Frontiers in Stem Cell and Regenerative Medicine Research

Volume 1

by

Atta-ur-Rahman , Shazia Anjum

DOI: 10.2174/97816080599421150101
eISBN: 978-1-60805-994-2, 2015
ISBN: 978-1-60805-995-9
ISSN: 2352-7633 (Online)



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Stem cell and regenerative medicine research is a hot area of research which promises to change the face of medicine as it will be pra...[view complete introduction]

Table of Contents

Preface

- Pp. i

Atta- ur-Rahman and Shazia Anjum

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List of Contributors

- Pp. ii-iii (2)

Atta- ur-Rahman and Shazia Anjum

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Safety Assessment of Mesenchymal Stem Cells in Musculoskeletal Implantation

- Pp. 3-29 (27)

Greg Asatrian, Angel Pan, Michelle A. Scott and Aaron W. James

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Strategies to Improve Immune Reconstitution After Haematopoietic Stem Cell Transplantation

- Pp. 30-64 (35)

Guy Klamer, Sylvie Shen, Ning Xu, Tracy A. O`Brien and Alla Dolnikov

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Alternative Biomaterial Substrates for Human Embryonic Stem Cell Culture

- Pp. 65-91 (27)

Deepak Kumar, Ying Yang and Nicholas R. Forsyth

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Frontiers in Regenerative Medicine for Cornea and Ocular Surface

- Pp. 92-138 (47)

Maria P. De Miguel, Ricardo P. Casaroli-Marano, Nuria Nieto-Nicolau, Eva M. Martínez-Conesa, Jorge L. Alió del Barrio, Jorge L. Alió, Sherezade Fuentes and Francisco Arnalich-Montiel

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Subject Index

- Pp. 139-144 (6)

Atta- ur-Rahman and Shazia Anjum

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Preface

Research on stem cells is progressing with leaps and bounds, transforming the face of medicine as it will be practiced tomorrow. This is reflected in the award of a Nobel Prize to Gurdon and Yamanaka for their seminal contributions in stem cells research. The first volume of 'Frontiers in Stem Cell and Regenerative Medicine Research' features reviews written by experts in important areas of stem cells and regenerative medicine.

In the opening chapter James et al. describe the safety assessment of mesenchymal stem cells (MSC) in musculoskeletal implantation that can bridge the gap between translation from animals to humans. Current practices and techniques are briefly presented across three common types of MSC differentiation: bone, cartilage, and muscle tissue. The authors have emphasized the importance of in depth safety assessments in MSC implantation. The review explores the current laboratory practices for the safety assessments of MSC implantation from several angles such as histopathology, cytopathology and cytogenetics.

Dolnikov et al. in chapter 2 shed light on the prevalent strategies to improve immune reconstitution after haematopoietic stem cell transplantation. Immunologic reconstitution is critically important for the successful outcome of haematopoietic stem cell transplantation. This is because chemotherapy and pretransplant conditioning impairs thymic function. This can lead to delayed T-cell regeneration, increased risk of opportunistic infections and relapse in cases of leukaemia. Administration of γ-chain cytokines such as IL-2, IL-7 and IL-15 can promote immune reconstitution. Moreover, cell therapy appears to be a promising therapeutic approach to improve immune reconstitution after transplantation.

Forsyth et al. in the next chapter discuss the use of alternative biomaterial substrates for human embryonic stem cell culture. These present exciting opportunities for tissue engineering and regenerative medicine. The authors emphasise the use of nanofibrous substrates as an alternative tool for the expansion and differentiation of embryonic stem cells. In future, such technologies could promote the use of hESC-derived cells for clinical applications.

Finally Miguel et al. discuss the applications of regenerative medicine for repair of damaged cornea and ocular surfaces. The novel techniques that have been presented will help to treat patients with autologous grafts, and can prevent the use of precious corneal stem cells. Both limbal and extraocular stem cells have been tested clinically. These techniques for tissue engineering of functional corneal equivalents represent a new and fascinating way to treat corneal diseases.

We would like to express our sincere thanks to the editorial staff of Bentham Science Publishers, particularly Ms. Maria Baig and Mr. Mahmood Alam for their constant help and support.

Atta-ur-Rahman, FRS
Kings College
University of Cambridge
Cambridge
UK

&

Shazia Anjum
Department of Chemistry
Cholistan Institute of Desert Studies
The Islamia University of Bahawalpur
Pakistan

List of Contributors

Editor(s):
Atta-ur-Rahman
Kings College
University of Cambridge
Cambridge
UK


Shazia Anjum
Department of Chemistry
Cholistan Institute of Desert Studies
The Islamia University of Bahawalpur
Pakistan




Contributor(s):
Aaron W. James
Department of Pathology and Laboratory Medicine
University of California, Los Angeles
David Geffen School of Medicine
Los Angeles
California 90095
USA


Angel Pan
Department of Pathology and Laboratory Medicine
University of California, Los Angeles
David Geffen School of Medicine
Los Angeles
California 90095
USA


Deepak Kumar
Institute of Science and Technology in Medicine
University of Keele
Thornburrow Drive, Hartshill, Stoke-on-Trent
Staffordshire
ST4 7QB
UK


Dolnikov A.
Children’s Cancer Institute Australia for Medical Research
Lowy Cancer Research Institute, University of New South Wales
Sydney
NWS
Australia
/
Kids Cancer Centre, Sydney Children's Hospital
Lowy Cancer Research Institute, University of New South Wales
Randwick
NWS
Australia
/
School of Women and Children's Health
University of New South Wales
NWS
Australia


Eva M. Martínez-Conesa
Transplant Services Foundation (TSF) at Hospital Clinic de Barcelona
Spain



Francisco Arnalich-Montiel
Ophthalmology Department
Ramon y Cajal Hospital
Madrid
Spain


Greg Asatrian
Department of Pathology and Laboratory Medicine
University of California, Los Angeles
David Geffen School of Medicine
Los Angeles
California 90095
USA


Jorge L. Alió
Vissum Ophthalmological Institute and Miguel Hernandez University
Alicante
Spain


Jorge L. Alió del Barrio
Ophthalmology Department
Ramon y Cajal Hospital
Madrid
Spain


Klamer G.
Children’s Cancer Institute Australia for Medical Research
Lowy Cancer Research Institute, University of New South Wales
Sydney
NWS
Australia
/
Kids Cancer Centre, Sydney Children's Hospital
Lowy Cancer Research Institute, University of New South Wales
Randwick
NWS
Australia
/
School of Women and Children's Health
University of New South Wales
NWS
Australia


Maria P. De Miguel
Cell Engineering Laboratory
IdiPAZ, La Paz Hospital Research Institute
Madrid
Spain


Michelle A. Scott
Department of Pathology and Laboratory Medicine
University of California
David Geffen School of Medicine
Los Angeles
California 90095
USA


Nicholas R. Forsyth
Institute of Science and Technology in Medicine
University of Keele
Thornburrow Drive Hartshill Stoke-on-Trent
Staffordshire
ST4 7QB
UK


Nuria Nieto-Nicolau
Transplant Services Foundation (TSF) at Hospital Clinic de Barcelona
Spain



O’Brien T. A.
Children’s Cancer Institute Australia for Medical Research
Lowy Cancer Research Institute, University of New South Wales
Sydney
NWS
Australia
/
Kids Cancer Centre, Sydney Children's Hospital
Lowy Cancer Research Institute, University of New South Wales
Randwick
NWS
Australia
/
School of Women and Children's Health
University of New South Wales
NWS
Australia


Ricardo P. Casaroli-Marano
Transplant Services Foundation (TSF) at Hospital Clinic de Barcelona
Spain
/
Department of Surgery
School of Medicine at University of Barcelona
Barcelona
Spain


Sylvie Shen
Children’s Cancer Institute Australia for Medical Research
Lowy Cancer Research Institute, University of New South Wales
Sydney
NWS
Australia
/
Kids Cancer Centre, Sydney Children's Hospital
Lowy Cancer Research Institute, University of New South Wales
Randwick
NWS
Australia
/
School of Women and Children's Health
University of New South Wales
NWS
Australia


Sherezade Fuentes
Cell Engineering Laboratory
IdiPAZ, La Paz Hospital Research Institute
Madrid
Spain


Xu N.
Children’s Cancer Institute Australia for Medical Research
Lowy Cancer Research Institute, University of New South Wales
Sydney
NWS
Australia
/
Kids Cancer Centre, Sydney Children's Hospital
Lowy Cancer Research Institute, University of New South Wales
Randwick
NWS
Australia
/
School of Women and Children's Health
University of New South Wales
NWS
Australia


Ying Yang
Institute of Science and Technology in Medicine
University of Keele
Thornburrow Drive, Hartshill, Stoke-on-Trent
Staffordshire
ST4 7QB
UK




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