Frontiers in Anti-infective Drug Discovery

Volume 1

by

Atta-ur-Rahman, M. Iqbal Choudhary

DOI: 10.2174/97816080515881100101
eISBN: 978-1-60805-158-8, 2010
ISBN: 978-1-60805-583-8
ISSN: 1879-663X

  
  


Indexed in: Chemical Abstracts

“Frontiers in Anti-Infective Drug Discovery” is an eBook series devoted to publishing the latest and the most important advances in An...[view complete introduction]
PDF US $
- Single user / Non-Library usage: 44
- Multi user / Library usage: 176
Print-On-Demand (P.O.D): *191
Special Offer for Single user / Non-Library usage (PDF + P.O.D): *213

*(Excluding Mailing and Handling)
Purchase: Book Chapters

Table of Contents

Preface , Pp. i

Atta-ur-Rahman and M. Iqbal Choudhary
Download Free

Contributors , Pp. ii-vi (3)

Bentham Science Publishers
Download Free

Strategies for Effective Naked-DNA Vaccination Against Infectious Diseases , Pp. 1-16 (16)

Pieranna Chiarella, Emanuela Massi, Mariangela De Robertis, Vito M. Fazio and Emanuela Signori
Purchase Chapter

Light Activated Compounds as Patented Antimicrobial Agents , Pp. 17-48 (32)

David Andrew Phoenix and Frederick Harris
Purchase Chapter

Proteases and Kinases: Attractive Targets for Combating Infectious Diseases , Pp. 49-69 (21)

Mona Arabshahi, Usha Bughani, Surya N. Vangapandu, Ritu Aneja, Ramesh Chandra, Daniel Kalman and Harish Joshi
Purchase Chapter

Antibacterial Therapy in the Elderly , Pp. 70-82 (13)

Ayman M. Noreddin and Walid F. El-Khatib
Purchase Chapter

SARS Coronavirus Anti-Infectives , Pp. 83-106 (24)

Tommy R. Tong
Purchase Chapter

Probiotics as Drugs Against Human Gastrointestinal Pathogens , Pp. 107-123 (17)

Yolanda Sanz, Inmaculada Nadal and Ester Sanchez
Purchase Chapter

Insights into the Treatment of Helicobacter pylori Infection , Pp. 124-137 (14)

Campo Salvatore Maria Antonio, Hassan Cesare, Burza Maria Antonietta, Ridola Lorenzo, Cristofari Francesca, Morini Sergio and Zullo
Purchase Chapter

Inhibitors of Bacterial Efflux Pumps as Adjuvants in Antibacterial Therapy and Diagnostic Tools for Detection of Resistance by E , Pp. 138-175 (38)

Francoise Van Bambeke, Jean-Marie Pages and Ving J. Lee
Purchase Chapter

Drugs Candidates in Advanced Clinical Trials Against Tuberculosis , Pp. 176-201 (26)

Marcus Vinicius Nora de Souza, Marcelle de Lima Ferreira and Raoni Schroeder B. Goncalves
Purchase Chapter

Drug Effects on Drug Targets: Inhibition of Enzymes by Neuroleptics, Antimycotics, Antibiotics and Other Drugs on Human Pathogen , Pp. 202-226 (25)

Raul N. Ondarza
Purchase Chapter

Macrophage Inflammatory Protein 1 and CCR5 as Potential Therapeutic Targets for HIV Infection and Acquired Immunodeficiency Synd , Pp. 227-237 (11)

Tsuyoshi Kasama, Ryo Takahashi, Michihito Sato and Kuninobu Wakabayashi
Download Free

Small-Molecule Inhibitors of Raf for Treatment of Malignant Diseases , Pp. 238-250 (13)

Li Li, Shuhong Wu, Wei Guo and Bingliang Fang
Download Free

Tigecycline: A New Treatment Choice Against Acinetobacter baumannii , Pp. 251-260 (10)

Virginia Boso-Ribelles, Eva Roma-Sanchez, Jorge Carmena, Cristina Caceres and Daniel Bautista
Purchase Chapter

Cefepime and its Role in Pediatric Infections , Pp. 261-268 (8)

Sukhbir K. Shahid
Purchase Chapter

Antibacterial Properties of Organosulfur Anti-Infectives: A Review of Patent Literature 1999-2009 , Pp. 269-278 (10)

Monika I. Konaklieva and Balbina J. Plotkin
Purchase Chapter

A Review of the Carbapenems in Clinical Use and Clinical Trials , Pp. 279-293 (15)

Tze Shien Lo, Justin M. Welch, Augusto M. Alonto and Eileen Anne R. Vicaldo-Alonto
Purchase Chapter

Anti-Infective Quinone Derivatives of Recent Patents , Pp. 294-322 (29)

Junko Koyama
Purchase Chapter

Targets and Patented Drugs for Chemotherapy of Chagas Disease , Pp. 323-408 (86)

Vilma G. Duschak and Alicia S. Couto
Purchase Chapter

Recent Patents on Development of Nucleic Acid-Based Antiviral Drugs against Seasonal and Pandemic Influenza Virus Infections , Pp. 409-425 (17)

Edward G. Saravolac and Jonathan P. Wong
Purchase Chapter

Author Index to Volume 1 , Pp. 426- (1)

Atta-ur-Rahman and M. Iqbal Choudhary
Download Free

Preface

The scientists invited to contribute short reviews to this first volume of book series, “Frontiers in Anti-Infective Drug Discovery” were selected on the basis of their own original contributions in this important field of health research. The chapters contain in this volume are the updated version of articles published in Recent Patents on Anti-Infective Drug Discovery. The reviews cover key aspects of infections caused by a variety of organisms.

With the enhanced understanding of diseases at cellular and molecular levels, the search for anti-infective agents is now more rational and strategically based on new tools and novel techniques. Most of the reviews address the molecular mechanisms of infections and development of inhibitors of these mechanisms. Several groups of existing anti-infective agents have also been reviewed. The topics range from vaccines to clinical trials of exploratory drugs, treatment by age-old anti-infective agents, and reviews on recent patents. Each review is well-written and extensively referenced. We hope that volume 1 of this series will be welcomed by of students and researchers and that it will lead to a broader understanding of the current status of this subject.

We wish to express our profound gratitude to all authors for their excellent contributions. We are also grateful to the management and the staff of the Bentham Science Publishers (the Netherlands), especially Mr. Mahmood Alam (Managing Director), Ms. Samina Khan (Senior Manager), Ms. Taqdees Malik (Assistant Manager) and Ms. Sadaf Idrees Khan (Composer), for their help in compilation of the first volume of this important series of books.

Prof. Dr. Atta-ur-Rahman, FRS
Prof. Dr. M. Iqbal Choudhary
Editors

List of Contributors

Editor(s):
Prof. Dr. Atta-ur-Rahman FRS
University of Karachi
Pakistan


Prof. Dr. M. Iqbal Choudhary
University of Karachi
Pakistan




Contributor(s):
Pieranna Chiarella
Laboratory of Molecular Medicine and Biotechnology, CIR
Campus Bio-Medico University of Rome
Via Alvaro del Portillo
Via Alvaro del Portillo 21 - 00128 Institute of Neurobiology and Molecular Medicine
CNR, Via Fosso del Cavaliere
Rome, 21 - 00128
Italy


Emanuela Massi
Laboratory of Molecular Medicine and Biotechnology, CIR
Campus Bio-Medico University of Rome
Via Alvaro del Portillo 21
Via Fosso del Cavaliere 100
Rome, 00128
Italy


Mariangela De Robertis
Laboratory of Molecular Medicine and Biotechnology, CIR
Campus Bio-Medico University of Rome
Via Alvaro del Portillo 21
Via Fosso del Cavaliere 100
Rome, 00128
Italy


Vito M. Fazio
Laboratory of Molecular Medicine and Biotechnology, CIR
Campus Bio-Medico University of Rome
Via Alvaro del Portillo 21
IRCCS H "Casa Sollievo della Sofferenza"
Rome, 00128
Italy


Emanuela Signori
Institute of Neurobiology and Molecular Medicine, CNR
Via Fosso del Cavaliere 100
Rome, 00133
Italy


David Andrew Phoenix
Deputy Vice Chancellor
University of Central Lancashire PR1 2HE
Preston
UK


Frederick Harris
School of Forensic and Investigative Sciences
University of Central Lancashire
Preston, PR1 2HE
UK


Mona Arabshahi
Department of Cell Biology
Emory University School of Medicine
Atlanta
GA
USA


Usha Bughani
Department of Cell Biology
Emory University School of Medicine
Atlanta
GA
USA


Surya N. Vangapandu
Department of Cell Biology
Emory University School of Medicine
Atlanta
GA
USA


Ritu Aneja
Department of Cell Biology
Emory University School of Medicine
Atlanta
GA
USA


Ramesh Chandra
Department of Chemistry and Dr. B. R. Ambedkar Center for Biomedical Research
University of Delhi
Delhi
India


Daniel Kalman
Department of Pathology
Emory University School of Medicine
Atlanta
GA
USA


Harish Joshi
Department of Cell Biology
Emory University School of Medicine
Atlanta
GA
USA


Ayman M. Noreddin
School of Pharmacy, Hampton University
Hampton Roads Bridge Tunnel
Hampton
VA, 23668
USA


Walid F. El-Khatib
College of Pharmacy, University of Minnesota
4-101 Hanson Hall 1925 Fourth Street South
Minneapolis
MN, 55455
USA


Tommy R. Tong
Department of Pathology
Montefiore Medical Center
600 E 233 Street, Bronx
New York, 10466
USA


Yolanda Sanz
Instituto de Agroquímica y Tecnología de los Alimentos (CSIC)
P.O. Box 73 4610 Burjassot
Valencia, 46100
Spain


Inmaculada Nadal
Instituto de Agroquímica y Tecnología de los Alimentos (CSIC)
P.O. Box 73 46100 Burjassot
Valencia, 46100
Spain


Ester Sánchez
Instituto de Agroquímica y Tecnología de los Alimentos (CSIC)
P.O. Box 73 46100, Burjassot
Valencia, 46100
Spain


Campo S. M. Antonio
Gastroenterology and Digestive Endoscopy
Nuovo Regina Margherita” Hospital
Rome
Italy


Hassan Cesare
Gastroenterology and Digestive Endoscopy
“Nuovo Regina Margherita” Hospital
Rome
Italy


Burza Maria Antonietta
Gastroenterology and Digestive Endoscopy
“Nuovo Regina Margherita” Hospital
Rome
Italy


Ridola Lorenzo
Gastroenterology and Digestive Endoscopy
“Nuovo Regina Margherita” Hospital
Rome
Italy


Cristofari Francesca
Gastroenterology and Digestive Endoscopy
“Nuovo Regina Margherita” Hospital
Rome
Italy


Morini Sergio
Gastroenterology and Digestive Endoscopy
“Nuovo Regina Margherita” Hospital
Rome
Italy


Zullo Angelo
Gastroenterology and Digestive Endoscopy
“Nuovo Regina Margherita” Hospital
Rome
Italy


Françoise Van Bambeke
Unité de Pharmacologie Cellulaire et Moleculaire
Université Catholique de Louvain
Brussels
Belgium


Jean-Marie Pagès
EA2197 Enveloppe Bactérienne, Perméabilité et Antibiotiques
Faculté de Médecine, Université de la Méditerranée
Marseille
France


Ving J. Lee
Adesis, Inc., New Castle, DE 19720, Limerick BioPharma, Inc.
South San Francisco
CA, 94080
USA


Marcus Vinícius Nora de Souza
Instituto de Tecnologia em Fármacos-Far-Manguinhos
Rua Sizenando Nabuco 100, Manguinhos
Rio de Janeiro-RJ, 21041-250
Brazil


Marcelle de Lima Ferreira
Instituto de Tecnologia em Fármacos-Far-Manguinhos
Rua Sizenando Nabuco, 100, Manguinhos
Rio de Janeiro-RJ, 21041-250
Brazil


Raoni Schroeder B. Gonçalves
Instituto de Tecnologia em Fármacos-Far-Manguinhos
Rua Sizenando Nabuco, 100, Manguinhos
Rio de Janeiro-RJ, 221041-250
Brazil


Raúl N. Ondarza
Department of Biochemistry
Faculty of Medicine, National Autonomous University of Mexico (UNAM)
University City
Cuernavaca, Morelos
Mexico
CA, 04510
USA


Tsuyoshi Kasama
Division of Rheumatology, Department of Medicine
Showa University School of Medicine
1-5-8 Hatanodai, Shinagawa-ku
Tokyo, 142-8666
Japan


Ryo Takahashi
Division of Rheumatology, Department of Medicine
Showa University School of Medicine
1-5-8 Hatanodai, Shinagawa-ku
Tokyo, 142-8666
Japan


Michihito Sato
Division of Rheumatology, Department of Medicine
Showa University School of Medicine
1-5-8 Hatanodai, Shinagawa-ku
Tokyo, 142-8666
Japan


Kuninobu Wakabayashi
Division of Rheumatology, Department of Medicine
Showa University School of Medicine
1-5-8 Hatanodai, Shinagawa-ku
Tokyo, 142-8666
Japan


Li Li
Department of Laboratory Medicine
First Hospital of Shanghai
Shanghai
China


Shuhong Wu
Department of Thoracic and Cardiovascular Surgery
The University of Texas M. D. Anderson Cancer Center, Houston
Texas , 77030
USA


Wei Guo
Department of Thoracic and Cardiovascular Surgery
The University of Texas M. D. Anderson Cancer Center Houston
Texas, 77030
USA


Bingliang Fang
Department of Thoracic and Cardiovascular Surgery
The University of Texas M. D. Anderson Cancer Center, Houston
Texas, 77030
USA


Virginia Bosó-Ribelles
Pharmacy Department
Hospital La Fe
Valencia
Spain


Eva Romá-Sánchez
Pharmacy Department
Hospital La Fe
Valencia
Spain


Jorge Carmena
Infectious Diseases Department
Hospital Dr. Peset
Valencia
Spain


Cristina Cáceres
Infectious Diseases Department
Hospital Dr. Peset
Valencia
Spain


Daniel Bautista
Preventive Medicine Department
Hospital Dr. Peset
Valencia
Spain


Sukhbir K. Shahid
Consultant Pediatrician and Neonatologist
Mumbai, 400 077
India


Monika I. Konaklieva
Department of Chemistry
American University
4400 Massachusetts Avenue, NW
Washington
DC, 20016-8014
USA


Balbina J. Plotkin
Department of Microbiology and Immunology
CCOM, Midwestern University
555 31 St.
Downers Grove
IL, 60515
USA


Tze Shien Lo
Section of Infectious Diseases
Veterans Affairs Medical Center
Fargo
ND
USA


Justin M. Welch
Pharmacy Department
Veterans Affairs Medical Center
Fargo
ND
USA


Augusto M. Alonto
Section of Infectious Diseases
MeritCare Medical Center
Fargo
ND
USA


Eileen Anne R. Vicaldo-Alonto
Department of Internal Medicine
University of North Dakota School of Medicine & Health Sciences
Fargo
ND
USA


Junko Koyama
Faculty of Pharmaceutical Sciences, Kobe Pharmaceutical University
Higashinada-ku
Kobe, 658-8558
Japan


Vilma G. Duschak
Instituto Nacional de Parasitología “Dr. Mario Fatala Chabén”, ANLIS-Malbrán
Ministerio de Salud. Av. Paseo Colon 568 (1063)
Buenos Aires
Argentina


Alicia S. Couto
CIHIDECAR (CONICET) Departamento de Química Orgánica
Facultad de Ciencias Exactas Naturales
Universidad de Buenos Aires
Buenos Aires
CP, 1428
Argentina


Edward G. Saravolac
Formulation Technology Consulting
3 Essex St., Footscray
Victoria, 3011
Australia


Jonathan P. Wong
Defence R&D Canada - Suffield, Biotechnology Section
Box 4000 Main Station, Medicine Hat
Alberta, T1A 8K6
Canada




Advertisement


Webmaster Contact: urooj@benthamscience.org Copyright © 2014 Bentham Science