizenando Nabuco, 100, Manguinhos
Rio de Janeiro-RJ, 21041-250
Brazil



Raoni Schroeder B. Gonçalves
Instituto de Tecnologia em Fármacos-Far-Manguinhos
Rua Sizenando Nabuco, 100, Manguinhos
Rio de Janeiro-RJ, 221041-250
Brazil



Raúl N. Ondarza
Department of Biochemistry
Faculty of Medicine, National Autonomous University of Mexico (UNAM)
University City
Mexico , 04510
USA

Center of Research on Infectious Diseases, National Institute of Public Health
Cuernavaca, Morelos
Mexico , 62508
USA

Center for Marine Biotechnology and Biomedicine
Scripps Institution of Oceanography, University of California, San Diego (UCSD)
La Jolla
CA, 92093-0204
USA



Tsuyoshi Kasama
Division of Rheumatology, Department of Medicine
Showa University School of Medicine
1-5-8 Hatanodai, Shinagawa-ku
Tokyo, 142-8666
Japan



Ryo Takahashi
Division of Rheumatology, Department of Medicine
Showa University School of Medicine
1-5-8 Hatanodai, Shinagawa-ku
Tokyo, 142-8666
Japan



Michihito Sato
Division of Rheumatology, Department of Medicine
Showa University School of Medicine
1-5-8 Hatanodai, Shinagawa-ku
Tokyo, 142-8666
Japan



Kuninobu Wakabayashi
Division of Rheumatology, Department of Medicine
Showa University School of Medicine
1-5-8 Hatanodai, Shinagawa-ku
Tokyo, 142-8666
Japan



Li Li
Department of Laboratory Medicine
First Hospital of Shanghai
Shanghai
China



Shuhong Wu
Department of Thoracic and Cardiovascular Surgery
The University of Texas M. D. Anderson Cancer Center, Houston
Texas , 77030
USA



Wei Guo
Department of Thoracic and Cardiovascular Surgery
The University of Texas M. D. Anderson Cancer Center Houston
Texas, 77030
USA



Bingliang Fang
Department of Thoracic and Cardiovascular Surgery
The University of Texas M. D. Anderson Cancer Center, Houston
Texas, 77030
USA



Virginia Bosó-Ribelles
Pharmacy Department
Hospital La Fe
Valencia
Spain



Eva Romá-Sánchez
Pharmacy Department
Hospital La Fe
Valencia
Spain



Jorge Carmena
Infectious Diseases Department
Hospital Dr. Peset
Valencia
Spain



Cristina Cáceres
Infectious Diseases Department
Hospital Dr. Peset
Valencia
Spain



Daniel Bautista
Preventive Medicine Department
Hospital Dr. Peset
Valencia
Spain



Sukhbir K. Shahid
Consultant Pediatrician and Neonatologist
Mumbai, 400 077
India



Monika I. Konaklieva
Department of Chemistry
American University
4400 Massachusetts Avenue, NW
Washington
DC, 20016-8014
USA



Balbina J. Plotkin
Department of Microbiology and Immunology
CCOM, Midwestern University
555 31 St.
Downers Grove
IL, 60515
USA



Tze Shien Lo
Section of Infectious Diseases
Veterans Affairs Medical Center
Fargo
ND
USA



Justin M. Welch
Pharmacy Department
Veterans Affairs Medical Center
Fargo
ND
USA



Augusto M. Alonto
Section of Infectious Diseases
MeritCare Medical Center
Fargo
ND
USA



Eileen Anne R. Vicaldo-Alonto
Department of Internal Medicine
University of North Dakota School of Medicine & Health Sciences
Fargo
ND
USA



Junko Koyama
Faculty of Pharmaceutical Sciences, Kobe Pharmaceutical University
Higashinada-ku
Kobe, 658-8558
Japan



Vilma G. Duschak
Instituto Nacional de Parasitología “Dr. Mario Fatala Chabén”, ANLIS-Malbrán
Ministerio de Salud. Av. Paseo Colon 568 (1063)
Buenos Aires
Argentina



Alicia S. Couto
CIHIDECAR (CONICET) Departamento de Química Orgánica
Facultad de Ciencias Exactas Naturales
Universidad de Buenos Aires
Buenos Aires
CP, 1428
Argentina



Edward G. Saravolac
Formulation Technology Consulting
3 Essex St., Footscray
Victoria, 3011
Australia



Jonathan P. Wong
Defence R&D Canada - Suffield, Biotechnology Section
Box 4000 Main Station, Medicine Hat
Alberta, T1A 8K6
Canada





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