Cutting Edge Therapies for Cancer in the 21st Century


by

Pier P. Claudio, Paraskevi Vogiatzi

DOI: 10.2174/97816080588081140101
eISBN: 978-1-60805-880-8, 2014
ISBN: 978-1-60805-881-5



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Cancer is a broad group of diseases involving unregulated cell growth with elevated death rates as more people live in old age with mass lifes...[view complete introduction]

Table of Contents

Foreword

- Pp. i

Uma Sundaram

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Preface

- Pp. ii

Pier Paolo Claudio and Paraskevi Vogiatzi

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List of Contributors

- Pp. iii-vi (4)

Pier Paolo Claudio and Paraskevi Vogiatzi

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Role of Caveolin-1 in Cancer and Therapeutic Implications

- Pp. 3-27 (25)

Gloria Bonuccelli, Philippe G. Frank and Michael P. Lisanti

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Role of Epigenetic Alterations in the Pathogenesis of Cancer: Recent Clinical Trials in Epigenetic Therapy

- Pp. 28-80 (53)

Caterina Cinti, Monia Taranta, Ilaria Naldi and Juan Carlos Trivino Pardo

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Radiation in Cancer Therapy

- Pp. 81-110 (30)

Ana L. Romero-Weaver and Candace M. Howard

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Interferons: Production, Signaling and Uses in Cancer Treatment

- Pp. 111-155 (45)

Ana L. Romero-Weaver

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Use of Energetic Charged Particles in Radiotherapy

- Pp. 156-166 (11)

Marco Durante and Daniela Trani

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Agonist and Antagonist Acting on The Leptin-Leptin Receptor Interface: Present and Future

- Pp. 167-183 (17)

Laszlo Otvos

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Jak2/Stat5a/b Signaling Axis and Novel Therapeutic Strategies in Prostate Cancer

- Pp. 184-218 (35)

Shilpa Gupta, Paraskevi Vogiatzi, David T. Hoang and Marja T. Nevalainen

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Targeting Interleukin-6 for the Treatment of Castration-Resistant Prostate Cancer

- Pp. 219-252 (34)

Sonia Godoy-Tundidor, Sucharitha Balasubramaniam, Ana Romero- Weaver and Zoran Culig

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Role of Gastrokine 1 in Gastric Cancer: A Potential Diagnostic Marker and Antitumor Drug

- Pp. 253-270 (18)

Maria Irene Scarano, Emili Rippa, Filomena Altieri, Chiara Stella Di Stadio, Giuseppina Miselli and Paolo Arcari

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Nuclear Medicine Spectrum in Neuroendocrine Tumour Management: Molecular-Based Apogee Effectuating Improved Outcomes

- Pp. 271-351 (81)

Pipitsa Valsamaki

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Using Molecular Prognostic Markers as a Basis for Designing Novel Oral Cancer Therapeutics

- Pp. 352-386 (35)

Faizan Alawi and John J. Sauk

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Cancer Therapy May be Improved if Diet Contains Omega 3 Fatty Acids

- Pp. 387-424 (38)

Johannes F. Fahrmann, Theodore R. Witte and W. Elaine Hardman

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Ultrasound Contrast Agents in Cancer Therapy

- Pp. 425-512 (88)

Rounak Nande and Pier Paolo Claudio

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Subject Index

- Pp. 513-519 (7)

Pier Paolo Claudio and Paraskevi Vogiatzi

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Foreword

It is a pleasure to introduce “Cutting Edge Therapies for Cancer in the 21st Century”. As the Vice-Dean for Clinical and Translational Research at the Joan C Edwards School of Medicine of Marshall University I have had opportunity to interact with the principal author, Dr. Pier Paolo Claudio. He is an outstanding investigator performing cutting edge translational cancer research at our cancer center. His enthusiasm for his work is infectious! The book by Dr. Claudio and his former student, Dr. Vogiatzi, has a great breadth and depth of knowledge and fully meets the needs of medical students and cancer researchers.

The book is penned by professionals highly regarded in the field and addresses complex clinical and translational research in cancer with clarity. One could feel the excitement of the authors as one reads the latest advances in Caveolin-1, Stat3/5, Interferon, Interleulin-6, Leptin, Omega-3 fatty acids, and Gastrokin-1; neuroendocrine, oral, respiratory and abdominal malignancies, and the latest therapeutic advances in radiation therapy, nuclear medicine, epigenetic modifying drugs, and the emerging concepts of theranostics (therapeutic and diagnostics combined modalities) and ultrasound-mediated gene therapy.

The study of cancer is a dynamic field both diagnostically and therapeutically and this book carefully reviews the pertinent topics. It provides a logical framework for robust learning of the on-going research and critical appraisal of recently published relevant manuscripts. I unequivocally recommend this book; it is educational, insightful, and instructive.

Uma Sundaram
Marshall University
USA



Preface

What’s the purpose of this book? In the face of the large volume of cancer literature, when so many texts flood the bookstores, why offer another one? Mainly for our greatest passion for cancer research, the motivation to learn more, and share this kind of knowledge as well.

Cancer is a broad group of diseases involving unregulated cell growth with elevated death rates since more people live in old age with mass lifestyle changes occurring in the developing world. The causes of cancer are diverse, complex, and still only partially understood. The chances of surviving the disease vary remarkably by the type and location of the malignancy and the extent of disease at the start of treatment. Early cancer detection is proving to be a valid approach. Cancer can be detected in a number of ways, including the presence of certain signs and symptoms, screening tests, or medical imaging. Cancer therapy is dynamically changing and revision and change in patient management is constant. Cancer is routinely treated with chemotherapy, radiation therapy and surgery. Tailored cancer targeted therapy is becoming an emerging objective of today.

Here, a constructive group of cancer research experts worked together with a shared vision, to give an extensive and realistic view of individual tumors, such as breast, oral, prostate, gastric, and neuroendocrine tumors. New terms and concepts in genetics and epigenetics, diet, and anticancer delivery systems are introduced aiming to present experimental strategies and key findings that enhance our understanding of cancer. It is our hope that for undergraduates, medical students, PhDs, cancer researchers, and also cancer families this text will be concise and palatable, and even conceive a curiosity about the subjects presented that will lead to further study. Material used in this book was reviewed at various stages to improve clarity and include relevant sources. A tremendous amount of work went into this text and we thank the authors for their selfless contributions.

Pier Paolo Claudio
Marshall University
USA

Paraskevi Vogiatzi
Thomas Jefferson University
USA



List of Contributors

Editor(s):
Pier P. Claudio
Marshall University
USA


Paraskevi Vogiatzi
Thomas Jefferson University
USA




Contributor(s):
Ana L. Romero-Weaver
Department of Radiation Oncology
University of Pennsylvania School of Medicine
Philadelphia
PA, 19104
USA


Candace M. Howard
Department of Biochemistry and Microbiology
McKown Translational Genomic Research Institute, Marshall University
Huntington
WV, 25755
USA


Caterina Cinti
Institute of Clinical Physiology, National Research Council
Consiglio Nazionale delle Ricerche
Siena, 53100
Italy


Chiara S. di Stadio
Department of Biochemistry and Medical Biotechnologies
University of Naples Federico I and CEINGE, Advanced Biotechnologies
Naples
Italy


Daniela Trani
Department of Radiation Oncology (MaastRO Lab/Maastro Clinic), GROW­School for Oncology and Developmental Biology
Maastricht University Medical Centre
Maastricht
MD, 6200
The Netherlands


David T. Hoang
Department of Cancer Biology, Kimmel Cancer Center
Thomas Jefferson University
Philadelphia
PA, 19107
USA


Elaine W. Hardman
Department of Biochemistry and Microbiology
McKown Translational Genomic Research Institute, Marshall University
Huntington
WV, 25755
USA


Emili Rippa
Department of Biochemistry and Medical Biotechnologies
University of Naples Federico I and CEINGE, Advanced Biotechnologies
Naples
Italy


Faizan Alawi
Department of Pathology, School of Dental Medicine
University of Pennsylvania
Philadelphia
PA, 19104
USA


Filomena Altieri
Department of Biochemistry and Medical Biotechnologies
University of Naples Federico I and CEINGE, Advanced Biotechnologies
Naples
Italy


Giuseppina Miselli
Department of Biochemistry and Medical Biotechnologies
University of Naples Federico I and CEINGE, Advanced Biotechnologies
Naples
Italy


Gloria Bonuccelli
Departments of Stem Cell Biology and Regenerative Medicine and Cancer Biology
Kimmel Cancer Center; Thomas Jefferson University
Philadelphia
PA
USA


Ilaria Naldi
Institute of Clinical Physiology
Consiglio Nazionale delle Ricerche
Siena, 53100
Italy


Johannes F. Fahrmann
Department of Biochemistry and Microbiology
McKown Translational Genomic Research Institute, Marshall University
Huntington
WV, 25755
USA


John J. Sauk
J.R. Brown Cancer Center
University of Louisville, Cancer Center
Louisville
KY, 40202
USA


Juan C. T. Pardo
Institute of Clinical Physiology
Consiglio Nazionale delle Ricerche
Siena, 53100
Italy


Laslo Otvos
PeptheRx, Inc
801 Mockingbird Lane
Audubon
PA, 19403
USA


Marco Durante
Biophysics Department
GSI Helmholtzzentrum für Schwerionenforschung
Planckstraße 1
Darmstadt, 64291
Germany


Maria I. Scarano
Department of Biochemistry and Microbiology
McKown Translational Genomic Research Institute, Marshall University
Huntington
WV, 25755
USA


Marja T. Nevalainen
Department of Cancer Biology, Kimmel Cancer Center
Thomas Jefferson University
Philadelphia
PA, 19107
USA


Michael P. Lisanti
Breakthrough Breast Cancer Research Unit
Institute of Cancer Sciences, University of Manchester
United Kingdom (UK)


Monia Taranta
Institute of Clinical Physiology
Consiglio Nazionale delle Ricerche
Siena, 53100
Italy


Paolo Arcari
Department of Biochemistry and Medical Biotechnologies
University of Naples Federico I and CEINGE, Advanced Biotechnologies
Naples
Italy


Paraskevi Vogiatzi
Department of Cancer Biology, Kimmel Cancer Center
Thomas Jefferson University
Philadelphia
PA, 19107
USA


Philippe G. Frank
Departments of Stem Cell Biology and Regenerative Medicine and Cancer Biology
Kimmel Cancer Center; Thomas Jefferson University
Philadelphia
PA
USA


Pier P. Claudio
Department of Biochemistry and Microbiology, Department of Surgery
McKown Translational Genomic Research Institute, Marshall University
Huntington
WV, 25755
USA


Pipitska Valsamaki
Nuclear Medicine Department
“Alexandra” University General Hospital
Athens
Greece


Rounak Nande
Department of Biochemistry and Microbiology
McKown Translational Genomic Research Institute, Marshall University
Huntington
WV, 25755
USA


Shilpa Gupta
Department of Medical Oncology
Thomas Jefferson University
Philadelphia
PA, 19107
USA


Sonia Godoy-Tundidor
Department of Urology
Innsbruck Medical University
Anichstrasse 35
Innsbruck, A-6020
Austria


Sucharitha Balasubramaniam
Department of Cancer Biology
Thomas Jefferson University
Philadelphia
PA, 19107
USA


Theodore R. Witte
Department of Biochemistry and Microbiology
McKown Translational Genomic Research Institute, Marshall University
Huntington
WV, 25755
USA


Zoran Culig
Department of Urology
Innsbruck Medical University
Anichstrasse 35
Innsbruck, A-6020
Austria




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