Neurobiology of Mood Disorders


by

Bruno P. Guiard, Eliyahu Dremencov

DOI: 10.2174/97816080546711140101
eISBN: 978-1-60805-467-1, 2013
ISBN: 978-1-60805-578-4



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This monograph is a collection of selected articles on the subject of mood disorders such as depression and schizophrenia. It is divid...[view complete introduction]

Table of Contents

PREFACE: NEUROBIOLOGY OF MOOD DISORDERS

- Pp. i

Bruno P. Guiard and Eliyahu Dremencov

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LIST OF CONTRIBUTORS

- Pp. ii

Bruno P. Guiard and Eliyahu Dremencov

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INTRODUCTION: THE DEPRESSED PATIENT IN A NEUROBIOLOGICAL WORLD: HISTORY, NEUROPHILOSOPHY AND EVIDENCE BASED PSYCHIATRY

- Pp. iii-xviii (16)

JAKOB KORF

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BRAIN MICRODIALYSIS IN KNOCKOUT MICE: DRAWBACKS AND ADVANTAGES TO STUDY THE ROLE OF 5-HT<sub>1A</sub> AND 5-HT<sub>1B</sub> AUTORECEPTORS IN THE MECHANISM OF ACTION OF ANTIDEPRESSANTS

- Pp. 3-22 (20)

ALAIN M. GARDIER

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OPTOGENETIC INVESTIGATION OF CIRCUITS UNDERLYING AFFECTIVE BEHAVIOR

- Pp. 23-33 (11)

MAZEN A. KHEIRBEK

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THE SEROTONERGIC SYSTEM AS A TARGET FOR POSITRON EMISSION TOMOGRAPHY LIGANDS APPLICATIONS IN AFFECTIVE DISORDERS

- Pp. 34-57 (24)

ANNIEK K.D. VISSER, AREN VAN WAARDE, FOKKO J. BOSKER, JOHAN A. DEN BOER and RUDI A. DIERCKX

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PATHOPHYSIOLOGY OF MOOD DISORDERS: PHARMACOGENETIC ASPECTS

- Pp. 58-106 (49)

CHIARA FABBRI, STEFANO PORCELLI and ALESSANDRO SERRETTI

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PATHOPHYSIOLOGY OF MOOD DISORDERS: NORADRENERGIC MECHANISMS

- Pp. 107-126 (20)

ELIYAHU DREMENCOV

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PATHOPHYSIOLOGY OF MOOD DISORDERS: DOPAMINERGIC MECHANISMS

- Pp. 127-138 (12)

OLGA CHERNOLOZ

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ROLE OF PREFRONTAL CORTEX IN THE PATHOPHYSIOLOGY AND TREATMENT OF DEPRESSION AND SCHIZOPHRENIA

- Pp. 139-173 (35)

XAVIER LÓPEZ-GIL, LAURA JIMÉNEZ-SÁNCHEZ and ALBERT ADELL

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PATHOPHYSIOLOGY OF MOOD DISORDERS: NEUROENDOCRINE MECHANISMS

- Pp. 174-209 (36)

CHRISTOPHER L. LA RICHE, DAVIDE PRESTIA, SAMANTHA G. BLOCK and CHARLES B. NEMEROFF

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ROLE OF HIPPOCAMPAL NEUROGENESIS IN THE PATHOPHYSIOLOGY AND TREATMENT OF DEPRESSION

- Pp. 210-233 (24)

BENJAMIN ADAM SAMUELS, INDIRA DAVID, QUENTIN RAINER, ALAIN MICHEL GARDIER, RENÉ HEN and DENIS JOSEPH DAVID

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NEW STRATEGIES FOR THE TREATMENT OF MOOD DISORDERS: THE TRIPLE REUPTAKE INHIBITORS

- Pp. 234-253 (20)

GAËL QUESSEVEUR and BRUNO GUIARD

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NEW STRATEGIES FOR THE TREATMENT OF MOOD DISORDERS: VAGUS NERVE STIMULATION FOR THE TREATMENT OF RESISTANT DEPRESSION

- Pp. 254-270 (17)

STELLA MANTA, MOSTAFA EL MANSARI and PIERRE BLIER

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INDEX

- Pp. 271-276 (6)

Bruno P Guiard and Eliyahu Dremencov

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Preface

It was our honor and pleasure to prepare this ebook entitled “Neurobiology of Mood Disorders”. The World Health Organization considers mood disorders as fourth major reason for disability and they will become the second major reason for disability by 2020. Mood disorders have complex etiology with variable clinical symptoms. This may result from the involvement of abnormalities at the genetic, molecular and cellular levels. As a result, multidisciplinary research approaches have been used to investigate the pathophysiology of mood disorders and the mechanism of action of antidepressant drugs and mood stabilizers. This ebook is divided to introduction and three parts. The first part addresses different research methods employed by modern neuropsychopharmacology. Several multidisciplinary approaches, from genetically-modified animal models to, neuroimaging in human are considered with a particular attention on optogenetic method. The second part aims to address the molecular and neuronal aspects of mood disorders. The third part focuses on the current genetic, pharmacological and non- pharmacological strategies used to improve the treatment of mood disorders. This ebook might be out of interest for broad spectrum of researchers and clinicians working in the area of neuroscience and mental health. Undergraduate and graduate students studying life and medical science disciplines, and postdoctoral trainees and young physicians in training, specializing in basic or clinical neuroscience, may found this book beneficial for their education programs. We would like to thank Bentham Science Publishers for their kind invitation, to the authors for their contributions, and for the reviewers that helped us to prepare this ebook. A very warm acknowledgement should be given Prof. Jakob Korf (University of Groningen Medical Center) for writing introduction to this ebook, to Mr. Sergey Nikolsky (Daatz, Groningen), for his help with preparation of this ebook to print, and to Mrs. Aniza Naveed (Bentham Science e-Books Publication Manager), who coordinated this project.

Bruno P. Guiard
Faculty of Pharmacy
University Paris South XI
Châtenay-Malabry
Paris

&

Eliyahu Dremencov
Institute of Molecular Physiology and Genetic
Slovak Academy of Science
Bratislava, Slovakia, and
Neuroken Consulting
Groningen, The Netherlands

List of Contributors

Editor(s):
Bruno P. Guiard
Faculty of Pharmacy
University Paris South XI
Châtenay-Malabry
France


Eliyahu Dremencov
Eliyahu Dremencov Slovak Academy of Sciences
Bratislava
Slovakia
/
Neuroken Consulting
Healthy Ageing Campus Netherlands
Groningen
The Netherlands




Contributor(s):
Albert Adell
Instituto de Investigaciones Biomédicas de Barcelona
CSIC (IDIBAPS), and Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM)
Barcelona
Spain


Pierre Blier
University of Ottawa
Institute of Mental Health Research
Ottawa
Ontario
Canada


Samanha G. Blok
University of Miami
Miller School of Medicine
Miami
Florida
USA


Fokko J. Bosker
University of Groningen Medical amtlib
Groningen
The Netherlands
/
Chernoloz
Olga Toronto, Ontario
Canada


Denis J. David
University Paris South
Châtenay-Malabry
France


Indira David
University Paris South
Châtenay-Malabry
France


Johan A. den Boer
University of Groningen Medical Center
Groningen
The Netherlands


Rudi A. Dierckx
University of Groningen Medical Center
Groningen
The Netherlands


Eliyahu Dremencov
Department of Neuroscience
University of Groningen Medical Center
Neuroken Consulting
Ageing Campus Netherlands
Groningen
the Netherlands
/
Institute of Molecular Physiology and Genetics
Slovak Academy of Sciences
Bratislava
Slovakia


Mostafa el Mansari
University of Ottawa
Institute of Mental Health Research
Ottawa
Ontario
Canada


Chiara Fabbri
Institute of Psychiatry
University of Bologna
Bologna
Italy


Alain M. Gardier
University Paris South
Châtenay-Malabry
France


Bruno P. Guiard
University Paris South
Châtenay-Malabry
France


René Hen
University Paris South
Châtenay-Malabry
France


Laura Jiménez-Sánchez
Instituto de Investigaciones Biomédicas de Barcelona
CSIC (IDIBAPS), and Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM)
Barcelona
Spain


Mazen A. Kheirbek
Columbia University
New York
NY, 10032
USA


Jakob Korf
University of Groningen Medical Center
Groningen
The Netherlands


Christopher L. La Riche
University of Miami
Miller School of Medicine
Miami
Florida
USA


Xavier López-Gil
Instituto de Investigaciones Biomédicas de Barcelona
CSIC (IDIBAPS), and Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM)
Barcelona
Spain


Stella Manta
Laval University
Institut Universitaire en Santé Mentale de Québec (IUSMQ)
Québec-City
Québec
Canada


Charles B. Nemeroff
University of Miami
Miller School of Medicine
Miami
Florida
USA


Stefano Porcelli
Institute of Psychiatry
University of Bologna
Bologna
Italy


Davide Prestia
University of Miami
Miller School of Medicine
Miami
Florida
USA


Gaël Quesseveur
University Paris South
Châtenay-Malabry
France


Quentin Rainer
University Paris South
Châtenay-Malabry
France


Benjamin A. Samuels
University Paris South
Châtenay-Malabry
France


Alessandro Serretti
Institute of Psychiatry
University of Bologna
Bologna
Italy


Aren van Waarde
University of Groningen Medical Center
Groningen
The Netherlands


Anniek K.D. Visser
University of Groningen Medical Center
Groningen
The Netherlands




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