Free Radical Biomedicine: Principles, Clinical Correlations, and Methodologies


by

Y. Robert Li

DOI: 10.2174/97816080532231120101
eISBN: 978-1-60805-322-3, 2012
ISBN: 978-1-60805-530-2



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Indexed in: Scopus

Free radicals and related reactive species, including reactive oxygen and nitrogen species (ROS/RNS) play a critical role in the patho...[view complete introduction]

Table of Contents

About the Book

- Pp. i

Y. Robert Li

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About the Author

- Pp. ii

Y. Robert Li

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Preface

- Pp. iii

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Introduction to Free Radical Biomedicine

- Pp. 3-9 (7)

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Free Radicals and Related Reactive Species

- Pp. 10-39 (30)

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Antioxidants

- Pp. 40-93 (54)

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Free Radicals and Related Reactive Species in Cardiovascular Diseases

- Pp. 94-112 (19)

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Free Radicals and Related Reactive Species in Diabetes Mellitus and Metabolic Syndrome

- Pp. 113-126 (14)

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Free Radicals and Related Reactive Species in Neurological Diseases

- Pp. 127-152 (26)

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Free Radicals and Related Reactive Species in Pulmonary Diseases

- Pp. 153-172 (20)

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Free Radicals and Related Reactive Species in Hepatic and Gastrointestinal Diseases

- Pp. 173-201 (29)

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Free Radicals and Related Reactive Species in Renal Diseases

- Pp. 202-216 (15)

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Free Radicals and Related Reactive Species in Cancer

- Pp. 217-231 (15)

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Free Radicals and Related Reactive Species in Aging

- Pp. 232-241 (10)

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Free Radicals and Related Reactive Species in Other Diseases and Conditions

- Pp. 242-269 (28)

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Detection of Free Radicals and Related Reactive Species

- Pp. 270-294 (25)

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Detection of Damage of Biomolecules by Free Radicals and Related Reactive Species

- Pp. 295-306 (12)

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Detection and Measurement of Cellular and Tissue Antioxidants

- Pp. 307-325 (19)

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Index

- Pp. 326-342 (17)

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Preface

The last two to three decades have witnessed the remarkable advances in our knowledge about free radicals and related reactive species, especially reactive oxygen and nitrogen species (ROS/RNS) in biomedicine. It has been increasingly recognized that ROS/RNS play an important role in the pathophysiology of diverse diseases, including cardiovascular diseases, diabetes and metabolic syndrome, neurological disorders, and cancer among many others. In agreement with this notion, substantial studies have demonstrated the effectiveness of various antioxidant-based modalities in disease intervention. New knowledge in free radical biomedicine will certainly further increase our ability to develop more effective mechanistically-based strategies to combat human diseases that involve a free radical-mediated pathophysiological component.

This book integrates knowledge in free radical biomedicine from essentials to advances, and from basic research to clinical correlations. It also covers basic and advanced methodologies in free radical research. It is hoped that the book will provide the reader a unique approach to understanding the rapidly evolving field of free radical biomedicine.

This book would not have been possible without the assistance of my son Jason Z. Li who drew all the chemical structures for the whole book, and my wife H. Zhu, MD for her critical review of the entire book manuscript. I am grateful to those (over 100 scientists worldwide) who provided me reprints of their publications and/or expertly reviewed part of the book manuscript. I am thankful for the time and effort made by the editorial personnel, especially Ms. Sarah Khan at Bentham Science Publishers, and the constructive suggestions resulting from the outside peer-review of the entire book manuscript sponsored by Bentham Science Publishers.

Y. Robert Li, MD, MPH, PhD
Virginia Tech Corporate
Research Center
Blacksburg
Virginia
USA
yli@vcom.vt.edu

List of Contributors

Author(s):
Y. Robert Li
Virginia Tech Corporate Research Center
Blacksburg
Virginia
USA




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