Frontiers in Cardiovascular Drug Discovery

Volume 2

by

Atta-ur-Rahman , M. Iqbal Choudhary

DOI: 10.2174/97816080596831150201
eISBN: 978-1-60805-968-3, 2015
ISBN: 978-1-60805-969-0
ISSN: 2452-3267 (Print)
ISSN: 1879-6648 (Online)



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Indexed in: Book Citation Index, EMBASE, Chemical Abstracts.

Frontiers in Cardiovascular Drug Discovery is an eBook series devoted to publis...[view complete introduction]

Table of Contents

Foreword

- Pp. i

Carl J. Lavie

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Preface

- Pp. ii-iii (2)

Atta ur-Rahman and M. Iqbal Choudhary

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List of Contributors

- Pp. iii-iv (2)

Atta ur-Rahman and M. Iqbal Choudhary

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Nature Products and Cardiovascular Disorders

- Pp. 3-91 (89)

Dingguo Zhang, Liansheng Wang and Zhijian Yang

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Development of Direct Anti-Atherosclerosis Drugs on the Basis of Natural Products

- Pp. 92-133 (42)

Alexander N. Orekhov, Alexandra A. Melnichenko and Yuri V. Bobryshev

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Novel Oral Anticoagulants for Thromboprophylaxis in Non- Valvular Atrial Fibrillation: Focus on Randomized Clinical Trials

- Pp. 134-230 (97)

Tatjana S. Potpara, Marija M. Polovina, Marina M. Licina, Milica S. Prostran and Gregory Y.H. Lip

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Clinical Value of Catheter-Based Sympathetic Nerve Modulation

- Pp. 231-248 (18)

A. Doltra, E. Fleck and S. Kelle

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Subject Index

- Pp. 249-256 (8)

Atta ur-Rahman and M. Iqbal Choudhary

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Foreword

Cardiovascular disease (CVD) remains the major threat to health throughout the Westernized World. Although tremendous advances have been made during recent decades in the prevention and treatment of CVD, still CVD, including heart disease (coronary heart disease/CHD, hypertension/HTN, heart failure, and atrial fibrillation/AF) and stroke combine to cause more morbidity and mortality than cancer and any other diseases. Therefore, the prevention and treatment of CVD remains a major emphasis to clinicians, scientists, and the lay public.

Professor Dr. ATTA-UR-RAHMAN and Prof. Dr. IQBAL CHOUDHARY have contributed substantially during recent decades on many important topics related with health and CVD, particularly in the fields of natural products and bio-organic chemistry. In this new book, Volume 2 Frontiers in Cardiovascular Drug Discovery, they, along with the authors and co-authors of the chapters, provide substantial new and innovative information for the potential of natural substances (Traditional Chinese medicine, herbs, dietary nutitional substances, vitamins, tea, omega-3 fatty acids or fish oils, garlic, coenzyme Q 10, etc.) to protect against and to treat CVD, including the potential to prevent and treat atherosclerosis and CHD, the true # 1 killer in the Westernized World. There are also very detailed and comprehensive discussions of the vitamin K antagonists and the new alternatives to this therapy to prevent thromboembolic events, especially stroke, in non-valvular AF, which has been increasing in epidemic proportions in much of modern society. There is also a very interesting discussion of sympathetic nerve modulation as a potential alternative to pharmacological treatment that could become applicable to the treatment of millions of patients with HTN.

This book adds admirably to the large collection of work that these authors have provided, and this book should be of substantial interest to the clinical and scientific readership, particularly those interested in natural and innovative efforts for the prevention and treatment of CVD. I highly recommend reading this very interesting piece of work!

Carl J. Lavie
John Ochsner Heart and Vascular Institute
Professor of Medicine
Ochsner Clinical School-UQ School of Medicine
USA


Preface

Cardiovascular diseases are the leading cause of morbidity and mortality worldwide. Atherosclerosis, hypertension, diabetes, obesity and age-related physiological and morphological changes, along with diet, stress, alcohol consumption and smoking are among the most important risk factors of cardiovascular diseases. Despite major developments in the prevention and management of cardiovascular diseases, over 20% of all global deaths are attributed to cardiovascular diseases as existing treatments are far from ideal. The recently established link between low-grade inflammation, due to atherosclerosis, obesity and infection, has led to the identification of several new targets for drug discovery and development. In brief the need of both effective treatment and prevention strategies, as well as a better understanding of risks and progress of disease at the molecular level, is greatly felt.

Volume 2 of the book series “Frontiers in Cardiovascular Drug Discovery” is a compilation of four excellent reviews, contributed by established researchers in the field.

Dingguo et al. have reviewed the cardioprotective effects of medicinal herbs used in traditional Chinese medicines, along with dietary nutritional supplements, and other natural products.

The second review, contributed by Alexander et al., also focuses on natural products. It discusses the results of studies of various agents on atherosclerosis is highlighted. The importance of natural products as primary preventive therapy for atherosclerosis. These natural products were found to be as effective as conventional drugs used in the regression of carotid atherosclerosis, and are more appropriate in the long term treatment of vascular disorders. The discovery of natural compounds as anti-atherosclerotic agents with limited side effects may lead to a novel therapeutic strategy against atherosclerosis prophylaxis.

Tatjana et al. present a brief summary of key findings achieved with new oral anticoagulants, including thrombin and factor Xa inhibitors, for the prevention of stroke in arterial fibrillation. These oral anticoagulants are superior to existing oral vitamin K antagonists in terms of rapid action, dose-related anticoagulant effect, lower drug-drug interactions, and do not need regular laboratory monitoring. Furthermore, these novel oral anticoagulants have exhibited remarkable efficacy in various phase III randomized trials.

Modulation of the sympathetic nervous system plays an important role in hypertension. In the last chapter by Doltra et al., the authors have discussed the results of animal studies and clinical trials on radiofrequency based sympathetic nerve modulation. Pathophysiological and technical aspects of this emerging treatment is discussed in this review.

We expect that this excellent compilation of well written scientific articles will contribute in updating the knowledge of researchers in academic and R&D institutions working in this important field. We wish to thank the contributing authors for presenting exciting state-of-the-art accounts in this field, and for providing a critical analysis of various new treatments and prevention regimen commentaries. We also profoundly appreciate the efforts and skills of the editorial staff, particularly Mr. Mahmood Alam (Director Publication) and Ms. Sara Yaser (Manager Publications), for bringing the second volume in a timely and most efficient manner.

Prof. Atta-ur-Rahman, FRS
Kings College
University of Cambridge
Cambridge
UK

Prof. M. Iqbal Choudhary
H.E.J. Research Institute of Chemistry
International Center for Chemical and Biological Sciences
University of Karachi
Karachi
Pakistan


List of Contributors

Editor(s):
FRS Atta-ur-Rahman
University of Cambridge
Kings College
Cambridge
UK


M. Iqbal Choudhary
Biological Sciences
H.E.J. Research Institute of Chemistry
University of Karachi
Karachi, 75270
Pakistan




Contributor(s):
A. Doltra
Deutsches Herzzentrum Berlin, Department of Internal Medicine/Cardiology
Berlin
Germany


Alexander N. Orekhov
Institute for Atherosclerosis Research, Skolkovo Innovative Center
Moscow
Russia
/
Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences
Moscow
Russia


Alexandra A. Melnichenko
Institute for Atherosclerosis Research, Skolkovo Innovative Center
Moscow
Russia
/
Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences
Moscow
Russia


Dingguo Zhang
Department of Cardiology
the First Affiliated Hospital of Nanjing Medical University
Nanjing
China


E. Fleck
Deutsches Herzzentrum Berlin, Department of Internal Medicine/Cardiology
Berlin
Germany


Gregory Y.H. Lip
Centre for Cardiovascular Sciences, City Hospital
University of Birmingham
Birmingham B18 7QH,
UK


Liansheng Wang
Department of Cardiology
the First Affiliated Hospital of Nanjing Medical University
Nanjing
China


Marija M. Polovina
Cardiology Clinic
Clinical Center of Serbia
Belgrade
Serbia


Marina M. Licina
Cardiology Clinic
Clinical Center of Serbia
Belgrade
Serbia


Milica S. Prostran
Department of Pharmacology, Clinical Pharmacology and Toxicology
Faculty of Medicine, University of Belgrade
11000 Belgrade
Serbia


S. Kelle
Deutsches Herzzentrum Berlin, Department of Internal Medicine/Cardiology
Berlin
Germany


Tatjana S. Potpara
Faculty of Medicine, University of Belgrade
Serbia
/
Cardiology Clinic, Clinical Center of Serbia
Belgrade
Serbia


Yuri V. Bobryshev
Moscow
Russia
/
Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences
Moscow
Russia
/
Faculty of Medicine, School of Medical Sciences, University of New South Wales
Sydney
Australia
/
N. P. Ogaryov Mordovian State University, Biological Faculty
Saransk, Republic of Mordovia
Russia


Zhijian Yang
Department of Cardiology
the First Affiliated Hospital of Nanjing Medical University
Nanjing
China




Reviews

“…integrates traditional medicine with the latest concepts in cardiovascular drug discovery and Treatment… …will be of immense utility to researchers in the field of cardiovascular research.” - Priyadarshini Raman, Asian Journal of Pharmacology and Toxicology, Volume 3, No. 7, March 2015 – Literati Publishers.


“ …provides an important advance in our knowledge of cardiovascular therapeutics.” – Dr. Ambuj Roy MD., DM, Additional Professor of Cardiology, All India Institute of Medical Sciences, Asian Cardiovascular and Thoracic Annals Volume, 23, Issue 6, July 2015 – SAGE Publications

http://aan.sagepub.com/content/23/6/758.full


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