Physiopathogenesis of Hematological Cancer


by

Estela M. Novak, Eduardo M. Rego

DOI: 10.2174/97816080525921120101
eISBN: 978-1-60805-259-2, 2012
ISBN: 978-1-60805-588-3

  
  


Indexed in: Scopus

The number of new discoveries related to diagnostics and therapeutics of hematological cancer is significant. These have resulted in c...[view complete introduction]
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Table of Contents

Foreword , Pp. i

Roberto Passetto Falcao
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Preface , Pp. ii

Estela Maria Novak and Eduardo Magalhaes Rego
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List of Contributors , Pp. iii-iv (2)

Estela Maria Novak and Eduardo Magalhaes Rego
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Acknowledgements , Pp. v

Estela Maria Novak and Eduardo Magalhaes Rego
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Normal and Leukemic Hematopoietic Cells Niche , Pp. 3-9 (7)

Eduardo Magalhaes Rego and Mirela de Barros Tamarozzi
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Cancer Stem Cells , Pp. 10-13 (4)

Sara T. O. Saad
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Programmed Cell Death: Apoptosis, Autophagy, Necrosis and Oxidative Stress in Hematological Malignacies , Pp. 14-33 (20)

Enny Fernandes Silva
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Proteasome Inhibition in Hematological Malignancies , Pp. 34-49 (16)

Guilherme Augusto Silva dos Santos
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Epigenetics and DNA Methylation Modifications , Pp. 50-59 (10)

Fabiola Traina
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microRNAs and Non-Coding RNAs in Hematological Malignancies , Pp. 60-77 (18)

Hamilton Luiz Gimenes Teixeira and Eduardo Magalhaes Rego
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Transcription Factors in Hematological Malignancies , Pp. 78-102 (25)

Estela Maria Novak and Durvanei Augusto Maria
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Protein Prenylation and Hematological Malignancies , Pp. 103-121 (19)

Chin Jia Lin and Mirna Alameddine
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Hematological Neoplasia and Angiogenesis: A Review , Pp. 122-150 (29)

Estela Maria Novak
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Physiopathogenesis of Lymphoma , Pp. 151-167 (17)

Edgar Gil Rizzatti
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Molecular Basis of Acute Lymphoblastic Leukemia , Pp. 168-182 (15)

Carlos Alberto Scrideli and Luiz Gonzaga Tone
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Physiopathogenesis of Multiple Myeloma , Pp. 183-192 (10)

Luciana Correa Oliveira de Oliveira and Eduardo Magalhaes Rego
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Chronic Myeloproliferative Diseases , Pp. 193-200 (8)

Katia B. Barbosa Pagnano
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Acute Myeloproliferative Disease , Pp. 201-217 (17)

Eduardo Magalhaes Rego and Mariana Tereza de Lira Benicio
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Molecular Targeted Therapies for Hematologic Malignancies , Pp. 218-227 (10)

Alexandre Nonino
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Glossary Terms , Pp. 228-238 (11)

Estela Maria Novak and Eduardo Magalhaes Rego
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Index , Pp. 239-243 (5)

Estela Maria Novak and Eduardo Magalhaes Rego
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Foreword

The annual incidence of hematological malignancies in Europe approaches 20 per 100000, making them the most common type of cancer in this continent and the world. The rapidly increased amount of new information generated in this field justifies their transference, in an organized form, to professionals who take care of these patients. This book has this purpose and approaches the subject of the hematological malignancies from a basic scientific standpoint and will be of great value to both clinicians and scientists working in this field. The first Section deals with the molecular and cellular biology of hematological tumors describing and discussing normal and leukemic hematopoeisis, cancer stem cells, apoptosis, epigenetics, microRNA, transcription factors, protein prenylation, and angiogenesis. The second Section discusses the molecular basis of lymphoid neoplasias with emphasis on lymphomas, multiple myeloma, and acute lymphoblastic leukemia. Section III on the the molecular pathogenesis of acute and chronic mieloproliferative disorders. Finally, Section IV presents the molecular basis of cancer therapy and future perspectives. All the contributors are experts in their fields and work in Brazil. The majority are affiliated to the University of São Paulo (USP) and University of Campinas (Unicamp).

Roberto Passetto Falcão
Professor in Hematology, Medical School of Ribeirão Preto
National Institute of Science and Technology in Stem Cell and Cell Therapy
University of São Paulo, Ribeirão Preto, SP
Brazil


Preface

The mature and functional cells in blood have limited life spans and must be replenished in precise numbers. The physiological control of hematopoiesis depends on the cell proliferation and differentiation of stem cells and hematopoietic progenitors, which are influenced by intracellular and microenvironmental signals. Hematological malignancies are a heterogenous group of diseases in which different genetic and epigenetic aberrations lead to deregulation of cell growth, differentiation and protein biosynthesis. Basic knowledge about the molecular mechanisms of malignant transformation of blood cells is today a sine quoi non requirement for the adequate diagnosis, prognosis stratification and therapy. Indeed, recent advances in our understanding of the molecular basis of malignant diseases such as chronic myeloid leukemia and acute promyelocytic leukemia led to novel therapeutic strategies targeting relevant pathways that regulate cell proliferation or differentiation. Several of these new target therapies have now demonstrated significant benefit in disease-free and overall survival of these patients.

The study of the physiopathology of hematological malignancies requires fundaments of molecular biology, biochemistry, physiology, embryology, pathology, among others. Moreover, it is a rapidly ever evolving field. Therefore, it is difficult for undergraduate students as well as for clinical hematologists to have an updated overview of the main mechanisms involved in hematologic cancers. The aim of the present book is to introduce the most important molecular and cellular concepts which we believe have direct impact in daily clinical practice.

Estela Maria Novak & Eduardo Magalhães Rego

List of Contributors

Editor(s):
Estela M. Novak
Molecular Biology Division
Pró-Sangue Hemocentro of São Paulo Foundation
Brazil


Eduardo M. Rego
Medical School of Ribeirão Preto
University of São Paulo
Brazil




Contributor(s):
Alexandre Nonino
Hematology Consultant
Hematology Department - Hospital de Base do Distrito Federal
Brasília
Brazil


Carlos Alberto Scridelli
Assistant Professor, Pediatrics Department
Faculdade de Medicina de Ribeirão Preto
Universidade de São Paulo
Ribeirão Preto
São Paulo
Brazil


Chin Jia Lin
Assistant Professor, Department of Pathology
University of São Paulo
School of Medicine
São Paulo
Brazil


Durvanei Augusto Maria
Investigator, Laboratory of Biochemistry and Biophysics
Butantan Institute
São Paulo
Brazil


Edgar Gil Rizzatti

Medical Consultant in Hematology and Coordinator in Research and Development at Fleury Group
São Paulo
Brazil


Eduardo Magalhães Rego
Professor of Hematology/ Oncology, Department of Internal Medicine
National Institute of Science and Technology on Cell Based Therapy
Medical School of Ribeirão Preto
University of São Paulo
Ribeirão Preto
Brazil


Enny Fernandes Silva
Professor, Department of Biochemistry and Pathology
Universidade Paulista
São Paulo
Brazil


Estela Maria Novak
Investigator, Molecular Biology Division
Pró-Sangue Hemocentro of São Paulo Foundation
São Paulo
Brazil


Fabiola Traina
Researcher Associate and Chief of the Cytogenetics Laboratory of Hematology and Hemotherapy Center
University of Campinas
São Paulo
Brazil


Guilherme Augusto dos Santos
Hematology Consultant, Hospital Clínicas de Ribeirão Preto
Department of Internal Medicine
National Institute of Science and Technology on Cell Based Therapy
Medical School of Ribeirão Preto
University of São Paulo
Ribeirão Preto
Brazil


Hamilton Luiz Gimenes Teixeira
Postdoctoral fellow, Department of Internal Medicine
National Institute of Science and Technology on Cell Based Therapy
Medical School of Ribeirão Preto
University of São Paulo
Ribeirão Preto
São Paulo
Brazil


Katia Borgia Barbosa Pagnano
Research Associate, Hematology-Hemotherapy Division
Internal Medicine Department
University of Campinas
Campinas
São Paulo
Brazil


Luciana Correa Oliveira de Oliveira
Hematology Consultant, Hospital de Clínicas de Ribeirão Preto
Department of Internal
Medicine National Institute of Science and Technology on Cell Based Therapy
Medical School of Ribeirão Preto
University of São Paulo
Ribeirão Preto
São Paulo
Brazil


Luiz Gonzaga Tone
Full professor, Pediatrics Department
Medical School of Ribeirão Preto
University of São Paulo
Ribeirão Preto
São Paulo
Brazil


Mariana Tereza de Lira Benício
Postdoctoral fellow, Department of Internal Medicine
National Institute of Science and Technology on Cell Based Therapy
Medical School of Ribeirão Preto
University of São Paulo
Ribeirão Preto
São Paulo
Brazil


Mirna Alameddine
Investigator, Laboratory of Molecular Pathology
Department of Pathology
University of São Paulo
School of Medicine
São Paulo
Brazil


Mirela de Barros Tamarozzi
Postdoctoral fellow, Department of Internal Medicine
National Institute of Science and Technology on Cell Based Therapy
Medical School of Ribeirão Preto
University of São Paulo
Ribeirão Preto
São Paulo
Brazil


Sara T. O. Saad
Full Professor, Hematology-Hemotherapy Division
Internal Medicine Department
University of Campinas
Campinas
São Paulo
Brazil




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