Frontiers in Clinical Drug Research - Anti-Cancer Agents

Volume 1

by

Atta-ur-Rahman

DOI: 10.2174/97816080579861130101
eISBN: 978-1-60805-798-6, 2014
ISBN: 978-1-60805-799-3
ISSN: 2215-0803 (Online)



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Frontiers in Clinical Drug Research - Anti-Cancer Agents should prove to be a valuable resource for pharmaceutical sc...[view complete introduction]

Table of Contents

Preface

- Pp. i-ii (2)

Atta-ur-Rahman

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List of Contributors

- Pp. iii-iv (2)

Atta-ur-Rahman

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A New Approach to Cancer Therapy: The Tumor Microenvironment as Target

- Pp. 3-68 (66)

Reto A. Schwendener and Sibel Mete

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The Current Status of Cladribine in the Treatment of Lymphoid and Myeloid Malignancies

- Pp. 69-114 (46)

Tadeusz Robak and Pawel Robak

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The Mechanisms of Telomere and Telomerase Regulation in Hematologic Malignancies

- Pp. 115-183 (69)

Kiyotaka Kawauchi, Masaharu Akiyama and Osamu Yamada

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The Treatment of Metastatic Non-Small Cell Lung Cancer with Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitors

- Pp. 184-238 (55)

Vera Hirsh

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Targeting Key Signaling Pathways in Pediatric Brain Tumors

- Pp. 239-267 (29)

Fernanda I. Arnaldez and Katherine E. Warren

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Natural Anti-Cancer Products

- Pp. 268-338 (71)

Shao-Zhi Fu, Ling-Lin Yang and Jing-Bo Wu

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Index

- Pp. 339-358 (20)

Atta-ur-Rahman

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Preface

Frontiers in Clinical Drug Research - Anti-Cancer Agents should prove to be a valuable resource for pharmaceutical scientists and postgraduate students seeking updated and critical information for developing clinical trials and devising research plans in the field.

In chapter 1, Schwendener and Mete review the key interactions between tumor cells and surrounding mesenchymal and immune cells in the TME and discuss how they can promote tumor progression due to the interaction between tumor cells and immune cells in Tumor Microenvironment (TME). The review emphasizes the therapies targeted towards tumor-associated macrophages. Moreover, the recent developments towards therapies aiming at the cellular and molecular components of the TME are also discussed. Robak and Robak in Chapter 2 focus on recent advances in the treatment of hematologic malignancies by using a nucleoside purine analog, Cladribine (2-CdA). They summarize the current status of 2-CdA in the treatment of hematologic malignancies.

Targeting telomerase may be an attractive therapeutic approach for treating hematologic malignancies due to the association of telomere shortening and telomerase activation with the diagnosis of various hematologic tumors. In chapter 3, Kawauchi et al. review the mechanisms of telomere and telomerase regulation in hematologic malignancies with several strategies of telomerase Inhibition and other therapeutic methods. Lung cancer is one of the leading causes of the cancer death worldwide. The treatment of non-small Cell lung cancer (NSCLC) requires an individualized approach due to its heterogeneity. In chapter 4, Vera Hirsh describes the role of EGFR tyrosine kinase inhibitors (EGFRTKIs) for the treatment of non-small cell lung cancer (NSCLC) in patients with epidermal growth factor receptor (EGFR) mutations.

Pediatric tumors offer unique challenges as compared to their adult counterparts. Arnaldez and Warren in chapter 5 review the key signaling pathways implicated in their tumorigenesis and recent efforts to target them. In chapter 6, Fu et al. provide a comprehensive overview of anti-tumor natural products in drug discovery and clinical applications. This review describes the role of plant-derived natural products, animal extracts & medical anti-tumor minerals as anti-tumor natural products.

It is hoped that the readers will find these reviews valuable and thought provoking so that they trigger further research in the quest for the pharmaceutical development of anti-cancer agents.

I am grateful for the timely efforts made by the editorial personnel, especially Mr. Mahmood Alam (Director Publications) and Mr. Shehzad Naqvi (Senior Manager Publications) at Bentham Science Publishers.

Atta-ur-Rahman, FRS
Kings College
University of Cambridge
Cambridge
UK

List of Contributors

Editor(s):
Atta-ur-Rahman FRS
Kings College, University of Cambridge
Honorary Life Fellow
Cambridge
UK




Contributor(s):
Fernanda I. Arnaldez
National Institutes of Health/National Cancer Institute/Pediatric Oncology Branch
Center for Cancer Research, Building 10 CRC Room 1-3816
Bethesda
MD, 20892
USA


JingBo Wu
Department of Oncology
The Affiliated Hospital of Luzhou Medical College
Luzhou Medical College
Luzhou
China


Katherine E. Warren
National Institutes of Health/National Cancer Institute/Pediatric Oncology Branch
Center for Cancer Research, Building 10 CRC Room 1-3816
Bethesda
MD, 20892
USA


Kiyotaka Kawauchi
Tokyo Women's Medical University, Medical Center East, Department of Medicine
2-1-10 Nishiogu Arakawa-ku
Tokyo, 116-8567
Japan
/
Nishiogu Clinic, 6-15-5 Nishiogu Arakawa-ku
2-1-10 Nishiogu Arakawa-ku
Tokyo, 116-0011
Japan


LingLin Yang
Department of Oncology
The Affiliated Hospital of Luzhou Medical College
Luzhou Medical College
Luzhou,
China


Masaharu Akiyama
The Jikei University School of Medicine
Department of Pediatrics and Division of Molecular Genetics
Institute of DNA Medicine, 3-25-8 Nishishinbashi Minatoku,
Tokyo, 105-8461
Japan


Osamu Yamada
Teikyo Heisei University, Division of Human Health Care
4-21-2 Nakano, Nakano-ku
Tokyo
Japan


Pawel Robak
Department of Experimental Hematology
Medical University of Lodz
93-510 Łódź
Ciolkowskiego 2
Poland


Reto A. Schwendener
Institute of Molecular Cancer Research
University of Zurich
Zurich
Switzerland


ShaoZhi Fu
Department of Oncology
The Affiliated Hospital of Luzhou Medical College
Luzhou Medical College
Luzhou
China


Sibel Mete
Institute of Molecular Cancer Research
University of Zurich
Zurich,
Switzerland


Tadeusz Robak
Department of Hematology
Medical University of Lodz
93-510 Łódź
Ciolkowskiego 2
Poland


Vera Hirsh
Chief, Hematology-Oncology Services
Santa Cabrini Hospital

/
Associate Physician, Oncology Services
Royal Victoria Hospital and Montréal General Hospital

/
Associate Professor, Department of Oncology
Faculty of Medicine, McGill University
Montréal
Québec
Canada




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