Frontiers in Anti-Cancer Drug Discovery

Volume 1

by

Atta-ur-Rahman, Choudhary Iqbal

DOI: 10.2174/97816080516181100101
eISBN: 978-1-60805-161-8, 2015
ISBN: 978-1-60805-626-2
ISSN: 1879-6656 (Print)

  
  


Indexed in: Chemical Abstracts, Scopus, EMBASE

“Frontiers in Anti-Cancer Drug Discovery” is an eBook series devoted to publishing the latest and the most important advances in Anti-...[view complete introduction]
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Table of Contents

Preface

- Pp. i-ii (2)

Atta-ur-Rahman and M. Iqbal Choudhary

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Foreword

- Pp. iii

John K. Buolamwini

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Contributors

- Pp. iv-ix (6)

Atta-ur-Rahman and M. Iqbal Choudhary

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Targeting Ribonucleotide Reductase for Cancer Chemotherapy

- Pp. 1-30 (30)

Nuno M.F.S.A. Cerqueira, Pedro A. Fernandes and Maria J. Ramos

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Thymidine Phosphorylase/Platelet-Derived Endothelial Cell Growth Factor as a Target for Capecitabine: From Biology to the Bedsid

- Pp. 31-54 (24)

Girolamo Ranieri, Aldo Maria Roccaro, Angelo Vacca and Domenico Ribatti

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Inhibitors of the Plasminogen Activation System - Promising New Agents for Suppressing Breast Cancer Metastasis

- Pp. 55-78 (24)

Joel D.A. Tyndall, Michael J. Kelso and Marie Ranson

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Histone Deacetylase Inhibitors in Cancer Therapy

- Pp. 79-115 (37)

Alfredo Budillon, Francesca Bruzzese and Elena Di Gennaro

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Second Generation Abl Tyrosine Kinase Inhibitors and Novel Compounds to Eliminate the Bcr-Abl/T315I Clone (Second Edition)

- Pp. 116-131 (16)

Shinya Kimura

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Aurora Kinase Family: A New Target for Anticancer Drug

- Pp. 132-148 (17)

Teresa Macarulla, M. Elena Elez, Francisco Javier Ramos and Josep Tabernero

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Molecularly Targeted Therapy in Breast Cancer: The Tyrosine Kinase Inhibitors

- Pp. 149-157 (9)

Zeina A. Nahleh

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New Perspectives in the Treatment of Melanoma: Anti-Angiogenic and Anti-Lymphangiogenic Strategies

- Pp. 158-167 (10)

Caterina A.M. La Porta

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Therapeutic Potential of Endogenous Angiogenesis Inhibitors for Cancer Therapy: Historical Perspective and Future Direction

- Pp. 168-193 (26)

Mohanraj Dhanabal and Natarajan Sethuraman

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Calcium Signals in Endothelium and their Role in the Control of Angiogenesis

- Pp. 194-218 (25)

Luca Munaron

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Novel Purine Nucleoside Analogues for Hematological Malignancies

- Pp. 219-240 (22)

Anna Korycka, Ewa Lech-Maranda and Tadeusz Robak

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The Place of Somatostatin Analogs in the Diagnosis and Treatment of the Neuoroendocrine Glands Tumors

- Pp. 241-272 (32)

Gabriela Melen-Mucha, Hanna Lawnicka, Dorota Kierszniewska-Stepien, Jan Komorowski and Henryk Stepien

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Bortezomib in the Treatment of Cancer

- Pp. 273-283 (11)

Aldo M. Roccaro, Angelo Vacca and Domenico Ribatti

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Cetuximab: Its Use in Combination with Radiation Therapy and Chemotherapy in the Multimodality Treatment of Head and Neck Cancer

- Pp. 284-297 (14)

Timothy D. Wagner and Gary Y. Yang

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Platinum-Based Anticancer Agents

- Pp. 298-339 (42)

Irena Kostova

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c-Myc and Downstream Targets in the Pathogenesis and Treatment of Cancer

- Pp. 340-379 (40)

Sam Robson, Inga Pukonen, Sylvie Abouna, Stella Pelengaris and Michael Khan

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Small Molecule Vascular Disrupting Agents: Potential New Drugs for Cancer Treatment, a 2009 Update

- Pp. 380-427 (48)

Sui Xiong Cai

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Developments in Targeted Therapy of Advanced Gastrointestinal Stromal Tumors

- Pp. 428-448 (21)

Piotr Rutkowski, Malgorzata Symonides, Marcin Zdzienicki and Janusz A. Siedlecki

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Therapeutic Transfer of DNA Encoding Adenoviral E1A†

- Pp. 449-464 (16)

Helmut Deissler and Bertram Opalka

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Compositions for Treatment of Cancer and Inflammation

- Pp. 465-480 (16)

Shahar Lev-Ari, Dov Lichtenberg and Nadir Arber

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The Androgen Receptor as Putative Therapeutic Target in Hormone-Refractory Prostate Cancer

- Pp. 481-496 (16)

Yukio Kageyama, Nobuhiko Hyochi, Kazunori Kihara and Hiroshi Sugiyama

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Older and New Formulations of Cladribine: Pharmacology and Clinical Efficacy in Hematological Malignancies

- Pp. 497-524 (28)

Tadeusz Robak, Anna Korycka and Ewa Robak

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Developments of New Compounds and New Strategies in the Field of Cytotoxic Nucleoside Analogues

- Pp. 525-540 (16)

Lars P. Jordheim and Charles Dumontet

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PET in Anti-Cancer Drug Development and Therapy

- Pp. 541-551 (11)

Rakesh Kumar, Dhanpathi Halanaik and Saurabh Dahiya

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The Anti-Cancer Charm of Flavonoids: A Cup-of-Tea Will Do You Good!

- Pp. 552-587 (36)

Amr Amin and Michael Buratovich

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Prevention and Treatment of Regimen-Related Mucosal Toxicity

- Pp. 588-600 (13)

Joanne M. Bowen

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Recent Patents on Bacterial Proteins as Potential Anticancer Agents

- Pp. 601-622 (22)

Arsenio M.Fialho and Ananda M.Chakrabarty

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Recent Patents on Therapeutic Agents for Cancer

- Pp. 623-740 (118)

Xun Li, Yalin Li and Wenfang Xu

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Review of Selected Patents for Cancer Therapy Targeting: Tumor Angiogenesis

- Pp. 741-757 (17)

Mark N. Kirstein and Arkadiusz Z. Dudek

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Targeting Vesicle Trafficking in Cancer Therapeutics

- Pp. 758-776 (19)

Paul K. Wright

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Author Index to Volume 1

- Pp. 778-779 (2)

Bentham Science Publishers

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Foreword

This first Volume of “Frontiers in Anti-Cancer Drug Discovery” published under the Editorship of Prof. Atta-ur-Rahman and Prof. Dr. M. Iqbal Choudhary contains very useful reviews on the latest aspects of anti-cancer drug discovery and development. These articles have been contributed by an impressive group of authors, the majority of whom are well known for their own contributions. Most interestingly, these thirty reviews reflect the rapid changes in approaches towards drug discovery and development, based on the growing understanding of etiology of various cancers at the molecular level. Many of these review articles focus on inhibition of enzymes which play key roles in the on-set of cancer and its progression. Novel classes of compounds and emerging approaches, such as antiangiogenesis, are also the topic of some reviews. Each chapter is well written, up-to-date, adequately illustrated, extensively referenced, and nicely edited. Overall cancer is a complex disease, and this volume reflects the complexity involved in its treatment, as well as the need for a further understanding at the molecular and cellular levels, and designing treatments that target key mechanistic steps.

The authors and editors deserve appreciation for compiling such a scholarly treatise, which should be of benefit both to academic researchers and industrial R & D personnel.

John K. Buolamwini, Ph.D.
Professor
Department of Pharmaceutical Sciences
College of Pharmacy
University of Tennessee Health Science Center
847 Monroe Avenue, Suite 327
Memphis, TN 38163, USA
Tel: 901 448-7533
Fax: 901 448-6828
E-mail: jbuolamwini@uthsc.edu


Preface

Cancer has been a major challenge for health researchers, health care providers, and managers. The increasing incidence of cancer, both in the developed and the developing world, is attributed to longer life spans, life style changes, and environmental factors. Many of the blockbuster anti-cancer drugs of the past are slowly becoming ineffective or undesirable due to acquired resistance of cancer cells, and associated chronic toxicity. This situation demands vigorous efforts in the field of drug development for treatment and prevention. Although mortality due to cancer remains very high, spectacular advances have been made in the discovery of new anti-cancer drugs in recent years. This has been largely due to an enhanced understanding of this group of diseases at a molecular level in the post-genomic period. Not only have new approaches towards the cancer treatment been debated and agreed upon, but new targets and novel classes of anti-cancer compounds have also been discovered.

Volume 1 of this book series entitled "Frontiers in Anti-Cancer Drug Discovery", is a compilation of thirty well written reviews contributed by leading researchers in this field from all across the world. The chapters contain in this volume are the updated version of articles published in Recent Patents on Anti-Cancer Drug Discovery. These reviews can be broadly classified into four categories:

  1. a. Inhibitors of key enzymes in cancer progression,
  2. b. Inhibitors of angiogenesis and other vascular growth factors,
  3. c. Novel classes of natural and synthetic anti-cancer compounds, and
  4. d. Reviews of recent patents on various aspects of cancer treatment.

This volume reflects the complexities involved in tackling this disease and current efforts to control it. It is hoped that this volume and subsequent volumes of this series of books will benefit the scientific community, both in academia and in industry, by fulfilling their needs of comprehensive reviews on recent developments covering different important aspects of cancer drug discovery and development.

We wish to extend our warmest thanks to the staff members of Bentham Science Publishers, including Mr. Mahmood Alam (Managing Director), Ms. Samina Khan (Senior Manager), Ms. Taqdees Malik (Assistant Manager) and Ms. Sadaf Idrees Khan (Composer). They all have made key contributions to the publication of this volume.

Prof. Dr. Atta-ur-Rahman, FRS
Prof. Dr. M. Iqbal Choudhary
Editors

List of Contributors

Editor(s):
Prof. Dr. Atta-ur-Rahman FRS
University of Karachi
Pakistan



Prof. Dr. Choudhary Iqbal
University of Karachi
Pakistan





Contributor(s):
Nuno M.F.S.A. Cerqueira
REQUIMTE / Faculdade de Ciências do Porto
Rua Campo Alegre, 687
Porto, 4169-007
Portugal



Pedro A. Fernandes
REQUIMTE / Faculdade de Ciências do Porto
Rua Campo Alegre, 687
Porto, 4169-007
Portugal



Maria J. Ramos
REQUIMTE / Faculdade de Ciências do Porto
Rua Campo Alegre, 687
Porto, 4169-007
Portugal



Girolamo Ranieri
National Cancer Institute
Interventional Radiology Unit
Bari
Italy



Aldo Maria Roccaro
University of Bari Medical School
Bari
Italy



Angelo Vacca
Department of Biomedical Sciences and Human Oncology
University of Bari Medical School
Bari
Italy



Domenico Ribatti
Department of Human Anatomy and Histology
University of Bari Medical School
Bari
Italy



Joel D. A. Tyndall
National School of Pharmacy, University of Otago
Dunedin
New Zealand



Michael J. Kelso
School of Chemistry, University of Wollongong
NSW, 2522
Australia



Marie Ranson
School of Biological Sciences, University of Wollongong
NSW, 2522
Australia



Alfredo Budillon
Experimental Pharmacology Unit, Department of Research
National Cancer Institute "Fondazione G. Pascale"
Naples
Italy



Francesca Bruzzese
Experimental Pharmacology Unit, Department of Research
National Cancer Institute "Fondazione G. Pascale"
Naples
Italy



Elena Di Gennaro
Experimental Pharmacology Unit, Department of Research
National Cancer Institute "Fondazione G. Pascale"
Naples
Italy



Shinya Kimura
Division of Hematology, Respiratory Medicine and Oncology
Department of Internal Medicine, Faculty of Medicine
Saga University
Saga
Japan



Teresa Macarulla
Medical Oncology Department
Vall d'Hebron University Hospital
Spain



M. Elena Elez
Medical Oncology Department
Vall d'Hebron University Hospital
Spain



Francisco Javier Ramos
Medical Oncology Department
Vall d'Hebron University Hospital
Spain



Josep Tabernero
Medical Oncology Department
Vall d'Hebron University Hospital
Spain



Zeina A. Nahleh
Division of Hematology-Oncology, Karmanos Cancer Institute
Wayne State University, 4100 John R, 4HWCRC
Detroit
MI, 48201
USA



Caterina A.M. La Porta
Department of Biomolecular Science and Biotechnology
University of Milan
Milan , 20133
Italy



Mohanraj Dhanabal
EMD Serono Inc., One Technology Place
Rockland
MA, 02370
USA



Natarajan Sethuraman
GlycoFi, 21 Lafayette Street, Suite 200
Lebanon
NH, 03766-1445
USA



Luca Munaron
Department of Animal and Human Biology and Nanostructured Interfaces and Surfaces Centre of Excellence (NIS)
University of Torino, Via Accademia Albertina 13
Torino, 10123
Italy



Anna Korycka
Department of Hematology
Medical University of Lodz and Copernicus Memorial Hospital
Pabianicka 62
Lodz, 93-513
Poland



Ewa Lech-Marańda
Department of Hematology
Medical University of Lodz and Copernicus Memorial Hospital
Pabianicka 62
Lodz, 93-513
Poland



Tadeusz Robak
Department of Hematology
Medical University of Lodz and Copernicus Memorial Hospital
Pabianicka 62
Lodz, 93-513
Poland



Gabriela Melen-Mucha
Department of Immunoendocrinology
Medical University of Lodz
Kopcinskiego 22 Street
Lodz
Poland



Hanna Lawnicka
Department of Immunoendocrinology
Medical University of Lodz
Kopcinskiego 22 Street
Lodz
Poland



Dorota Kierszniewska-Stepien
Department of Pneumology and Allergology
Medical University of Lodz
Kopcinskiego 22 Street
Lodz
Poland



Jan Komorowski
Department of Clinical Endocrinology
Chair of Endocrinology, Medical University of Lodz
91-425 Lodz, Dr Sterling 3 Street
Lodz
Poland



Henryk Stepien
Department of Immunoendocrinology
Medical University of Lodz
Kopcinskiego 22 Street
Lodz
Poland



Aldo M. Roccaro
Department of Internal Medicine and Clinical Oncology
University of Bari Medical School
Bari
Italy



Angelo Vacca
Department of Internal Medicine and Clinical Oncology
University of Bari Medical School
Bari
Italy



Domenico Ribatti
Department of Human Anatomy and Histology
University of Bari Medical School
Bari
Italy



Timothy D. Wagner
Department of Radiology
Radiation Oncology Service, Brooke Army Medical Center
Fort Sam Houston
Texas
USA



Gary Y. Yang
Department of Radiation Medicine
Roswell Park Cancer Center, Buffalo
New York
USA



Irena Kostova
Department of Chemistry, Faculty of Pharmacy
Medical University, 2 Dunav St.
Sofia, 1000
Bulgaria



Sam Robson
Biological Sciences
Biomedical Research Institute
University of Warwick, CV4 7AL
Coventry
UK



Inga Pukonen
Biological Sciences
Biomedical Research Institute
University of Warwick, CV4 7AL
Coventry
UK



Sylvie Abouna
Biological Sciences
Biomedical Research Institute
University of Warwick, CV4 7AL
Coventry
UK



Stella Pelengaris
Biological Sciences
Biomedical Research Institute
University of Warwick, CV4 7AL
Coventry
UK



Michael Khan
Biological Sciences
Biomedical Research Institute
University of Warwick, CV4 7AL
Coventry
UK



Sui Xiong Cai
IMPACT Therapeutics, Inc.
10 Xinghuo Road, Floor 9, High
New Technology Zone, Nanjing
Jiangsu, 210061
China



Piotr Rutkowski
Department of Soft Tissue/Bone Sarcoma and Melanoma
M. Sklodowska-Curie Memorial Cancer Center and Institute of Oncology
Warsaw
Poland



Małgorzata Symonides
Department of Anesthesiology
M. Sklodowska-Curie Memorial Cancer Center and Institute of Oncology
Warsaw
Poland



Marcin Zdzienicki
Department of Soft Tissue/Bone Sarcoma and Melanoma
M. Sklodowska-Curie Memorial Cancer Center and Institute of Oncology
Warsaw
Poland



Janusz A. Siedlecki
Department of Anesthesiology
M. Sklodowska-Curie Memorial Cancer Center and Institute of Oncology
Warsaw
Poland



Helmut Deissler
Department of Obstetrics and Gynecology
University of Ulm Medical School
Ulm
Germany



Bertram Opalka
Department of Obstetrics and Gynecology
University of Ulm Medical School
Ulm
Germany



Shahar Lev-Ari
Department of Cancer Prevention
Tel Aviv Medical Center; The Sackler Faculty of Medicine
Tel Aviv University
Israel



Dov Lichtenberg
The Sackler Faculty of Medicine
Tel Aviv University
Israel



Nadir Arber
Department of Cancer Prevention
Tel Aviv Medical Center;
The Sackler Faculty of Medicine
Tel Aviv University
Israel



Yukio Kageyama
Department of Urology
Saitama Cancer Center
Saitama, 362-0806
Japan

Department of Urology
Graduate School Tokyo Medical and Dental University
Tokyo, 113-8519
Japan



Nobuhiko Hyochi
Department of Urology
Graduate School Tokyo Medical and Dental University
Tokyo, 113-8519
Japan



Kazunori Kihara
Department of Urology
Graduate School Tokyo Medical and Dental University
Tokyo, 113-8519
Japan



Hiroshi Sugiyama
Department of Chemistry
Graduate School of Science, Kyoto University
Kyoto, 606-8502
Japan



Tadeusz Robak
Department of Hematology
Medical University of Lodz and Copernicus Memorial Hospital
93-513 Lodz, Pabianicka 62, 606-8502
Poland



Anna Korycka
Department of Hematology
Medical University of Lodz and Copernicus Memorial Hospital
93-513 Lodz, Pabianicka 62, 606-8502
Poland



Ewa Robak
Department of Dermatology
Medical Uniwersity of Lodz
94-017 Lodz, Krzemieniecka 5
Poland



Lars P. Jordheim
Laboratoire de Cytologie Analytique – INSERM U590
Université Claude Bernard Lyon 1, Lyon
France



Charles Dumontet
Laboratoire de Cytologie Analytique – INSERM U590
Université Claude Bernard Lyon 1, Lyon
France



Rakesh Kumar
Department of Nuclear Medicine
All India Institute of Medical Sciences
Ansari nagar
India



Dhanpathi Halanaik
Department of Nuclear Medicine
All India Institute of Medical Sciences
Ansari nagar
India



Saurabh Dahiya
Department of Nuclear Medicine
All India Institute of Medical Sciences
Ansari nagar
India



Amr Amin
Biology Department
College of Science, UAE University
UAE



Michael Buratovich
Department of Biochemistry
Spring Arbor University
MI, 49283
USA



Joanne M. Bowen
Department of Medical Oncology
Royal Adelaide Hospital, and School of Medicine
University of Adelaide, South Australia
Adelaide, 5000
Australia



Arsenio M. Fialho
Instituto for Biotechnology and BioEngineering (IBB)
Center for Biological and Chemical Engineering
Institute Superior Tecnico
Lisbon, 1049-001
Portugal



Ananda M. Chakrabarty
Department of Microbiology and Immunology
University of Illinois College of Medicine
835 South Wolcott Avenue
Chicago
IL, 60612
USA



Xun Li
Department of Medicinal Chemistry
School of Pharmaceutical Sciences, Shandong University, Ji’nan
Shandong Province, 250012
P.R. China



Yalin Li
State Intellectual Property Office of China
Beijing, 100088
P.R. China



Wenfang Xu
Department of Medicinal Chemistry
School of Pharmaceutical Sciences, Shandong University, Ji’nan
Shandong Province, 250012
P.R. China



Mark N. Kirstein
Department of Experimental and Clinical Pharmacology
College of Pharmacy and Masonic Comprehensive Cancer Center
University of Minnesota
USA



Arkadiusz Z. Dudek
Department of Medicine and Masonic Comprehensive Cancer Center
University of Minnesota
USA



Paul K. Wright
Department of Histopathology
Clinical Sciences Building
1 Floor, Manchester Royal Infirmary, Oxford Road
Manchester, M13 9WL
UK





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