Applications of NMR Spectroscopy

Volume 2

by

Atta-ur-Rahman, M. Iqbal Choudhary

DOI: 10.2174/97816080596521150201
eISBN: 978-1-60805-965-2, 2015
ISBN: 978-1-60805-999-7
ISSN: 2405-4674 (Print)
ISSN: 2405-4682 (Online)



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Applications of NMR Spectroscopy is an eBook series devoted to publish...[view complete introduction]

Table of Contents

Preface

- Pp. i-ii (2)

Atta-ur-Rahman and M. Iqbal Choudhary

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List of Contributors

- Pp. iii-iv (2)

Atta-ur-Rahman and M. Iqbal Choudhary

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Application of NMR Spectroscopy in Plant Polyphenols Associated with Human Health

- Pp. 3-92 (90)

Ziaullah and H.P. Vasantha Rupasinghe

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MR Spectroscopy in Neuroradiology

- Pp. 93-120 (28)

Stephan Ulmer and Frank J. Ahlhelm

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Portable NMR-Based Sensors in Medical Diagnosis

- Pp. 121-146 (26)

Sing Muk Ng

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NMR Molecular Recognition Studies for the Elucidation of Protein and Nucleic Acid Structure and Function

- Pp. 147-219 (73)

Cristina Airoldi, Silvia Merlo and Erika Sironi

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Mathematical Formulations Used in Solid-State NMR for Structural Biology

- Pp. 220-241 (22)

Eugene Stephane Mananga

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Subject Index

- Pp. 242-248 (7)

Atta-ur-Rahman and M. Iqbal Choudhary

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Preface

From its early beginning in 1940s Nuclear Magnetic Resonance (NMR) spectroscopy has evolved into a diverse, powerful, and essential analytical tool with applications in numerous fields, including structural biology, pharmaceutical sciences, material sciences, medical imaging, etc. NMR spectroscopic techniques in biomarker-based disease diagnosis, quality control of food and medicines, drug discovery and development, and materials and forensic sciences. The eBook series, “Applications of NMR Spectroscopy” provides comprehensive accounts of cutting edge developments in these fields. This second volume of the series is an excellent compilation of five well written reviews, contributed by several leading experts in the relevant fields.

Plant phenolics, particularly flavonoids and isoflavonoids, are known for their anti-oxidant properties. By virtue of this, plant phenolics are capable of preventing the on-set as well as progress of various diseases such as cancers, cardiovascular disorders, pre-mature ageing and neurological diseases. NMR spectroscopy is an excellent tool for the estimation, structure elucidation, conformation analyses, and study of hydrogen bonding patterns of various classes of plant phenolics in plant extracts, as well as in prepared formulations, and other health promoting products. Ziaullah and Rupasinghe have contributed an excellent review on the applications of NMR spectroscopy in the structure elucidation of polyphenols.

Magnetic Resonance Spectroscopy (MRS) is a relatively new technique which is based on the same principles as NMR spectroscopy, except that there is no read-out gradient and the frequency information is used to identify different chemical compounds and molecular compositions of the samples. Ulmer and Ahlhelm provide an in-depth review on the MRS technique, and its clinical applications such as brain development, noxa during pregnancy, developmental delay, stroke, infections, mitochondrial disorders, as well as brain tumours and neurological disorders.

Continuing the theme of medical and biomedical applications of NMR spectroscopy, Sing Muk Ng describes the recent developments of portable NMR-based sensors, such as NMR-MOUSE for onsite monitoring. These sensors are smaller in size and cost effective for on site in situ measurements. Despite their lower resolution, such portable sensors hold great promise for the diagnosis of diseases, etc, and deserve to be further developed for wide spread applications.

Airoldi et al have contributed a comprehensive review on various NMR techniques employed to study the molecular recognition process, including target identification and validation in drug discovery and development, ligand-receptor interactions, ligand screening and optimization, and SAR (Structure-Activity Relationship) studies. Applications, and merits and demerits of several robust NMR techniques, such as STD-NMR, trNOESY, WaterLOGSY, NOE pumping, etc are extensively discussed.

Structural biology is an important field in biomedical research. NMR has served as a key technique, along with single-x-ray diffraction, to determine the structures and dynamics of complex biological molecules, including proteins. Solution state NMR spectroscopy of proteins has numerous limitations particularly because of their insoluble nature. Membrane proteins are difficult to crystallize and also difficult to solubilize. In such cases, solid state NMR spectroscopy can serve as a viable alternative to solution NMR and X-ray crystallography. Mananga presents a comprehensive review of key mathematical formulations which have been developed to calculate various structural parameters from solid state NMR data. These include key structural biology parameters such as torsion angles, dihedral angles, bond distances and angles, etc.

The authors who have contributed these excellent reviews deserve our special appreciation. We would also like to acknowledge the efficient management of the entire team of Bentham Science Publishers, especially Mr. Mahmood Alam (Director Publications) and Ms. Fariya Zulfiqar (Assistant Manager Publications).

Atta-ur-Rahman, FRS
Kings College
University of Cambridge
Cambridge
UK

&

M. Iqbal Choudhary
H.E.J. Research Institute of Chemistry
International Center for Chemical and Biological Sciences
University of Karachi
Karachi
Pakistan

List of Contributors

Editor(s):
Prof. Dr. Atta-ur-Rahman
University of Cambridge
Cambridge
UK


Prof. M. Iqbal Choudhary
H.E.J. Research Institute of Chemistry
University of Karachi
Karachi-75270
Pakistan




Contributor(s):
Cristina Airoldi
Department of Biotechnology and Biosciences
University of Milano-Bicocca
Piazza della Scienza 2
20126 Milan
Italy


Erika Sironi
Department of Biotechnology and Biosciences
University of Milano-Bicocca
Piazza della Scienza 2
20126 Milan
Italy


Eugene Stephane Mananga
Harvard University, Harvard Medical School
Massachusetts General Hospital, Center for Advanced Medical Imaging Sciences
Division of Nuclear Medicine and Molecular Imaging Physics, Department of Radiology
5 Fruit Street
Boston
Massachusetts 02114
USA


Frank J. Ahlhelm
Neuroradiology
Kantonsspital Baden
Im Ergel
5404 Baden-Dättwil
Switzerland


H.P. Vasantha Rupasinghe
Department of Environmental Sciences, Faculty of Agriculture
Dalhousie University
Truro, P.O. Box 550
Nova Scotia B2N 5E3
Canada


Silvia Merlo
Department of Biotechnology and Biosciences
University of Milano-Bicocca
Piazza della Scienza 2
20126 Milan
Italy


Sing Muk Ng
Faculty of Engineering, Computing, and Science
Swinburne University of Technology Sarawak Campus
Jalan Simpang Tiga
Kuching
Sarawak, 93350
Malaysia
/
Swinburne Sarawak Research Centre for Sustainability Technologies
Swinburne University of Technology Sarawak Campus
Jalan Simpang Tiga
Kuching
Sarawak, 93350
Malaysia


Stephan Ulmer
Neuroradiology
Medical Radiological Institute (MRI)
Bahnhofplatz 3
8001 Zurich
Switzerland
/
Institute of Neuroradiology , Department of Radiology and Neuroradiology
University Hospital Schleswig-Holstein
Schittenhelmstrasse 10
24105 Kiel
Germany


Ziaullah
Department of Environmental Sciences
Faculty of Agriculture, Dalhousie University
Truro, P.O. Box 550
Nova Scotia B2N 5E3
Canada




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