Frontiers in Clinical Drug Research - CNS and Neurological Disorders

Volume 1

by

Atta-ur-Rahman

DOI: 10.2174/97816080575801130101
eISBN: 978-1-60805-758-0, 2013
ISBN: 978-1-60805-759-7
ISSN: 2214-7527

  
  




Frontiers in Clinical Drug Research - CNS and Neurological Disorders is an eBook series that brings updated reviews to readers interes...[view complete introduction]
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Table of Contents

Preface, Pp. i-ii (2)

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List of Contributors, Pp. iii-iv (2)

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Potential Use of Antidepressants as Therapies for Drug Use Disorders, Pp. 3-37 (35)

Peter R. Kufahl, Piroska Barabas, Casey Halstengard and M. Foster Olive

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Advances in Therapies for Multiple Sclerosis, Pp. 38-68 (31)

Naila Makhani and Eluen A. Yeh

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Antisense Oligonucleotides Therapy: A New Potential Tool in the Treatment of Cerebral Gliomas, Pp. 69-115 (47)

Gerardo Caruso, Maria Caffo, Maria Angela Pino and Giuseppe Raudino

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A Novel Pharmacological Approach for the Treatment of Posttraumatic Stress Disorder Using Cognitive Enhancers, Pp. 116-134 (19)

Shigeto Yamamoto and Shigeru Morinobu

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Lactate Metabolism as a New Target for the Therapeutics of Schizophrenia, Pp. 135-148 (14)

Takashi Uehara and Tomiki Sumiyoshi

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Principles and Current Issues of Antiepileptic Drug Therapy, Pp. 149-229 (81)

Laura Rosa Pisani, Vincenzo Belcastro, Giancarla Oteri and Francesco Pisani

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Pharmacological Treatment of Cognitive Impairment in Schizophrenia: A Critical Review of the Clinical Effects of Current and Developing Drugs, Pp. 230-252 (23)

Seiya Miyamoto

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Current Pharmacologic Treatments in Impaired Social Interaction in Autism Spectrum Disorders, Pp. 253-270 (18)

Kunio Yui

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Pharmacological Treatments, Related Clinical Characteristics and Brain Function in Adolescent Depression, Pp. 271-282 (12)

Kunio Yui

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Index, Pp. 283-294 (12)

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Preface

Frontiers in Clinical Drug Research - CNS and Neurological Disorders represents comprehensive advances in the development of pharmaceutical agents for the treatment of central nervous system (CNS) and other nerve disorders. It covers a range of topics including the medicinal chemistry, pharmacology, molecular biology and biochemistry of contemporary molecular targets involved in neurological and CNS disorders. The reviews are mainly focused on clinical and therapeutic aspects of novel drugs intended for these targets.

Frontiers in Clinical Drug Research - CNS and Neurological Disorders is a valuable resource for pharmaceutical scientists and postgraduate students seeking updated and critical information for developing clinical trials and devising research plans in the field of neurology. The contributions by leading researchers in the field shed light on a variety of therapeutic areas such as:

- Advances in the treatment of cerebral gliomas, multiple sclerosis and schizophrenia,

- Different uses of antidepressants in treating drug users and adolescents suffering from depression,

- Researches on epilepsy and autism spectrum disorder therapy.

In the first chapter, Peter R. Kufahl et al. have discussed the potential use of antidepressants as therapies for drug use disorders. They have provided an overview of preclinical and clinical research and explained the animal models used to obtain information about the treatment potential of various pharmaceutical compounds. Primary neurotransmitter targets and pharmacokinetic aspects of the therapeutic compounds are presented in the chapter. In chapter two, Eluen A. Yeh and Naila Makhani describe the mechanism of action, efficacy data, and side effect profile of multiple sclerosis therapies with a focus on the newly emerging agents. Gerardo Caruso et al. discuss antisense oligonucleotides therapy as a new potential tool in the treatment of cerebral gliomas in chapter three.

In chapter four, Shigeto Yamamoto and Shigeru Morinobu focus on D-cycloserine (DCS), a partial agonist of N-methyl-D-aspartate (NMDA) receptors, and on histone deacetylase (HDAC) inhibitors. They have provided an overview of the effects of these agents, the clinical implications and drawbacks associated with their use, and directions for future research. Lactate appears to play an important role in energy production.Takashi Uehara and Tomiki Sumiyoshi provide a comprehensive overview of lactate metabolism as a new target for the treatment of schizophrenia in chapter five.

In chapter six, Francesco Pisani et al. review the principles and current issues of antiepileptic drug therapy. Schizophrenia is a devastating mental disorder characterized by positive, negative, affective, and cognitive symptoms. In chapter seven, Seiya Miyamoto provides a review on the effects of currently available antipsychotics and cognitive enhancers under development on cognition in schizophrenia.

In chapter eight Kunio Yui describe autism spectrum disorders (ASD) as a neurodevelopmental disorder with reduced cortical functional connectivity relating to social cognition. The current treatment of ASD and future directions of research in the light of the present understanding of this disease is discussed. In another article the same author presents the current state of development of therapeutics for treatment of adolescent depression.

I hope that the readers will find these reviews valuable and thought provoking so that they trigger further research in the quest for the development of pharmaceutical agents for the treatment of central nervous system (CNS) and other nerve disorders.

I am grateful for the timely efforts made by the editorial personnel, especially Mr. Mahmood Alam (Director Publications) and Mr. Shehzad Naqvi (Senior Manager Publications) at Bentham Science Publishers

Atta-ur-Rahman, FRS
Kings College
University of Cambridge
Cambridge

UK

List of Contributors

Editor(s):
Atta-ur-Rahman FRS
Honorary Life Fellow, Kings College
University of Cambridge
UK




Contributor(s):
Casey Halstengard
Department of Psychology
Arizona State University, Tempe
Arizona
USA


Eluen A. Yeh
Division of Neurology
Hospital for Sick Children and University of Toronto
ON, M5G 1X8
Canada


Francesco Pisani
Department of Neurosciences
University of Messina
Messina
Italy


Gerardo Caruso
Department of Neuroscience, Neurosurgical Clinic
University of Messina
Messina
Italy


Giancarla Oteri
Department of Neurosciences
University of Messina
Messina
Italy


Giuseppe Raudino
Department of Neuroscience, Neurosurgical Clinic
University of Messina
Messina
Italy


Kunio Yui
Research Institute of Pervasive Developmental Disorders
Ashiya University Graduate School of Education
Hyogo
Japan


Laura Rosa Pisani
Department of Neurosciences
University of Messina
Messina
Italy


M. Foster Olive
Department of Psychology
Arizona State University, Tempe
Arizona
USA


Maria Angela Pino
Department of Neuroscience
Neurosurgical Clinic, University of Messina
Messina
Italy


Maria Caffo
Department of Neuroscience
Neurosurgical Clinic, University of Messina
Messina
Italy


Naila Makhani
Division of Neurology
Hospital for Sick Children and University of Toronto
ON, M5G 1X8
Canada


Peter R. Kufahl
Department of Psychology
Arizona State University, Tempe
Arizona
USA


Piroska Barabas
Department of Psychology
Arizona State University, Tempe
Arizona
USA


Seiya Miyamoto
Department of Neuropsychiatry
St. Marianna University School of Medicine, Kawasaki
Kanagawa
Japan


Shigeru Morinobu
Department of Psychiatry and Neurosciences
Applied Life Sciences Institute of Biomedical & Health Sciences
Hiroshima University
Hiroshima
Japan


Shigeto Yamamoto
Department of Psychiatry and Neurosciences
Applied Life Sciences Institute of Biomedical & Health Sciences
Hiroshima University
Hiroshima
Japan


Takashi Uehara
Department of Neuropsychiatry
University of Toyama Graduate School of Medicine and Pharmaceutical Science
Toyama
Japan


Tomiki Sumiyoshi
Department of Neuropsychiatry
University of Toyama Graduate School of Medicine and Pharmaceutical Sciences
Toyama
Japan


Vincenzo Belcastro
Department of Neurosciences
University of Messina
Messina
Italy




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