Theory in the Pathophysiology of Carcinogenesis


by

Lawrence M. Agius

DOI: 10.2174/97816080526601110101
eISBN: 978-1-60805-266-0, 2011
ISBN: 978-1-60805-640-8



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Indexed in: Scopus

This e-book explains the essential role of angiogenesis in the progression and spread of the neoplasm, including the mechanics of init...[view complete introduction]

Table of Contents

Introduction

- Pp. i-ii (2)

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Preface

- Pp. iii

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Regionality of Anti-Apoptosis Predetermines Pro-Neoplastic Biology of Cell Proliferation as Induced Metastatic Spread

- Pp. 3-8 (6)

Lawrence M. Agius

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Contrasting Profiles of High Grade Gliomas as Malignant Transformation of the Individual Neoplastic Astrocyte

- Pp. 9-15 (7)

Lawrenc M. Agius

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Increments in Cellular Proliferation as Defining Index in Dysplasia and Malignant Transformation in Ulcerative Colitis--Amplifying Attributes of Neogenesis

- Pp. 16-21 (6)

Lawrence M. Agius

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Hypothetical Simple Transfer Mechanics as Malignant Transformation and as Infiltrative and Metastatic Neoplastic Potential

- Pp. 22-27 (6)

Lawrence M. Agius

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Integral Composite of Malignant Transformation and Metastatic Potentiality in Osteosarcoma

- Pp. 28-34 (7)

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Aberrant Cell Cycling Potentiates Genetic Instability in Astrocytoma Transformation

- Pp. 35-43 (9)

Lawrence M. Agius

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Peritoneal Implantation as Integral Non-Sequential Events in Susceptibility to Ovarian Carcinogenesis

- Pp. 44-48 (5)

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Transition Dynamics of In Situ Carcinogenesis

- Pp. 49-51 (3)

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Basic and Implied Formulation of Tumor Angiogenesis as Template Constructs

- Pp. 52-62 (11)

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Dimensions of Malignant Lymphomatous Transformation in Immunodeficiency

- Pp. 63-64 (2)

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Dimensionality of the Carcinogenesis Patterns in De-Evolution

- Pp. 65-72 (8)

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Integral Tissue Participation in Carcinogenesis

- Pp. 73-74 (2)

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Source of Permutation in Genotoxicity in Malignant Transformation

- Pp. 75-78 (4)

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Index

- Pp. 79-80 (2)

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Preface

Dynamics of transfer mechanics appear to selectively target replicating cells in a manner that directly contributes to the genesis of a lesion of self-amplifying proportions. In this sense, the modulation of the microenvironment is an acquired transformation that leads directly to promote genotoxic influence persistently. In a manner specifically characterizing the cells influencing injury to groups of target cells there would develop a range of integrative pathways directly promoting a constitutive interplay for further interactivity at the cell-stromal interphase.

Significant participation of influence by transfer mechanics is a promotional factor in constitutive replication of cells that significantly compromises the integrity of such cell-stromal interphase. It is such significant involvement of parenchymal or epithelial cells that implicates directly a series of modulatory phasic responses that are conducive to further change by representative systems of remodeled stroma and angiogenesis.

Realization of injury as carcinogenesis is therefore a multi-staged process in the emergence of autonomously replicating groups of cells that clonally recharacterize the interactive dynamics with stroma. The cytokine-chemokine systems participate in further amplifying the effects of genotoxic injury beyond the replicative activity of such groups of cells.

In a final analysis, pathways of interaction would evolve constituted as end pathways of transforming potentiality of integral tissue regions in terms of foci of reproducibility and spread.

It is such regional constitutive remodeling that constitutes an effective platform for systemic projection of injured cells in the acquisition of stem-cell-like capabilities and as malignant transformation of cells. Systemic dimensionalization of such transformation is central to a carcinogenesis that self-promotes transfer mechanics as integrally clonal cells of neoplastic type.

Lawrence M Agius MD
University of Malta Medical School
Mater Dei Hospital
Malta Europe
E-mail: lawrence.agius@gov.mt

List of Contributors

Author(s):
Lawrence M. Agius
University of Malta Medical School
Mater Dei Hospital
Malta




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