Lung Cancer: Clinical and Surgical Specifications


by

Akin E. Balci

DOI: 10.2174/97816080544281130101
eISBN: 978-1-60805-442-8, 2013
ISBN: 978-1-60805-443-5

  
  




Lung cancer diagnosis worldwide has advanced considerably. Progress in diagnostic techniques and therapeutic methods has greatly impro...[view complete introduction]
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Table of Contents

Foreword , Pp. i

Yavuz Selim Ilhan
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Preface , Pp. ii

Akın Eraslan Balcı
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List of Contributors , Pp. iii-vi (4)

Akın Eraslan Balcı
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Epidemiology and Carciongenesis of Lung Cancer Part A: Factors Related with Lung Cancer Epidemiology , Pp. 3-12 (10)

Gamze Kirkil
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Epidemiology and Carciongenesis of Lung Cancer Part B: Lung Cancer Cancerogenesis , Pp. 13-20 (8)

Murat Kara
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Histopathologic Features of the Lung Cancer , Pp. 21-48 (28)

Semen Onder and Ibrahim Hanifi Ozercan
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Genetics of Lung Cancer , Pp. 49-105 (57)

Ebru Önalan Etem
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Symptoms, Clinical Findings and Paraneoplastic Syndromes in Lung Cancer , Pp. 106-118 (13)

Tulin Cağatay and Gulfer Okumus
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Radiological Evaluation of Lung Cancer , Pp. 119-128 (10)

Ahmet Kürşad Poyraz and Abdurrahman Yasin Erkin Oğur
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Current Scintigraphic Imaging of Lung Cancer , Pp. 129-164 (36)

Tansel Ansal Balci
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Lung Cancer Staging , Pp. 165-174 (10)

Serdar Erturan and Günay Aydin
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Pulmonary Nodules Less Than One Centimeter in Size , Pp. 175-182 (8)

Dalokay Kiliç, Alper Findikçioğlu and Ahmet Hatipoğlu
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Invasive Surgical Techniques in the Mediastinal Staging in Non- Small Cell Lung Cancer , Pp. 183-198 (16)

Mehmet Oğuzhan Özyurtkan
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Lung Cancer Surgery Part A: Pulmonary Artery Reconstruction , Pp. 199-212 (14)

Akın Eraslan Balcı
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Lung Cancer Surgery Part B: Methods and Results of Extended Pulmonary Resections , Pp. 213-258 (46)

Akın Eraslan Balcı
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Lung Cancer Surgery Part C: Segmentectomy and Wedge Resection in the Surgical Treatment of NSCLC , Pp. 259-267 (9)

Ahmet Demirkaya and Kamil Kaynak
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Lung Cancer Surgery Part D: Lobectomies , Pp. 268-278 (11)

Kamil Kaynak and Ahmet Demirkaya
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Lung Cancer Surgery Part E: Pneumonectomy , Pp. 279-288 (10)

Ahmet Demirkaya, Kamil Kaynak and Ezel Ersen
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Lung Cancer Surgery Part F: Surgical Treatment Modalities for Pulmonary Metastases , Pp. 289-299 (11)

Mustafa Yüksel and Hasan Volkan Kara
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Lung Cancer Surgery Part G: Superior Sulcus Tumours , Pp. 300-310 (11)

Mustafa Yüksel and Hasan Volkan Kara
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Lung Cancer Surgery Part H: Interventional Bronchoscopy , Pp. 311-322 (12)

Sedat Altin
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Lung Cancer Surgery Part I: Carcinoid Tumours of the Lung , Pp. 323-346 (24)

Altuğ Koşar, Alpay Orki, Tülay Kayacan Örki and Bülent Arman
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Lung Cancer Surgery Part J: Bronchoplasty , Pp. 347-354 (8)

Kamil Kaynak, Ahmet Demirkaya and Burcu Kilic
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Lung Cancer Surgery Part K: Intraoperative Mediastinal Lymph Node Examination Techniques in Non-Small Cell Lung Cancer , Pp. 355-364 (10)

Mehmet Ali Bedirhan
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Oncologic Treatment of Non-Small Cell Lung Cancer Part A: Neoadjuvant Chemotherapy Options for Non-Small Cell Lung Carcinoma , Pp. 365-370 (6)

Ahmet Taner Sumbul and Ozgur Ozyilkan
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Oncologic Treatment of Non-Small Cell Lung Cancer Part B: Adjuvant Chemotherapy for Resected Non-Small Cell Lung Carcinoma , Pp. 371-376 (6)

Fatih Kose and Ozgur Ozyilkan
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Oncologic Treatment of Non-Small Cell Lung Cancer Part C: Radiation Therapy for Non-Small Cell Lung Cancer , Pp. 377-411 (35)

Cem Önal
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Alternatives to Surgical Resection for Non–Small Cell Lung Cancer , Pp. 412-436 (25)

Akın Eraslan Balcı
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Immunological Approach to Lung Cancer Part A: Immunology of Lung Cancer , Pp. 437-454 (18)

Fulya Ilhan
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Immunological Approach to Lung Cancer Part B: Immunological Therapies for Lung Cancer , Pp. 455-465 (11)

Ayşegül Atak Yücel
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The Oncological and Surgical Management of Small Cell Lung Cancer , Pp. 466-489 (24)

Akif Turna
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Pain Treatment in Thorax Malignities , Pp. 490-545 (56)

Selami Ateş Önal
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Palliative Care in Lung Cancer , Pp. 546-562 (17)

Selçuk Dinçer and Süleyman Özyalçin
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Index , Pp. 563-609 (47)

Akın Eraslan Balcı
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Foreword

Carcinoma of the lung is the leading cause of cancer deaths. The management of lung cancer involved a questionnaire prior to treatment. It contains questions asked when taking a medical history, when forming a differential diagnosis, when choosing treatment, when performing an operation and when planning a postoperative treatment. Physicians who worked on lung cancer, regardless of speciality, are constantly confronted with questions posed from patients, from their collegues and, most importantly, from within themselves.

These considerations are behind developing a new textbook of this nature and caused the motivation. The book edited by Prof. Balci provides a broad overview of the lung cancer surgery, clinical and molecular aspects and pathology of it.

This textbook is a good resource to pulmonary and critical care specialist and their trainees, as well as thoracic surgeons, oncologists, and pulmonary pathologists. Major objectives are to present a summation of the current knowledge and clinical concepts of the surgical management of lung cancer. The pathophysiological alterations produced and the correction of these by appropriate intervention are emphasized thorughout. Clinical features, pathological changes, surgical management, operative results and prognosis are included as integral part of the book.

We are most grateful to the numerous authors who put so many times into writing otustanding chapters. This book includes all the relevant and current information on lung cancer. Much information is completely updated. Although we believe that this book will provide a clear understanding of these manifestations, we invite our readers to inform us about differences of opinion they may have with its contents and areas that need improvment.

Yavuz Selim Ilhan
Euphrates University Hospital
Head of General Surgery Department
Elazig
Turkey


Preface

This book focuses on the lung cancer, which is the mostly encountered, and one of the most challenging malignant diseases of the world. Worldwide, the annual number of new cases of lung cancer is estimated at more than one million and is expected to increase to ten million in 2025. Fortunately, the political efforts to reduce the use of tobacco are getting increasing attention in many countries and the statistics are now showing the first positive results.

Over the last decade there have been several improvements and changes in the lung cancer management. Among the epidemiologic changes we see a change in the histopathologic pattern, with a relative decrease in squamous cell carcinoma and a rise in adenocarcinoma. Much research is attempting to identify biomarkers to predict a high risk for developing lung cancer. This will be important for implementing screening and prevention strategies. There is a steady improvement of the overall management of lung cancer based on an increasing use of combined modality therapy, consisting of surgery, chemotherapy, and radiotherapy applied concurrently or sequentially in early stage disease. Furthermore, new techniques are gaining ground, both within surgery and radiotherapy, and targeted medical therapy is being offered to more and more patients.

This book is not intended as a comprehensive textbook, but as a concise summary of advances in lung cancer clinical research and treatment for the clinician. The textbook brings up-to-date information about lung cancer, based on worldwide experience, for the use of the many physicians involved in this field.

All of the authors have been selected for their expertise and proven achievement in these challenging fields; I would like to sincerely thank all of them for participating with enthusiasm in this project. I hope that the different contributions will help the readers to fill in the gaps and stimulate them for future developments.

Akin Eraslan Balci
Euphrates University
School of Medicine
Department of Thoracic Surgery
Elazig
Turkey

List of Contributors

Editor(s):
Akin E. Balci
Department of Thoracic Surgery
Euphrates University, School of Medicine
Elazig
Turkey




Contributor(s):
Abdurrahman Y. E. Oğur
Department of Radiology
Euphrates University, School of Medicine
Elazig
Turkey


Ozgur Ozyilkan
Division of Medical Oncology
Baskent University, Research and Treatment Center
Adana
Turkey


Akif Turna
Department of Thoracic Surgery
Istanbul University Cerrahpasa Medical Faculty
Kocamustafapasa/Fatih Istanbul
Turkey


Akın E. Balcı
Department of Thoracic Surgery
IEuphrates University School of Medicine
Elazig
Turkey


Bülent Arman
Department of Thoracic Surgery
Maltepe University School of Medicine
İstanbul
Turkey


Mehmet A. Bedirhan
Yedikule Hospital for Chest Disease, Chief of Surgery
İstanbul
Turkey


Cem Onal
Adana Research and Treatment Center, Deparment of Radiation Oncology
Baskent University, Faculty of Medicine
Yuregir/ Adana
Turkey


Ahmet Hatipoğlu
Department of Thoracic Surgery
Baskent University Faculty of Medicine
Ankara Teaching and Medical Research Center
Bahcelievler/Ankara
Turkey


Ebru Ö. Etem
Department of Medical Biology
Firat University, Faculty of Medicine
Elazig
Turkey


Fulya Ilhan
Department of Immunology
Euphrates University, Faculty of Medicine
Elazığ
Turkey


Gamze Kirkil
Department of Respiratory Diseases
uphrates University
Elazığ
Turkey


Günay Aydin
Department of Respiratory Diseases
İstanbul University, Cerrahpasa Medical School
Turkey


Ibrahim Ozercan
Department of Pathology
Euphrates University, School of Medicine
Elazig
Turkey


Kamil Kaynak
Department of Thoracic Surgery
Istanbul University Cerrahpasa Medical Faculty
Kocamustafapasa/Fatih
Istanbul
Turkey


Mehmet O. Özyurtkan
Department of Thoracic Surgery
Firat University, Faculty of Medicine
Elazığ
Turkey


Selami A. Önal
Department of Pain
Euphrates University
Elazig
Turkey


Süleyman Özyalçın
Depratment of Algology
Istanbul University, Istanbul Faculty of Medicine
Monoblok, Capa
Istanbul
Turkey


Tansel A. Balci
Department of Nuclear Medicine
Firat Euphrates University School of Medicine
Elazig
Turkey


Tulın Cagatay
Department of Pulmonary diseases
Istanbul University, Istanbul Medical Faculty, CAPA
Istanbul
Turkey


Murat Kara
Department of Medical Genetics School of Medicine
Euphrates University
Elazig
Turkey


Semen Onder
Department of Pathology
Euphrates University, School of Medicine
Elazig
Turkey


Gulfer Okumus
Department of Pulmonary Diseases
Istanbul University, Istanbul Medical Faculty, CAPA
Istanbul
Turkey


Serdar Erturan
Department of Respiratory Diseases
İstanbul University, Cerrahpasa Medical School
Turkey


Dalokay Kiliç
Department of Thoracic Surgery, Ankara Teaching and Medical Research Center
Baskent University Faculty of Medicine, Bahcelievler
Ankara
Turkey


Alper Findikçioğlu
Department of Thoracic Surgery, Ankara Teaching and Medical Research Center
Baskent University Faculty of Medicine, Bahcelievler
Ankara
Turkey


Ahmet K. Poyraz
Department of Radiology
Euphrates University, School of Medicine
Elazig
Turkey


Ahmet Demirkaya
Department of Thoracic Surgery
Istanbul University, Cerrahpasa Medical Faculty
Kocamustafapasa/Fatih
Istanbul
Turkey


Ezel Ersen
Department of Thoracic Surgery
State Hospital
Kocaeli
Turkey


Hassan V. Kara
Department of Thoracic Surgery
Marmara University, School of Medicine
İstanbul
Turkey


Alpay Orki
Department of Thoracic Surgery
Maltepe University School of Medicine
İstanbul
Turkey


Altuğ Koşar
Thoracic Surgery Department
Lutfi Kirdar Research and Training Hospital
Istanbul
Turkey


Burcu Kilic
Department of Thoracic Surgery
Istanbul University, Cerrahpasa Medical Faculty
Turkey


Fatih Kose
Division of Medical Oncology
Baskent University, Research Center
Adana
Turkey


Ahmet T. Sumbul
Division of Medical Oncology
Baskent University, Research Center
Adana
Turkey


Yücel Ayşegül A.
Department of Immunology
Gazi University, Faculty of Medicine, Beşevler
Ankara
Turkey


Selçuk Dinçer
Depratment of Algology
Istanbul University, Istanbul Faculty of Medicine
Monoblok, CAPA
Istanbul
Turkey


Sedat Altin
Yedikule Chest Disease Hospital
İstanbul
Turkey




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