The Yin and Yang of Von Willebrand Factor in Thrombosis and Hemostasis: Lessons from Von Willebrand Disease and Thrombotic Thrombocytopenic Purpura
- Pp. 260-272 (13)Toshiro Takafuta, Makoto Kaneko and Isaku Shinzato
Various factors, including platelets, endothelial cells, and coagulation factors, regulate the mechanisms of thrombosis and hemostasis. Von Willebrand factor (VWF) is one of the key molecules to initiate platelets adhesion and aggregation. Quantitative and qualitative VWF abnormalities cause both hemorrhagic and thrombotic disorders. The role of VWF has emerged from molecular mechanisms of von Willebrand disease (VWD) and thrombotic thrombocytopenic purpura (TTP). This review summarizes the current knowledge of these diseases and the importance of VWF in thrombosis and hemostasis.