Beta-glucan, Structure, Chemistry and Specific Application

Book Series: Biology and Chemistry of Beta Glucan

Volume 2

by

Vaclav Vetvicka, Miroslav Novak

DOI: 10.2174/97816080526081130201
eISBN: 978-1-60805-260-8, 2013
ISBN: 978-1-60805-301-8
ISSN: 2211-0526 (Print)



Indexed in: Ulrich's Periodicals Directory.

Despite of the efforts of pharmaceutical researchers to find new medicaments, nature offers many substances with healing properties—be...[view complete introduction]

Modulation of Photodynamic Therapy by β-Glucan

- Pp. 112-130 (19)

Dalia Akramienė

Abstract

Photodynamic therapy (PDT) combines a drug or photosensitizer with a specific type of light to eradicate cancer cells. The cellular damage induced by PDT leads to activation of the DNA damage repair, which is an important factor for modulating tumor sensitivity to this treatment. β-Glucans bind complement receptor 3 on the effector cells, thereby activating them to kill tumor cells during PDT. Here, the hypothesis that adjuvant therapy with β-glucans would increase the efficacy of PDT resulting in pronounced necrosis of PDT-treated tumors and suppression of the DNA damage repair system is discussed.

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