Advances in Modern Medicine


Kiyomi Taniyama, Wataru Kamiike

eISBN: 978-1-68108-023-9, 2017
ISBN: 978-1-68108-024-6

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Table of Contents

Cancer Counseling and Pathology Clinic

- Pp. 3-12 (10)

Takako Nakanishi, Kyoko Kosugi, Chidori Teraoka, Terumi Aoshiba, Kazuya Kuraoka and Kiyomi Taniyama

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Novel Strategy for Treatment in Type 2 Diabetes Mellitus: Targeting Systemic and Adipose Tissue Inflammation

- Pp. 3-9 (7)

Nozomu Kamei

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Toward Enhancement of Research Activities in Clinical Medicine

This publication was planned to celebrate the 10-year anniversary of the Institute for Clinical Research, Kure Medical Center and Chugoku Cancer Center (KMCCCC). Dr. Kiyomi Taniyama has served as the director of this institute throughout these 10 years. In addition, the publication is intended to commemorate the contributions and dedication of Dr. Wataru Kamiike, the president of KMCCCC, who will retire from his position in July.

The city of Kure, home to Kure Medical Center, used to be one of Japan’s major naval bases. After World War II, operation of the Kure Naval Hospital was taken over by the United Nations. The hospital was transferred to the Japanese government 10 years later and began to serve the Japanese people as a national hospital. Since then, KMCCCC has stood as the leading hospital in the Chugoku-Shikoku region. The role of the center has not been limited to clinical services for people in the Kure area, however. The center has also been expected to enhance and advance research activities in clinical medicine. The Institute for Clinical Research, KMCCCC was established and has functioned for this purpose.

Japan is generally acknowledged as a nation with the highest standards and achievements in scientific research. This is true for basic research such as research to elucidate the molecular mechanism of diseases. However, Japan’s achievements in clinical investigation are somewhat limited. International rankings of research activities have listed Japan 3rd in the field of basic medical sciences, but 18th in clinical medicine.

The National Hospital Organization is expected to encourage each member hospital to enhance its research activities in clinical medicine, including case reports, case-controlled studies, clinical trials, and cohort studies. Progress in medicine has been accomplished only through careful observation of clinical cases. Evidence that is inevitably needed for daily clinical decision making is only possible through documentation of clinical experiences.

We anticipate that the strength of research at the Institute for Clinical Research, KMCCCC, led by Dr. Taniyama, will continue to grow; it is our hope that the institute will contribute significant advancements to the medical sciences well into the future.

Takaaki Kirino M.D., Ph.D.
National Hospital Organization, Tokyo, Japan

10 Glorious Years for the National Hospital Organization Kure Medical Center and Chugoku Cancer Center

I want to express my great appreciation to Dr. Wataru Kamiike, president of national hospital organization (NHO) Kure Medical Center and Chugoku Cancer Center (KMCCCC), for his 10 years of significant contributions to the hospital. In his first five years, he helped me in his role as vice president to reengineer hospital management and in the second five years he managed the hospital as its president. Over the past decade, KMCCCC has made remarkable progress in both clinical and financial performance, which resulted in the hospital being acknowledged as one of the best hospitals among the more than 140 hospitals within the NHO. I believe that our highly advanced medical treatment and diligent nursing by the hospital staff have produced these outstanding results.

Publication of this eBook titled "Advances in modern medicine during the last decade" upon Dr. Kamiike's retirement and the tenth anniversary of Dr. Taniyama as director of the Clinical Research Institute affiliated with KMCCCC is extremely timely.

Dr. Taniyama will serve as the next president of KMCCCC. He has also contributed to the hospital’s distinguished development in both basic and clinical research. He is a highly regarded scientist in the field of clinical pathology not only domestically but also internationally. The memorandum of understanding between KMCCCC and Rajavithi Hospital in Thailand, the Kure International Medical Forum, and other international activities could not have been a great successes without his effort.

I thank everyone who has contributed to this eBook. I hope its publication will be a key milestone for the KMCCCC and that the center continues to grow and contribute to the advancement of modern medicine.

Fumitaka Saji M.D., PhD.
Honorary President
NHO Kure Medical Center & Chugoku Cancer Center
Kure, Japan
CEO, Ashiya Municipal Hospital, Ashiya, Japan

Congratulatory Message for Dr. Kiyomi Taniyama, Kure Medical Center

It is my great honor and pleasure to write this congratulatory message for Dr. Kiyomi Taniyama on the occasion of the publication of his eBook, Advances in Modern Medicine during the Last Decade which coincides with the tenth anniversary of his chairmanship at the Institute for Clinical Research and his appointment as the President of National Hospital Organization Kure Medical Center and Chugoku Cancer Center (KMCCCC).

This eBook has taken up basic science, translational research and modern medicine in relation to both diagnosis and treatment, and reviews the latest cutting-edge therapeutics and diagnostics by KMCCCC's entire staff. I am deeply impressed by the eBook's descriptions of the achievements of the last decade. There is no doubt that this eBook is valuable to medical workers and researchers around the world.

I have known Dr. Taniyama for more than 30 years, since I became a member of the First Department of Pathology at Hiroshima University. Over the years, I have learned much, not only about medicine and pathology but also about social issues. I admire his foresight and action. In addition to his pathology practice and research, he organizes the annual Kure International Medical Forum and collaborates with many medical professionals across Asia. He is a leader and makes the resources of the Pathology Clinic available to cancer patients in Japan. When I, as the President, hosted the 103rd Annual Meeting the Japanese Society of Pathology in April 2014, he chaired the program committee of diagnostic pathology and ensured the great success of the meeting.

I wish Dr. Taniyama and his colleagues in KMCCCC all the best for a bright future. As the Director of Institute of Biomedical & Health Sciences, Hiroshima University, I look forward to our collaboration to achieve our goal of an even better understanding and treatment of our patients and the improvement of human health worldwide.

Wataru Yasui, M.D., Ph.D.
Distinguished Professor
Professor and Chairman, Department of Molecular Pathology
Director, Institute of Biomedical Health Sciences
Dean, Graduate School of Biomedical & Health Sciences
Hiroshima University, Hiroshima, Japan


The National Hospital Organization (NHO) of Japan was rebuilt from the former National Hospitals of Japan 10 years ago in 2004. At almost the same time, Dr. Kiyomi Taniyama obtained his position as the director of the clinical research institute affiliated with the NHO Kure Medical Center and Chugoku Cancer Center (KMCCCC), Kure, Japan. Over the last decade, he has organized his research institute well and obtained many good results with the collaboration of the basic and translational research staff. Because the systems and equipment are often upgraded to keep pace with the latest trends in medicine, remarkable medical advances have been achieved during the last decade in our hospital, which is representative of the progress made in modern medicine, not only in Japan, but also around the world.

On June 30, 2014, Dr. Wataru Kamiike, is going to retire from the president of NHOKMCCCC that is one of the top five hospitals among the 143 NHO hospitals in Japan. Therefore, July in 2014 is a good time to celebrate Dr. Taniyama’s ten-year history as the director of clinical research center and promotion to the next president, as well as the retirement of Dr. Kamiike from the president. Fundamentally, this eBook will be a memorable token of this celebration, but it also represents the latest trends in modern medicine, covering a wide range of fields. As previously mentioned, this eBook will cover basic science, translational research, and modern medicine in relation to both diagnosis and treatment. This eBook will be full of reviews of cutting edge therapies and diagnostic techniques related to the fields of the authors, along with original articles with the latest data obtained by the authors.

Kiyomi Taniyama, MD, PhD.
Former Director, Institute for Clinical Research,
President, NHO KMCCCC, Kure, Japan.
Wataru Kamiike, MD, PhD.
Honorary President, NHO KMCCCC, Kure, Japan

List of Contributors

Kiyomi Taniyama

Wataru Kamiike


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