Frontiers in Clinical Drug Research- Central Nervous System

Volume 1

by

Atta-ur-Rahman

DOI: 10.2174/97816080577951130101
eISBN: 978-1-60805-779-5, 2013
ISBN: 978-1-60805-780-1
ISSN: 2467-9623 (Print)
ISSN: 2214-6318 (Online)



Recommend this eBook to your Library



Frontiers in Clinical Drug Research – Central Nervous System presents the lates...[view complete introduction]

Table of Contents

Foreword

- Pp. i

Ferid Murad

Download Free

Preface

- Pp. ii-iii (2)

Atta-ur-Rahman

Download Free

List of Contributors

- Pp. iv-v (2)

Atta-ur-Rahman

Download Free

Agonists and Allosteric Modulators of G Protein-Coupled Receptors as Promising Psychotropic Drugs

- Pp. 3-43 (41)

Yuji Odagaki

View Abstract Purchase Chapter

Central Glia as Prospective Targets in Chronic Pain

- Pp. 44-60 (17)

Romain-Daniel Gosselin

View Abstract Purchase Chapter

Spinal Cord Injury: Clinical Trials and Translational Tribulations

- Pp. 61-99 (39)

Simon Harris, Jared Wilcox and Michael G. Fehlings

View Abstract Purchase Chapter

Peptide Neurotoxins Targeting Voltage-Gated Ion Channels and Their Therapeutic Implications

- Pp. 100-165 (66)

Seungkyu Lee and Sun W. Hwang

View Abstract Purchase Chapter

Drugs Targeting Microglial Activation in Hypoxic Damage to the Developing White Matter

- Pp. 166-228 (63)

Gurugirijha Rathnasamy, Madhuvika Murugan, Eng-Ang Ling and Charanjit Kaur

View Abstract Purchase Chapter

Index

- Pp. 229-245 (17)

Atta-ur-Rahman

Download Free

Foreword

Frontiers in Clinical Drug Research – Central Nervous System covers important advances in the field of drug development with particular focus on research on drugs in advanced stages of development, clinical trials and applications. This Volume published under the editorship of Prof. Atta-ur-Rahman aims at providing readers with an update on contemporary research. The research articles are comprehensive and have been written by an impressive group of authors, most of whom are well known for their own contributions in the field of drug research. This book should be of significant interest to Ph.D. students and established researchers. I commend the editor, Prof. Atta-ur-Rahman, and all the contributors for this well written volume which highlights the quest for a cure for Neurological disease and related disorders.

Ferid Murad
(Nobel Prize Physiology and Medicine 1998)
George Washington University Washington
DC, USA


Preface

Frontiers in Clinical Drug Research – Central Nervous System presents the latest researches on the Central Nervous System (CNS). The contributions by leading researchers in the field shed light on the development and pathophysiology of the brain and spinal cord, physiological sites of drug action in the CNS and clinical findings on drugs used to treat CNS defects due to injury or impaired development. The book also highlights other aspects of CNS medicine such as pain medicine, stem cell research, pharmacology, toxicology and translational models in animals.

In the first chapter, Odagaki has provided an update of the recent development of psychoactive agents that act as agonists or allosteric modulators at several GPCR subtypes. These are potentially useful as therapeutic drugs for mental disorders. In Chapter 2 Gosselin present the promising recent developments in the quest of modulators of glial activity, particularly emphasizing the hurdles embodied by their pharmacodynamics and pharmacokinetics specificities. Particular attention is given to neuropathic pain owing to the important literature available in the field.

Spinal Cord Injury (SCI) is a common cause of neurological morbidity and mortality, particularly affecting young adults. In Chapter 3 Fehlings et al. discuss the potential of ion-channel blockers, targeted therapeutics and monoclonal antibodies. The experiences of human SCI stem cell trials are critically appraised and a novel therapeutic target of central pattern gait generator stimulation in the process of neuro-rehabilitation is proposed. Lee and Hwang present the molecular and functional characteristics of the peptide neurotoxins targeting voltage-gated ion channels in the nervous system in chapter 4. They also discuss the current status of research and development. In the last chapter Kaur et al. have summarized the currently available and potential new drugs along with their mechanism of action underlying suppression of microglial activation for the treatment of White Matter Damage (WMD) in the developing brain.

I hope that the readers will find these reviews valuable and thought provoking so that they trigger further research in the quest for the development of pharmacological agents used for the treatment of allergies.

I am grateful for the timely efforts made by the editorial personnel, especially Mr. Mahmood Alam (Director Publications) and Miss Maria Baig at Bentham Science Publishers.

Atta-ur-Rahman, FRS
Honorary Life Fellow
Kings College
University of Cambridge
Cambridge, UK

List of Contributors

Editor(s):
Atta-ur-Rahman FRS
Honorary Life Fellow, Kings College
University of Cambridge
UK




Contributor(s):
Charanjit Kaur
Department of Anatomy
MD10, 4 Medical Drive
Yong Loo Lin School of Medicine
National University of Singapore
Singapore


Eng-Ang Ling
Department of Anatomy
MD10, 4 Medical Drive
Yong Loo Lin School of Medicine
National University of Singapore
Singapore


Gurugirijha Rathnasamy
Department of Anatomy
MD10, 4 Medical Drive
Yong Loo Lin School of Medicine
National University of Singapore
Singapore


Jared Wilcox
Divisions of Orthopaedic Surgery and Neurosurgery
University of Toronto
Canada and the Division of Genetics and Development
Toronto Western Research Institute
Toronto
Canada


Madhuvika Murugan
Department of Anatomy
MD10, 4 Medical Drive
Yong Loo Lin School of Medicine
National University of Singapore
Singapore


Michael G. Fehlings
Divisions of Orthopaedic Surgery and Neurosurgery
University of Toronto
Canada and the Division of Genetics and Development
Toronto Western Research Institute
Toronto
Canada


Romain-Daniel Gosselin
Pain Centre, Department of Anesthesiology
University Hospital Centre (CHUV) and Department of Fundamental Neuroscience
University of Lausanne
Lausanne
Switzerland


Seungkyu Lee
F.M. Kirby Neurobiology Center
Children's Hospital Boston
Department of Neurobiology
Harvard Medical School
Boston
MA
USA


Simon Harris
Divisions of Orthopaedic Surgery and Neurosurgery
University of Toronto Canada and the Division of Genetics and Development
Toronto Western Research Institute
Toronto
Canada


Sun W. Hwang
Department of Biomedical Sciences
Korea University College of Medicine
Seoul
Korea


Yuji Odagaki
Department of Psychiatry
Faculty of Medicine
Saitama Medical University
Saitama
Japan




Advertisement


Related Journals



Related Books



Webmaster Contact: urooj@benthamscience.org Copyright © 2016 Bentham Science