Nephrology and Clinical Chemistry: The Essential Link


by

Pierre Delanaye

DOI: 10.2174/97816080533391120101
eISBN: 978-1-60805-333-9, 2012
ISBN: 978-1-60805-639-2



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Indexed in: Scopus

Clinical chemistry is a science that requires specific knowledge and teaching. The e-book covers several topics in clinical nephrology...[view complete introduction]

Table of Contents

Foreword

- Pp. i

Rossini C. Botev and Christophe Mariat

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Preface

- Pp. ii

Pierre Delanaye

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List of Contributors

- Pp. iii

Pierre Delanaye

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Good Interpretation of a Biological Result: Generality and Specificity to Nephrology

- Pp. 3-8 (6)

Etienne Cavalier

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Serum Creatinine: An Old and Modern Marker of Renal Function

- Pp. 9-20 (12)

Pierre Delanaye

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An Emerging Marker of Glomerular Filtration Rate: Cystatin C

- Pp. 21-40 (20)

Laurence Pieroni

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Beta-Trace Protein and GFR

- Pp. 41-48 (8)

Christine A. White

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New Biomarkers in Acute Kidney Injury

- Pp. 49-57 (9)

Sachin S. Soni, Sonali S. Saboo, Anuradha Raman, Rajasekara M. Chakravarti, Vikranth Reddy, Rupesh Pophale and Ashish S. Bhansali

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Estimation of Glomerular Filtration with Creatinine-based Equations

- Pp. 58-65 (8)

Christine A. White and Emilio D. Poggio

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Epidemiology of Chronic Kidney Disease: The Role of the Laboratory

- Pp. 66-73 (8)

Eric P. Cohen

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Anemia Management and Iron Monitoring in Patients Treated with Erythropoiesis-stimulating Agents

- Pp. 74-90 (17)

Christophe Bovy

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Measurement of Parathormone in Chronic Kidney Disease: An Easy Task?

- Pp. 91-105 (15)

Jean-Claude Souberbielle

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Biological Parameters for the Diagnosis of Bone Turnover in Dialysis Patient

- Pp. 106-121 (16)

Pablo Urena Torres

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Vascular Calcifications in Chronic Kidney Disease: Can the Biologist be of Some Help?

- Pp. 122-133 (12)

Anne-Sophie Bargnoux, Marion Morena, Anne-Marie Dupuy, Etienne Cavalier, Georges Mourad, Pierre Delanaye, Bernard Canaud and Jean-Paul Cristol

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Fibroblast Growth Factor 23: The Missing Link in Phosphate Homeostasis

- Pp. 134-140 (7)

Dominique Prie

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Markers of Acute and Chronic Rejection in Renal Transplantation

- Pp. 141-149 (9)

Nicolas Degauque and Sophie Brouard

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Index

- Pp. 150-151 (2)

Pierre Delanaye

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Foreword

Beyond the invaluable dosage of serum creatinine, Clinical Chemistry continues to greatly contribute to the majority of decision-making processes encountered in Nephrology. This is evident for the so-called “Chronic Kidney Disease-Mineral and Bone Disorder” for which, both diagnosis and prognosis largely benefit from numerous informative markers provided by the Biochemist. This is even more obvious with the continuous development of new biomarkers in the field of Acute Kidney Injury – the Quest for the kidney BNP – and of Transplantation as well – the Quest for dysfunction prediction –.

The different chapters assembled in this ebook under the direction of Dr Pierre DELANAYE cover the main biological aspects of “modern” Nephrology. Most of them are precious tools already available for the Clinicians.

We have no doubt that the Nephrology community will welcome this ebook and will acknowledge the helpful hand, the biochemist keeps offering us.

Rossini C. Botev, MD, FASN
Department of Nephrology
HPMG
Honolulu, HA
USA

Christophe Mariat, MD, PhD
Department of Nephrology and Renal Transplantation
University Jean Monnet
Saint Etienne
France


Preface

One specific aspect of Clinical Nephrology is the lack of overt clinical symptoms. Indeed, patients with severe chronic kidney disease may be quasi asymptomatic. In this view, results from clinical laboratory are of the highest importance. Clinical chemistry is a true science and art that require specific knowledge and teaching. The matter is that clinicians, next to the patient, and clinical biologists, in their lab, are far from each other. They have yet a lot of things to share and to learn from each other. The goal of this E-book is to make these two health professionals somewhat closer. Several topics in Nephrology will be discussed with a special focus on their “biological” aspects. In the first chapter, Etienne Cavalier will review some data from Clinical Chemistry that clinicians should know. The role of Clinical Chemistry is obviously fundamental in the diagnosis of chronic kidney disease. Five chapters of this E-book will be devoted to the diagnostic of renal failure. We will review in depth the old creatinine marker. New interesting markers will be discussed in the context of chronic kidney disease. Laurence Piéroni and Christine White will review strengths and limitations of cystatine C and beta trace protein, respectively. Sachin Soni will deeply discuss issues regarding the diagnosis of acute kidney disease and the role of new biomarkers in this context. Christine White and Emilio Poggio will compile current knowledge about the glomerular filtration estimation by the creatinine-based equations, while Eric Cohen will critically discuss the use those estimators in the context of chronic kidney disease prevalence. The second part of the E-book will concern the complications of renal diseases. Anemia is a frequent complication and Christophe Bovy will highlight the necessity of adequate monitoring of anemia and iron storage. Renal osteodystrophy (or chronic kidney disease-mineral disease) is also a classical complication in uremic patients. Given the difficulty to implement the histological gold standard (i.e. bone biopsy), biological markers play a fundamental role in following chronic kidney disease patients. Jean-Claude Souberbielle will deeply review the limitations of the parathormone measurement and Pablo Urena-Torres will elegantly discuss the new biomarkers proposed to better apprehend bone turn-over. All nephrologists know that chronic kidney disease patients have the highest risk for cardiovascular disease. This risk might be linked to the active process of vascular calcification. In this topic, several new markers (pro and anti-calcification) can be measured in the blood and are thought to be of interest to predict vascular calcification (and maybe the “vascular” morbidity). Anne- Sophie Bargnoux and Jean-Paul Cristol will present all the biomarkers involved in the vascular calcifications process. Dominique Prié will more particularly focus on our current knowledge on FGF-23 and its specific role in phosphorus homeostasis. The last chapter will be dedicated to renal transplantation. Nicolas Degauque and Sophie Brouard will review the emerging biomarkers for acute and chronic rejection.

I want to deeply thank all the authors who have contributed to this e-Book. They have all worked hard to make this publication a success. I want to acknowledge my wife, Rosalie, for her help and unfailing support in editing this e-Book.

Eventually, I would like to thank Dr. Rossini Botev and Prof. Christophe Mariat for writing the foreword and Bentham Science Publishers for their support.

Pierre Delanaye, MD
University of Liège
Liège
Belgium

List of Contributors

Editor(s):
Pierre Delanaye
University of Liège
Belgium




Contributor(s):
A-S. Bargnoux
Department of Biochemistry
CHRU Montpellier
University of Montpellier 1
Montpellier
France


C. Bovy
Nephrology
University of Liège
Liège
Belgium


S. Brouard
UMR 643, INSERM
University of Nantes
Nantes
France


E. Cavalier
Clinical Chemistry
University of Liège
Liège
Belgium


E.P. Cohen
Department of Medicine
Medical College of Wisconsin
Froedtert Hospital
Milwaukee
USA


J-P. Cristol
Department of Biochemistry
CHRU Montpellier
University of Montpellier 1
Montpellier
France


N. Degauque
UMR 643, INSERM
University of Nantes
Nantes
France


P. Delanaye
Nephrology
University of Liège
Liège
Belgium


L. Piéroni
Service de Biochimie Métabolique
Groupe Hospitalier Pitiè-Salpétrière
AP-HP
Paris
France


E. Poggio
Department of Nephrology and Hypertension
Renal Function Laboratory, CCF
Cleveland
USA


D. Prié
Faculté de Médecine
INSERM U845
Service des Explorations Fonctionnelles
Université Paris Descartes
Hôpital Necker-Enfants Malades
Paris
France


S. Soni
Manik Hospital and Research Centre
Seth Nandlal Dhoot Hospital
Aurangabad
India


J-C. Souberbielle
Laboratoire d’Explorations Fonctionnelles
Hôpital Necker-Enfants Malades
AP-HP
Paris
France


Torres P. Urena
Service de Physiologie et de Néphrologie
Hôpital Necker-Enfants Malades
AP-HP
Paris
France


C. White
Nephrology
Queen’s University
Kingston
ON
Canada




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