Young Perspectives for Old Diseases


by

Glaucia Noeli Maroso Hajj

DOI: 10.2174/97816080599281150101
eISBN: 978-1-60805-992-8, 2015
ISBN: 978-1-68108-003-1



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In this book, a great team of young neuroscientists describes the current understanding of common and rare neurodegenerative diseases, focusing o...[view complete introduction]
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Table of Contents

Foreword

- Pp. i

Rafael Linden

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Preface

- Pp. iii

Glaucia Noeli Maroso Hajj and Carolina Rezával

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List of Contributors

- Pp. v-ix (5)

Glaucia Noeli Maroso Hajj and Carolina Rezával

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The Role of Molecular and Cellular Biology in Neurodegenerative Diseases - Learning from Cancer Therapies

- Pp. 3-21 (19)

Kil Sun Lee

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Current Pharmacological and Non-Pharmacological Therapies for Neurodegenerative Diseases

- Pp. 23-48 (26)

Walter A. S. Moraes

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“The Greatness of the Smallest Ones”: The Most Valuable Attributes of Flies and Worms for the Study of Neurodegeneration

- Pp. 49-84 (36)

Carolina Rezával

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Calcium in Homeostasis and Neurodegeneration

- Pp. 85-101 (17)

Flavio H. Beraldo and Ashbell Roy

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Protein Misfolding and Propagation in Neurodegenerative Diseases

- Pp. 103-118 (16)

Tiago Góss dos Santos

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Mitochondrial Dysfunction and Free Radicals in Neuronal Death

- Pp. 119-132 (14)

Célia Harumi Tengan and Gabriela Silva Rodrigues

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Alzheimer’s Disease

- Pp. 133-154 (22)

Sofia Jurgensen and Helena Decker

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Parkinson’s Disease: Genetics, Mechanisms and Diagnosis

- Pp. 155-176 (22)

Telma Tiemi Schwindt, Enéas Galdini Ferrazoli and Henning Ulrich

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Huntington’s Disease: A Puzzle from Childhood to Senescence

- Pp. 177-203 (27)

Fabiola M. Ribeiro, Roenick P. Olmo and Tomas Dobransky

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Amyotrophic Lateral Sclerosis: A Role for Non-Neuronal Cells

- Pp. 205-222 (18)

Ana G. Barbeito

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Multiple Sclerosis: An Overview

- Pp. 223-250 (28)

Felipe von Glehn, Carlos Otávio Brandão, Alessandro S. Farias and Leonilda M. B. Santos

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Lewy Body Dementia and Frontotemporal Dementia

- Pp. 251-267 (17)

Renan Pedra Souza and Bruno Rezende Souza

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Charcot-Marie-Tooth Disease and Other Peripheral Neuropathies

- Pp. 269-325 (57)

Veronick Benoy, Constantin d`Ydewalle and Ludo Van Den Bosch

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Targeting Molecular Mechanisms of Cognitive Dysfunction

- Pp. 327-340 (14)

Rafael Roesler, Arethuza S. Dornelles and Fernando Benetti

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Stem Cell Applications for Neurodegenerative Diseases

- Pp. 341-362 (22)

Marilene Hohmuth Lopes and Lilian Cruz

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Subject Index

- Pp. 363-370 (8)

Glaucia Noeli Maroso Hajj and Carolina Rezával

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Foreword

Human neurodegenerative diseases rank amongst the most pressing subjects of modern Biomedical Science. Despite years of abundant investment, and a large body of knowledge generated by many top laboratories worldwide, little advance has been made towards the cure of diseases such as, for example, Alzheimer’s, Parkinson’s or ALS.

Experienced investigators have now battled for decades to find new leads to effective treatments. Legions of young students have joined their teams. Over the years, the latter have started independent work, building upon both existing knowledge as well as their unbiased views of both the pathogenesis and possible new therapeutic targets.

In his delightful book Advice to a young scientist, Sir Peter Medawar pointed out that ‘The old-fashioned remedy for hubris was a smart blow on the head with an inflated pig's bladder — and this is in the spirit of the rebuke that may have to be administered before the young scientist injures himself in the opinions of those who would otherwise like him and wish him well’. Such warning notwithstanding, it is equally wise to listen to what young scientists have to say. Not only many of them are perfectly aware of their standings, but also free of the partisanship we, scientists, tend to accumulate as our careers progress.

The seventeen young scientists who wrote this book got their Ph.D. degreees less than twenty, and eleven of them less than ten years ago. They are building their careers upon significant contributions to the literature on neurodegeneration. Both through my own personal collaboration with some of them, as well as by reading their chapters, I believe they should be exempt from the Medawar remedy. It is worth looking into their personal perspectives on subjects that range from basic cellular and molecular mechanisms to novel therapeutic targets and strategies to cope with neurodegenerative disease. Both young and old scientists have much to gain.

Rafael Linden, M.D., Ph.D.
Laboratory of Neurogenesis
Institute of Biophysics
Federal University of Rio de Janeiro
Brazil


Preface

Human neurodegenerative disorders produce devastating symptoms that enormously affect both patients and their relatives. The disease pathologies share specific features, such as late onset, accumulation of misfolded proteins that form aggregates in the brain and progressive degeneration of specific neuronal populations. Patients may suffer from behavioral and physical disorders, as well as severe cognitive impairments. The incidence of neurodegenerative diseases has dramatically increased with the aging of the population and although neurodegenerative diseases represent a major threat for public health, few effective treatments are currently available. In order to discover drugs to prevent and treat neurodegenerative diseases, it is imperative to decipher the genetic and molecular mechanisms that underlie the onset and development of these disorders. Despite many years of research, scientists have not yet succeeded in understanding the precise mechanisms that lead to neurodegeneration. A number of important questions remain to be answered: how do disease-associated proteins cause neuronal dysfunction and death; what underlies cell type-specific degeneration; are these diseases age-dependent; are these gender-specific; are there common pathogenic mechanisms that underlie different neurodegenerative disorders; and how can these diseases be prevented and treated? In this book we will review the most recent findings on scientific research that explored mechanisms and pathways for the diseases. We further explore how the current knowledge is being applied to improve the life of neurodegenerative disease patients.

Glaucia Noeli Maroso Hajj
International Research Center
AC Camargo Cancer Center
National Institute for Translational
Neuroscience and National
Institute of Oncogenomics (CNPq/MCT/FAPESP)
São Paulo
Brazil

Carolina Rezával
Department of Physiology
Anatomy and Genetics
University of Oxford
UK

List of Contributors

Editor(s):
Glaucia Noeli Maroso Hajj




Contributor(s):
Alessandro dos Santos Farias
Neuroimmunology Unit, Departamento de Genética
Evolução e Bioagentes, UNICAMP
Rua Monteiro Lobato, 255, Campinas
SP Brazil, CEP 13083-970
Brazil


Ana Gabriela Barbeito
Institut Pasteur de Montevideo, Laboratorio de Neurodegeneración , Mataojo 2020
Montevideo 11400
Uruguay


Arethuza da Silva Dornelles
Laboratory of Neuropharmacology and Neural Tumor Biology, Department of Pharmacology
Institute for Basic Health Sciences, and Cancer Research Laboratory, University Hospital Research Center (CPE, HCPA)
Federal University of Rio Grande do Sul. Rua Sarmento Leite
500 (ICBS, Campus Centro/UFRGS), 90050-170 Porto Alegre
RS
Brazil


Ashbeel Roy
Department of Physiology and Pharmacology
University of Western Ontario, Robarts Research Institute
London, Ontario, Canada
1151 Richmond St. N, N6A 5B7



Bruno Rezende Souza
Departamento de Fisiologia e Biofísica
Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais
Belo Horizonte
Brazil


Carlos Octávio Brandão
Neuroimmunology Unit, Dept of Genetics, Evolution and Bioagents; Dept of Neurology
University of Campinas (UNICAMP), Campinas
Rua Monteiro Lobato, 255, Campinas, SP Brazil, CEP 13083-970, Brazil
SP
Brazil


Carolina Rezával
Department of Physiology, Anatomy and Genetics
University of Oxford
Parks Road, OX1 3PT
Oxford
UK


Célia Harumi Tengan
Department of Neurology and Neurosurgery, Escola Paulista de Medicina
Universidade Federal de São Paulo
R. Pedro de Toledo, 781
São Paulo 04039-032
Brazil


Constantin d’Ydewalle
Laboratory of Neurobiology, Vesalius Research Center, VIB
Experimental Neurology (Department of Neurosciences) and Leuven research
Institute for Neuroscience and Disease (LIND), University of Leuven (KU Leuven)
Campus Gasthuisberg O&N4, box 912, Herestraat 49, B
3000 Leuven
Belgium


Enéas Galdini Ferrazoli
Departament of Physiology
Federal University of Sao Paulo
Av. Prof. Lineu Prestes , 748, Butantã, São Paulo
SP, 05508-000
Brazil


Fabíola Mara Ribeiro
Departamento de Bioquímica e Imunologia, ICB
Universidade Federal de Minas Gerais
Ave. Antonio Carlos 6627, Belo Horizonte
MG
Brazil


Felipe von Glehn
Neuroimmunology Unit, Dept of Genetics, Evolution and Bioagents; Dept of Neurology
University of Campinas (UNICAMP), Campinas, SP, Brazil
Rua Monteiro Lobato, 255, Campinas
SP
Brazil


Fernando Benetti
Department of Physiology
Institute for Basic Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil
Rua Sarmento Leite, 500 (ICBS, Campus Centro/UFRGS), 90050-170 Porto Alegre
RS
Brazil


Flávio Henrique Beraldo
Robarts Research Institute, Department of Physiology and Pharmacology
Western University
London, Ontario, Canada, 1151 Richmond St. N, N6A 5B7



Gabriela Silva Rodrigues
Department of Neurology and Neurosurgery, Escola Paulista de Medicina
Universidade Federal de São Paulo
R. Pedro de Toledo, 781
São Paulo 04039-032
Brazil


Glaucia Noeli Maroso Hajj
AC Camargo Cancer Center
International Research Center
Rua Taguá 440, Liberdade
São Paulo
Brazil


Helena Decker
The Jungers Center for Neurosciences Research
Oregon Health and Science University
OR 97239
Portland
USA


Henning Ulrich
Departamento de Bioquímica
Instituto de Química, Universidade de São Paulo
São Paulo
Brazil


Kil Sun Lee
Department of Biochemistry
Federal University of São Paulo
São Paulo
Brazil


Leonilda Maria Barbosa dos Santos
Neuroimmunology Unit, Departamento de Genética
Evolução e Bioagentes
UNICAMP, Rua Monteiro Lobato 255, Campinas
SP
Brazil


Lilian Cruz
Institute of Biomedical Sciences University of Sao Paulo, Brazil
Av. Prof. Lineu Prestes, 1524, room 428
Sao Paulo, 05508-900
Brazil


Ludo Van Den Bosch
Laboratory of Neurobiology, Vesalius Research Center, VIB
Experimental Neurology (Department of Neurosciences) and Leuven research Institute for Neuroscience and Disease (LIND)
University of Leuven (KU Leuven). Campus Gasthuisberg O&N4, box 912, Herestraat 49, B
3000 Leuven
Belgium


Marilene Hohmuth Lopes
Institute of Biomedical Sciences, University of Sao Paulo, Brazil
Av. Prof. Lineu Prestes, 1524, room 428
Sao Paulo, 05508-900
Brazil


Rafael Roesler
Laboratory of Neuropharmacology and Neural Tumor Biology, Department of Pharmacology
Institute for Basic Health Sciences, and Cancer Research Laboratory, University Hospital Research Center (CPE, HCPA)
Federal University of Rio Grande do Sul
Rua Sarmento Leite, 500 (ICBS, Campus Centro/UFRGS)
90050-170 Porto Alegre
RS
Brazil


Renan Pedra Souza
Departamento de Biologia Geral
Instituto de Ciências Biológicas
Universidade Federal de Minas Gerais
Belo Horizonte
Brazil



Roenick Proveti Olmo
Departamento de Bioquímica e Imunologia, ICB
Universidade Federal de Minas Gerais
Ave. Antonio Carlos 6627, Belo Horizonte, CEP: 31270-901
MG
Brazil


Sofia Jurgensen
Dominick P. Purpura Department of Neuroscience
Albert Einstein College of Medicine
1410 Pelham Pkwy S., Rose F. Kennedy Bldg. room 703
Bronx
NY
USA


Telma Tiemi Schwindt
Instituto de Ciências Biomédicas
Universidade de São Paulo, SP
Av. Prof. Lineu Prestes, 1524, Butantã
São Paulo
SP, 05508-900
Brazil


Tiago Góss Santos
A. C. Camargo Cancer Center
International Research Center
Rua Tagua 440
São Paulo 01508-010
Brazil


Tomas Dobransky
2DB Biotech
Kosice
Slovakia


Veronick Benoy
Laboratory of Neurobiology, Vesalius Research Center, VIB
Experimental Neurology (Department of Neurosciences
Leuven research Institute for Neuroscience and Disease (LIND), University of Leuven (KU Leuven)
Campus Gasthuisberg O&N4, box 912, Herestraat 49, B
3000 Leuven
Belgium


Walter André dos Santos Moraes
UNIFESP
Manuel de Paiva Street
313 Sao Paulo
Brazil




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