Frontiers in Clinical Drug Research -CNS and Neurological Disorders

Volume 2

by

Atta-ur-Rahman

DOI: 10.2174/97816080577571130201
eISBN: 978-1-60805-775-7, 2013
ISBN: 978-1-60805-776-4
ISSN: 2214-7527 (Online)



Recommend this eBook to your Library



Frontiers in Clinical Drug Research - CNS and Neurological Disorders is an eBoo...[view complete introduction]

Table of Contents

Foreword

- Pp. i

Ferid Murad

Download Free

Preface

- Pp. ii-iii (2)

Atta-ur-Rahman

Download Free

List of Contributors

- Pp. iv-vii (4)

Atta-ur-Rahman

Download Free

Schizophrenia Pharmacotherapy: Emerging Approaches

- Pp. 3-27 (25)

Jaime Almeida and Christian Bouwkamp

View Abstract Purchase Chapter

GABAergic Neurotransmission and Alzheimer Disease: An Emerging Therapeutic Scenario?

- Pp. 28-54 (27)

Mauricio O. Nava-Mesa, Lydia Jiménez-Diaz, Javier Yajeya and Juan D. Navarro-López

View Abstract Purchase Chapter

Plasma Exchange for Severe Attacks in the Spectrum of Central Demyelinating Disorders

- Pp. 55-109 (55)

Mickael Bonnan and Philippe Cabre

View Abstract Purchase Chapter

Neurochemistry and Neuropharmacology of Essential Tremor

- Pp. 110-142 (33)

Hortensia Alonso-Navarro, Félix Javier Jiménez-Jiménez, Elena García- Martín and José A.G. Agúndez

View Abstract Purchase Chapter

Intraoperative Somatosensory and Motor Evoked Potential Recording and Electroencephalographic Monitoring Usefulness During Aneurysm Surgery

- Pp. 143-180 (38)

Soheila Raysi Dehcordi, Donatella Trovarell, Sabino Luzzi, Alfonso M. Marrelli, Alessandro Ricci, Maria G. Cifone and Renato Galzio

View Abstract Purchase Chapter

Multiple Sclerosis: Drugs in Advanced Clinical Development

- Pp. 181-297 (117)

Rosella Ciurleo, Placido Bramanti, Letteria Spadaro and Silvia Marino

View Abstract Purchase Chapter

Interactions Between Neurological Disorders and Cancer: Recent Advances in Drug Discovery

- Pp. 298-321 (24)

Seung-Shick Shin, Brian A. Wall and Suzie Chen

View Abstract Purchase Chapter

Fight Against Angiogenesis-Related Blindness: Focusing on Diabetic Retinopathy

- Pp. 322-349 (28)

Dong Hyun Jo, Jin Hyoung Kim and Jeong Hun Kim

View Abstract Purchase Chapter

Index

- Pp. 350-363 (14)

Atta-ur-Rahman

Download Free

Foreword

Frontiers in Clinical Drug Research - CNS and Neurological Disorders covers important advances in the field of drug development with particular focus on research on drugs in advanced stages of development, clinical trials and applications. This Volume published under the editorship of Prof. Atta-ur-Rahman aims at providing readers with an update on contemporary research. The research articles are comprehensive and have been written by an impressive group of authors, most of whom are well known for their own contributions in the field of drug research.

This book should be of significant interest to Ph.D. students and established researchers. I commend the editor, Prof. Atta-ur-Rahman, and all the contributors for this well written volume which highlights the quest for a cure for CNS and Neurological Disorders.

Ferid Murad
(Nobel Prize Physiology and Medicine 1998)
University Professor
Director of the Cell Signaling Institute
George Washington University
Washington, DC, USA


Preface

Frontiers in Clinical Drug Research - CNS and Neurological Disorders presents recent advances in the development of pharmaceutical agents for the treatment of central nervous system (CNS) and other nerve disorders. It covers a range of topics including the medicinal chemistry, pharmacology, molecular biology and biochemistry of contemporary molecular targets involved in neurological and CNS disorders. The chapters are written by authorities in the field and are mainly focused on clinical and therapeutic aspects of novel drugs intended for these targets.

The book is a valuable resource for pharmaceutical scientists and postgraduate students seeking updated and critically important information for devising research plans in the field of neurology. The contributions by leading researchers in the field shed light on a variety of therapeutic areas such as the treatment of multiple sclerosis and schizophrenia, neurochemistry of tremors, relationship between GABA and Alzheimer’s disease therapy as well as between neurological diseases and cancer, and recent researches on angiogenesis-related blindness.

In chapter 1, Jaime Almeida and Christian Bouwkamp present the drugs presently under development for schizophrenia, from the earlier stages of development to phase III clinical trials. They discuss the most promising strategies and targets currently under investigation for the development of novel schizophrenia drugs. In chapter 2, Mauricio O. Nava-Mesa et al. have highlighted the role of GABAergic synapses towards the therapy of Alzheimer´s disease (AD). Alzheimer´s disease is characterized by the deposition of amyloid-ß peptide (Aß) and microtubule-binding protein tau which forms Amyloid plaques and neurofibrillary tangles. These Aß plaques are pivotal targets for drug design studies to improve dysfunctions that become prevalent with age. The hippocampus, septum, amygdala or entorhinal cortex in the brain have rich reciprocal glutamatergic, cholinergic and GABAergic connections. The relationships among them directly affect learning and memory processes. These aspects are discussed.

Mickael Bonnan and Philippe Cabre have focused on the new indication of PLEX in the full spectrum of demyelinating disorders of central nervous system in chapter 3. They have briefly reviewed the spectrum of disorders (MS, NMO, ADEM, Balo) and demonstrated how the humoral part of inflammation, according to the underlying disease, is especially suitable to be eliminated by plasma exchange. In chapter 4, Hortensia Alonso-Navarro et al. discuss the pharmacological treatments that have demonstrated the greatest efficacy for essential tremor. These are the beta-blockers propranolol and primidone. They have also described the alterations of the dopaminergic, serotonergic, GABAergic, noradrenergic and adrenergic systems.

Soheila Raysi Dehcordi et al. in chapter 5 report the experiences of the authors in using neurophysiopathological monitoring during aneurysm surgery with particular reference to the evoked potential and EEG changes in response to surgical and anaesthetic variables; In chapter 6, Rosella Ciurleo et al. have discussed the different types of multiple sclerosis and the therapies that are under development. In the next chapter Seung-Shick Shin et al. present the implications of glutamatergic signaling through glutamate receptors and transporters in cancers in comparison to neuronal disorders as well as recent clinical approaches using Riluzole, an FDA approved glutamate release inhibitor for ALS patients in human cancers. In the last chapter Dong Hyun Jo et al. evaluate the treatment options for diabetic retinopathy (DR).

I hope that the readers will find these reviews valuable and thought provoking so that they may trigger further research in the quest for the development of pharmacological agents used for the treatment of neurological disorders.

I am grateful for the timely efforts made by the editorial personnel, especially Mr. Mahmood Alam (Director Publications), and Mr. Shehzad Naqvi (Senior Manager Publications), at Bentham Science Publishers.

Atta-ur-Rahman, FRS
Kings College
University of Cambridge
Cambridge
UK

List of Contributors

Editor(s):
Atta-ur-Rahman FRS
Honorary Life Fellow, Kings College
University of Cambridge
UK




Contributor(s):
Alessandro Ricci
Operative Unit of Neurosurgery
San Salvatore HospitalL’Aquila
L’Aquila
Italy


Alfonso M. Marrelli
Operative Unit of Neurosurgery
San Salvatore HospitalL’Aquila
L’Aquila
Italy


Brian A. Wall
Susan Lehman Cullman Laboratory for Cancer Research
Ernest Mario School of Pharmacy
Rutgers, the State University of New Jersey
Piscataway
NJ, 08854
USA


Christian Bouwkamp
Department of Neurobiological Psychiatry
Erasmus MC Rotterdam
The Netherlands


Donatella Trovarelli
Operative Unit of Neurosurgery
San Salvatore HospitalL’Aquila
L’Aquila
Italy


Dong Hyun Jo
Fight Against Angiogenesis-Related Blindness (FARB) Laboratory
and Department of Ophthalmology
College of Medicine
Seoul National University
Seoul, 110-744
Republic of Korea


Elena García-Martín
Department of Biochemistry and Molecular Biology
University of Extremadura
Cáceres, Spain and AMGenomics
Edificio Tajo, Avda. de la Universidad s/n
Cáceres
Spain


Félix Javier Jiménez-Jiménez
Section of Neurology
Hospital Universitario del Sureste
Arganda del Rey
Madrid
Spain


Hortensia Alonso-Navarro
Section of Neurology
Hospital Universitario del Sureste
Arganda del Rey
Madrid
Spain


Jaime Almeida
Department of Neurobiological Psychiatry
Erasmus MC Rotterdam
The Netherlands


Javier Yajeya
Department of Physiology and Pharmacology
University of Salamanca
Salamanca
Spain


Jeong Hun Kim
Fight Against Angiogenesis-Related Blindness (FARB) Laboratory
Department of Ophthalmology, College of Medicine
Seoul National University
Seoul, 110-744
Republic of Korea


Jin Hyoung Kim
Fight Against Angiogenesis-Related Blindness (FARB) Laboratory and Department of Ophthalmology
College of Medicine, Seoul National University
Seoul, 110-744
Republic of Korea


José A.G. Agúndez
AMGenomics, Edificio Tajo, Avda. de la Universidad s/n and Department of Pharmacology
University of Extremadura
Cáceres
Spain


Juan D. Navarro-López
Neurophysiology and Behavior Lab
School of Medicine of Ciudad Real
University of Castilla-La Mancha
Ciudad Real
Spain


Letteria Spadaro
IRCCS Centro Neurolesi “Bonino-Pulejo
Messina
Spain


Lydia Jiménez-Diaz
Neurophysiology and Behavior Lab
School of Medicine of Ciudad Real
University of Castilla-La Mancha
Ciudad Real
Spain


Maria G. Cifone
Department of Health
Life and Environmental Sciences
University of L’Aquila
L’Aquila
Italy


Mauricio O. Nava-Mesa
Neurophysiology and Behavior Lab
School of Medicine of Ciudad Real
University of Castilla-La Mancha
Ciudad Real
Spain


Mickael Bonnan
Service de Neurologie
Hôpital F. Mitterrand
Pau
France


Philippe Cabre


Placido Bramanti
IRCCS Centro Neurolesi “Bonino-Pulejo”
Messina
Italy


Renato Galzio
Department of Health, Life and Environmental Sciences
University of L’Aquila
and Operative Unit of Neurosurgery
San Salvatore Hospital
L’Aquila
Italy


Rosella Ciurleo
IRCCS Centro Neurolesi “Bonino-Pulejo”
Messina
Italy


Sabino Luzzi
Operative Unit of Neurosurgery
San Salvatore Hospital
L’Aquila
Italy


Seung-Shick Shin
The Cancer Institute of New Jersey
195 Little Albany Street
New Brunswick
NJ, 08903
USA


Silvia Marino
IRCCS Centro Neurolesi “Bonino-Pulejo”
Messina
Italy


Soheila Raysi Dehcordi
Department of Health, Life and Environmental Sciences
University of L’Aquila
L’Aquila
Italy


Suzie Chen
The Cancer Institute of New Jersey
195 Little Albany Street
New Brunswick
NJ, 08903
USA
/
Susan Lehman Cullman Laboratory for Cancer Research
Ernest Mario School of Pharmacy
Rutgers, The State University of New Jersey
Piscataway
NJ, 08854
USA




Advertisement


Related Journals



Related Books



Webmaster Contact: urooj@benthamscience.org Copyright © 2016 Bentham Science