Frontiers in Medicinal Chemistry

Volume 7

by

Atta-ur-Rahman , M. Iqbal Choudhary , Jizhou Wang, Allen B. Reitz

DOI: 10.2174/97816080597061150701
eISBN: 978-1-60805-970-6, 2015
ISBN: 978-1-60805-971-3
ISSN: 1567-2042 (Print)
ISSN: 1875-5763 (Online)



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Indexed in: Book Citation Index, Science (BKCI-S), Web of Science, BIOSIS Previews, EMBASE, Chemical Abstracts

“Frontiers in Medicinal Chemistry” is an Ebook series devoted to the review of ...[view complete introduction]

Table of Contents

Preface

- Pp. i

Atta-ur-Rahman, Allen B. Reitz, Iqbal Choudhary and Jizhou Wang

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List of Contributors

- Pp. ii-iv (3)

Atta-ur-Rahman, Allen B. Reitz, Iqbal Choudhary and Jizhou Wang

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Antioxidants and Neuroprotection in the Brain and Retina

- Pp. 3-33 (31)

Charanjit Kaur, Gurugirijha Rathnasamy and Eng-Ang Ling

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Acetylcholinesterase Inhibitors as Disease-Modifying Therapies for Alzheimer’s Disease

- Pp. 34-86 (53)

Diego Muñoz-Torrero

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Dopamine Receptor Agonists for Protection and Repair in Parkinson's Disease: An Update

- Pp. 87-106 (20)

Giulia Ferrari-Toninelli, Sara A. Bonini, Paola Bettinsoli, Giuseppina Maccarinelli, Giovanna Cenini, Mariagrazia Grilli, Daniela Uberti and Maurizio Memo

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The Role of Oxytocin in Neuropsychiatric Disorders

- Pp. 107-133 (27)

Donatella Marazziti, Valentina Falaschi, Stefano Baroni, Mario Catena Dell’Osso and Liliana Dell’Osso

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Structural and Computational Insights into Conformational Diseases: A Review

- Pp. 134-182 (49)

Xavier Fernàndez-Busquets, Natalia S. de Groot and Salvador Ventura

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Cholinesterase Inhibitors Useful for the Treatment of Neurodegenerative Disorders from Natural Sources: Past and Present

- Pp. 183-227 (45)

Monica R. Loizzo, Rosa Tundis, Federica Menichini and Francesco Menichini

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PfDHFR Enzyme Inhibitors: Rational Design Using Pharmacoinformatic Tools

- Pp. 228-273 (46)

Sheenu Abbat, Shweta Bhagat and Prasad V. Bharatam

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Bacterial Protein Toxins: Current and Potential Clinical Use

- Pp. 274-312 (39)

Alessia Fabbri, Francesca Rosadi, Giulia Ballan, Antonella Del Brocco, Sara Travaglione, Stefano Loizzo and Carla Fiorentini

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Vaccines against Cysticercosis: A Revisited Review Focusing on Taenia solium

- Pp. 313-335 (23)

Edda Sciutto, Gladis Fragoso, Marisela Hernández, Gabriela Rosas, Carlos Larralde and Sergio Rosales-Mendoza

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Therapeutic Approaches to Liver Fibrosis

- Pp. 336-384 (49)

Enrico Maria Zardi

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Biologically Active Chitosan Systems for Regenerative Engineering

- Pp. 385-414 (30)

Tao Jiang, Sangamesh G. Kumbar, Lakshmi S. Nair and Cato T. Laurencin

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Subject Index

- Pp. 415-422 (8)

Atta-ur-Rahman, Allen B. Reitz, Iqbal Choudhary and Jizhou Wang

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Preface

This current Volume 7 of Frontiers in Medicinal Chemistry is comprised of 11 chapters written by the appropriate experts in their fields of study, focusing on topics of high important in the fields of medicinal chemistry, early-stage drug discovery, target validation, and chemical biology.

The first six manuscripts are focused on topics of interest to diseases of the central nervous system. The first by Kaur et al. is on antioxidants and neuroprotection, the second by Munoz-Torrero is on acetylcholinesterase inhibitors for Alzheimer’s disease, the third by Ferrari-Toninelli et al. covers dopamine agonists for Parkinson’s disease, the fourth by Marassiti et al. highlights the role of oxytocin in psychiatry, the fifth by Fernandez-Busquets et al. pertains to the many proteins for which inappropriate conformation contributes to pathology such as Alzheimer’s, and the sixth by Loizzo et al. covers natural-product based cholinesterase inhibitors, also for Alzheimer’s disease. The next three reviews are in the area of infectious disease research, the first by Abbat et al. on enzyme inhibitors for the treatment of malaria, the second by Fabbri et al. on bacterial protein toxins, and the third by Sciutto et al. on a vaccine approach to cysticercosis. The next review is on liver fibrosis by Zardi, and the final chapter is by Jiang et al. on regenerative engineering.

Thanks are given to the staff of Bentham Science Publishers for their support and guidance, particularly Drs. Mahmood Alam and Matthew Honan.

Allen B. Reitz
Fox Chase Chemical Diversity Center, Inc.
Doylestown, PA 18902
USA


Atta-ur-Rahman, FRS
Kings College
University of Cambridge
Cambridge
UK


Iqbal Choudhary
H.E.J. Research Institute of Chemistry
University of Karachi, Karachi 75270
Pakistan


&

Jizhou Wang
Silver Spring, MD,USA
USA


List of Contributors

Editor(s):
Atta-ur-Rahman
Kings College
University of Cambridge
Cambridge
UK


M. Iqbal Choudhary
H.E.J. Research Institute of Chemistry
University of Karachi
Karachi-75270
Pakistan


Jizhou Wang
Head Chemist
Influmedix Inc
170 N Radnor Chester Rd
Radnor, PA 19403
USA


Allen B. Reitz
Chief Executive Officer
Fox Chase Chemical Diversity Center, Inc. Pennsylvania Biotechnology Center
3805 Old Easton Road
Doylestown, PA 18902
USA




Contributor(s):
Alessia Fabbri
Department of Therapeutic Research and Medicines Evaluation
Istituto Superiore di Sanità
Viale Regina Elena
299.00161 Roma Italy


Antonella Del Brocco
Department of Therapeutic Research and Medicines Evaluation
Istituto Superiore di Sanità
Viale Regina Elena
299.00161 Roma Italy


Carla Fiorentini
Department of Therapeutic Research and Medicines Evaluation
Istituto Superiore di Sanità
Viale Regina Elena
299.00161 Roma Italy


Carlos Larralde
Instituto de Investigaciones Biomédicas
UNAM
Mexico


Cato T. Laurencin
The Raymond and Beverly Sackler Center for Biomedical, Biological, Physical and Engineering Sciences
University of Connecticut Health Center
CT 06030
Farmington
USA


Charanjit Kaur
Department of Anatomy
Yong Loo Lin School of Medicine
Blk MD10, 4 Medical Drive, National University of Singapore
Singapore 117597



Daniela Uberti
Laboratori de Química Farmacèutica (Unitat Associada al CSIC),Facultat de Farmàcia
Institut de Biomedicina (IBUB), Universitat de Barcelona
Novara
Italy


Diego Muñoz-Torrero
Laboratori de Química Farmacèutica (Unitat Associada al CSIC). Facultat de Farmàcia
Institut de Biomedicina (IBUB), Universitat de Barcelona
Av. Joan XXIII 27-31
E-08028-Barcelona
Spain


Donatella Marazziti
Dipartimento di Medicina Clinica e Sperimentale, Section of Psychiatry
University of Pisa
Pisa
Italy


Edda Sciutto
Instituto de Investigaciones Biomédicas
UNAM
Mexico


Eng-Ang Ling
Department of Anatomy, Yong Loo Lin School of Medicine
Blk MD10, 4 Medical Drive, National University of Singapore
Singapore 117597


Enrico Maria Zardi
Department of Clinical Medicine
University Campus Bio-Medico
Rome
Italy


Federica Menichini
AIFA Agenzia Italiana Del Farmaco
via del Tritone 181
00187 Roma
Italy


Francesca Rosadi
Department of Therapeutic Research and Medicines Evaluation
Istituto Superiore di Sanità
Viale Regina Elena
299.00161 Roma
Italy


Francesco Menichini
Department of Pharmacy Health and Nutritional Sciences
University of Calabria
I-87036 Rende (CS)
Italy


Gabriela Rosas
Facultad de Medicina
Universidad Autónoma del Estado de Morelos
Cuernavaca
Morelos
México


Giovanna Cenini
Department of Pharmaceutical Sciences
University of Piemonte Orientale "A Avogadro"
Novara
Italy


Giulia Ballan
Department of Therapeutic Research and Medicines Evaluation
Istituto Superiore di Sanità
Viale Regina Elena
299.00161 Roma
Italy


Giulia Ferrari-Toninelli
Department of Pharmaceutical Sciences
University of Piemonte Orientale "A Avogadro"
Novara
Italy


Giuseppina Maccarinelli
Department of Pharmaceutical Sciences
University of Piemonte Orientale "A Avogadro"
Novara
Italy


Gladis Fragoso
Instituto de Investigaciones Biomédicas
UNAM
Mexico


Gurugirijha Rathnasamy
Department of Anatomy
Yong Loo Lin School of Medicine
Blk MD10, 4 Medical Drive, National University of Singapore
Singapore 117597


Lakshmi S. Nair
The Raymond and Beverly Sackler Center for Biomedical, Biological, Physical and Engineering Sciences
University of Connecticut Health Center
Farmington
CT 06030
USA


Liliana Dell’Osso
Dipartimento di Medicina Clinica e Sperimentale
Section of Psychiatry, University of Pisa
Pisa
Italy


Mariagrazia Grilli
Department of Molecular and Translational Medicine
University of Brescia
Brescia
Italy


Mario Catena Dell’Osso
Dipartimento di Medicina Clinica e Sperimentale
Section of Psychiatry, University of Pisa
Pisa
Italy


Marisela Hernández
Instituto de Investigaciones Biomédicas
UNAM
Mexico


Maurizio Memo
Department of Molecular and Translational Medicine
University of Brescia
Brescia
Italy


Monica R. Loizzo
Department of Pharmacy Health and Nutritional Sciences
University of Calabria
I-87036 Rende (CS)
Italy


Natalia S. de Groot
Medical Research Council Laboratory of Molecular Biology
Francis Crick Avenue
Cambridge
CB2 0QH United Kingdom


Paola Bettinsoli
Department of Pharmaceutical Sciences
University of Piemonte Orientale "A Avogadro"
Novara
Italy


Prasad V. Bharatam
Department of Medicinal Chemistry
National Institute of Pharmaceutical Education and Research (NIPER)
Punjab
India


Rosa Tundis
Department of Pharmacy Health and Nutritional Sciences
University of Calabria
I-87036 Rende (CS)
Italy


Salvador Ventura
Institut de Biotecnologia i Biomedicina
Universitat Autònoma de Barcelona
E-08193 Bellaterra
Spain


Sangamesh G. Kumbar
The Raymond and Beverly Sackler Center for Biomedical, Biological, Physical and Engineering Sciences
University of Connecticut Health Center
Farmington
CT 06030
USA


Sara A. Bonini
Department of Pharmaceutical Sciences
University of Piemonte Orientale "A Avogadro"
Novara
Italy


Sara Travaglione
Department of Therapeutic Research and Medicines Evaluation
Istituto Superiore di Sanità
Viale Regina Elena
299.00161 Roma Italy


Sergio Rosales-Mendoza
Laboratorio de Biofarmacéuticos Recombinantes, Facultad de Ciencias Químicas
Universidad Autónoma de San Luis Potosí
México



Sheenu Abbat
Department of Pharmacoinformatics
National Institute of Pharmaceutical Education and Research (NIPER)
S.A.S. Nagar
Punjab
India


Shweta Bhagat
Department of Medicinal Chemistry
National Institute of Pharmaceutical Education and Research (NIPER)
Punjab
India


Stefano Baroni
Dipartimento di Medicina Clinica e Sperimentale
Section of Psychiatry, University of Pisa
Pisa
Italy


Stefano Loizzo
Department of Therapeutic Research and Medicines Evaluation
Istituto Superiore di Sanità
Viale Regina Elena
299.00161 Roma Italy


Tao Jiang
The Raymond and Beverly Sackler Center for Biomedical, Biological, Physical and Engineering Sciences
University of Connecticut Health Center
Farmington
CT 06030
USA


Valentina Falaschi
Dipartimento di Medicina Clinica e Sperimentale, Section of Psychiatry
University of Pisa
Pisa
Italy


Xavier Fernàndez-Busquets
1Nanomalaria Group
Institute for Bioengineering of Catalonia (IBEC)
Baldiri Reixac 10-12
ES-08028 Barcelona
Spain




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