Septic Cardiomyopathy: from bench-to-bedside

Book Series: Frontiers in Myocardia

Volume 1

by

Vasilios E. Papaioannou

DOI: 10.2174/97816810806041150101
eISBN: 978-1-68108-060-4, 2015
ISBN: 978-1-68108-061-1
ISSN: 2451-8344 (Print)
ISSN: 2451-8352 (Online)



Recommend this eBook to your Library



Frontiers in Myocardia is an eBook series which compiles information about the ...[view complete introduction]

Table of Contents

Foreword

- Pp. i

Michael R. Pinsky

Download Free

Preface

- Pp. ii-iii (2)

Vasilios E. Papaioannou

Download Free

List of Contributors

- Pp. iv-v (2)

Vasilios E. Papaioannou

Download Free

Introduction

- Pp. vi

Vasilios E. Papaioannou

Download Free

Potential Pathophysiological Mechanisms in Septic Cardiomyopathy: an Overview

- Pp. 3-40 (38)

Karl Werdan, Sebastian Nuding and Ursula Müller-Werdan

View Abstract Download Free

Cellular and Molecular Mechanisms of Septic Cardiomyopathy

- Pp. 41-56 (16)

Jamison J. Grailer and Peter A. Ward

View Abstract Purchase Chapter

Cellular Electrophysiological Mechanisms in Septic Cardiomyopathy

- Pp. 57-84 (28)

Brigitte Pelzmann, Susanne Scheruebel and Klaus Zorn-Pauly

View Abstract Download Free

Septic Cardiomyopathy: A Distinct Histopathological Entity

- Pp. 85-103 (19)

Maria José Figueiredo, Ana Caroline Silva de Freitas, Érica Carolina Campos, Danilo Figueiredo Soave, Simone Gusmão Ramos and Mara Rúbia N. Celes

View Abstract Download Free

Septic Cariomyopathy: A Distinct Metabolic and Genetic Entity?

- Pp. 104-115 (12)

Jochen Hinkelbein

View Abstract Purchase Chapter

Clinical and Molecular Aspect of Septic Cardiomyopathy: Basic Concepts

- Pp. 116-131 (16)

Gilles Clermont

View Abstract Purchase Chapter

The Clinical Aspects of Septic Myocardiopathy

- Pp. 132-139 (8)

Sabri Soussi and Matthieu Legrand

View Abstract Purchase Chapter

Septic Cardiomyopathy: an Echocardiographic Approach

- Pp. 140-153 (14)

Hélène Nougue, Alexandre Mebazaa and Etienne Gayat

View Abstract Purchase Chapter

Which Biomarkers Can I Use to Manage Septic Cardiomyopathy

- Pp. 154-163 (10)

Anaïs Caillard, Etienne Gayat, Dahdouh Souheila and Alexandre Mebazaa

View Abstract Purchase Chapter

Current and New Therapeutic Interventions in Septic Cardiomyopathy

- Pp. 164-175 (12)

Daniel De Backer

View Abstract Purchase Chapter

Tachycardia and Its Pathophysiological Implications in Septic Myocardial Dysfunction

- Pp. 176-187 (12)

Andrea Morelli and Maurizio Passariello

View Abstract Purchase Chapter

Septic Cardiomyopathy: Quo Vadis? From Past-to-the Future

- Pp. 188-212 (25)

James J. Douglas, John H. Boyd and Keith R. Walley

View Abstract Purchase Chapter

Subject Index

- Pp. 213-214 (2)

Vasilios E. Papaioannou

Download Free

Foreword

Sepsis is a systematic process that involves all cells and at all levels from intracellular genomic expression, subcellular organelle especially mitochondrial function, cell signaling and organ function. It would be amazing if sepsis did not also alter myocardial function. However, unlike simple ischemic heart disease, the mechanisms and expression of septic cardiomyopathy is more complex and often confusing. This new eBook addresses the various aspects of these processes in a single volume. The authors are all leaders in this field and their insights offer a clear pathway toward understanding the field as it is now and where it is going. I recommend this volume to any acute care physician and scientist whose focus is critical illness and whose goal is to improve the care of the critically ill septic patient.

Michael R. Pinsky
Department of Critical Care Medicine
606 Scaife Hall, 3550 Terrace Street, University of Pittsburgh Medical Center,
Pittsburgh, PA 15261,
USA,
Tel: (412) 647-7766,
Fax: (412) 647-8060
E-mail: e.pinskymr@upmc.edu


Preface

Severe sepsis and septic shock are the most common scenarios that a caring physician may deal with, when he is treating a critically ill patient in the Intensive Care Unit (ICU). Moreover, early signs of severe infection associated with organ dysfunction might appear when a patient is treated in a medical or surgical ward, within a hospital. Thus, early diagnosis and prompt treatment are of paramount importance for improving survival of these patients.

One of the most significant complications of sepsis is the cardiovascular compromise, mostly due to a vasoplegia induced by different cytokines that are produced during systemic inflammation. In addition, both left and right systolic and diastolic dysfunction has been proven to occur in the course of severe sepsis. This cardiomyopathy, as has been shown from Parrillo and Parker in the 80’ using portable radionuclide cardiac imaging and thermodilution cardiac output measurements, is usually reversible within 7-10 days, whereas different echocardiographic studies by Jardin and Baron since the 90’ have confirmed left and right systolic dysfunction. In these cases, conventional estimators of ventricular function, such as cardiac output and ejection fraction (EF), lack both sensitivity and specificity for accurate assessment of heart performance, either due to significant afterload reduction or due to severe pulmonary hypertension and alterations in left ventricular compliance.

There is a lot of debate in the literature regarding potential pathogenetic mechanisms of septic cardiomyopathy, such as membrane ionic current remodeling, cardiomyocyte apoptosis, different circulating depressive factors or autonomic nervous system (ANS) output effects. In any case, both animal experiments and human echocardiographic studies reveal that intrinsic mechanisms can be adaptative, leading to a sort of myocardial hibernation, or maladaptative, producing severe cellular stress with associated necrosis or apoptosis. Current treatment of septic shock other than antimicrobial treatment include fluid load, vasopressors and/or positive inotropic agents, which might induce calcium overload and deteriorate cellular stress, similar with band necrosis observed in stress-associated cardio-myopathy or the apical ballooning syndrome.

In conclusion, we think that the topic of septic cardiomyopathy remains significantly obscured, since there is a lot but scarred information in the literature concerning molecular or electrophysiological pathophysiological mechanisms, diagnostic and therapeutic interventions, monitoring tools, and specific treatment options.

The aim of this ebook is to gather scientists from different disciplines in order to provide thorough and concise information regarding all aspect of this ‘disease’, from electrophysiological and cellular alterations to clinical, laboratory and imaging technological advances. In addition, it will present novel data concerning new promising treatments, in the context of septic shock management in the ICU.

Vasilios E. Papaioannou

Democritus University of Thrace,
Intensive Care Unit, Alexandroupolis Hospital,
Dragana 68100,
Greece,
Tel: 0030255105083
E-mail: vapapa@med.duth.gr

List of Contributors

Editor(s):
Vasilios E. Papaioannou
Democritus University of Thrace, Intensive Care Unit
Alexandroupolis Hospital
Dragana, 68100
Greece




Contributor(s):
Daniel de Backer
Free University of Brussels
Erasme Hospital, Intensive Care Unit
Brussels, B-1070
Belgium


John H. Boyd
Center for Heart Lung Innovation (HLI)
University British Columbia, St Paul’s Hospital
Vancouver, V6Z 1Y6
Canada


Anaïs Caillard
University Paris 7 Denis Diderot, AP-HP,
Department of Anesthesiology and Critical Care Medicine
Lariboisiere Hospital
Paris, 7545
France


Érica Carolina Campos
Department of Physical Education and Physiotherapy
Clinical Hospital of Federal University of Uberlandia
MG, 74605-050
Brazil


Maria N. Celes
Department of Pathology
Institute of Tropical Pathology and Public Health - IPTSP
Federal University of Goias - UFG
Goiania
GO, 74605-050
Brazil


Gilles Clermont
University of Pittsburgh
Department of Critical Care Medicine
McGowan Institute for Regenerative Medicine
Piitsburgh
PA
USA


James J. Douglas
Center for Heart Lung Innovation (HLI)
University British Columbia
St Paul’s Hospital
Vancouver, V6Z 1Y6
Canada


Maria José Figueiredo
Department of Pathology, Faculty of Medicine of Ribeirao Preto
University of Sao Paulo
Ribeirao Preto
SP, 74605-050
Brazil


Ana Caroline Silva de Freitas
Department of Pathology, Faculty of Medicine of Ribeirao Preto
University of Sao Paulo
Ribeirao Preto
SP, 74605-050
Brazil


Etienne Gayat
University Paris 7 Denis Diderot, AP-HP
Department of Anesthesiology and Critical Care Medicine
Lariboisiere Hospital
Paris, 7545
France


Jamison J. Grailer
Department of Pathology
University of Michigan Medical School
Ann Arbor
MI, 48109
USA


Jochen Hinkelbein
Anesthesiology and Surgical Intensive Care Clinic
University of Cologne
Kerpener Str. 62, 50937
Germany


Matthieu Legrand
University Paris 7 Denis Diderot, AP-HP
Groups Hospitalier Universitaire Lariboisiere-St Louis
Groups Hospitalier Universitaire Lariboisiere-St Louis
Paris, 7545
France


Alexandre Mebazaa
University Paris 7 Denis Diderot, AP-HP
Department of Anesthesiology and Critical Care Medicine
Lariboisiere Hospital
Paris, 7545
France


Andrea Morelli
Professor of Anesthesiology and Intensive Care
University of Roma la Sapienza
Rome, 00161
Italy


Hélène Nougue
Department of Anesthesiology and Critical Care Medicine
University Paris 7 Denis Diderot, AP-HP, Lariboisiere Hospital
Paris, 7545
France


Sebastian Nuding
Department of Medicine III and Heart Centre of the University Hospital Halle D-06120 (Saale)
Martin-Luther-University Halle (Saale)
06108 Halle (Saale)
Germany


Maurizio Passariello
Department of Cardiovascular, Respiratory, Nephrological, Anesthesiological and Geriatric Sciences
University of Rome ‘La Sapienza’
Rome, 00161
Italy


Klaus Zorn-Pauly
Institut für Biophysik
Medizinische Universitat Graz
8010 Graz
Austria


Brigitte Pelzmann
Institut für Biophysik
Medizinische Universitat Graz
8010 Graz
Austria


Simone Gusmão Ramos
Department of Pathology, Faculty of Medicine of Ribeirao Preto
University of Sao Paulo
Ribeirao Preto
SP, 74605-050
Brazil


Susanne Scheruebel
Institut für Biophysik
Medizinische Universitat Graz
8010 Graz
Austria


Danilo Figueiredo Soave
Department of Pathology, Faculty of Medicine of Ribeirao Preto
University of Sao Paulo
Ribeirao Preto
SP, 74605-050
Brazil


Dahdouh Souheila
Department of Anesthesiology and Critical Care Medicine
University Paris 7 Denis Diderot, AP-HP, Lariboisiere Hospital
Paris, 7545
France


Sabri Soussi
Department of Anesthesiology Surgical Intensive Care and Burn Unit
University Paris 7 Denis Diderot, AP-HP, Groups Hospitalier Universitaire Lariboisiere-St. Louis
Paris, 7545
France


Keith Walley
Centre for Heart Lung Innovation and Division of Critical Care Medicine
St. Paul’s Hospital and the University of British Columbia
Vancouver
Canada


Peter A. Ward
Department of Pathology
University of Michigan Medical School
Ann Arbor
MI, 48109
USA


Karl Werdan
Professor of Medicine, Department of Medicine III and Heart Centre of the University Hospital Halle (Saale)
Martin-Luther-University Halle (Saale)
06108 Halle (Saale)
Germany


Ursula Müller-Werdan
Professor of Medicine, Department of Medicine III and Heart Centre of the University Hospital Halle (Saale)
Martin-Luther-University Halle (Saale)
06108 Halle (Saale)
Germany




Advertisement


Related Journals



Related Books



Webmaster Contact: info@benthamscience.org Copyright © 2017 Bentham Science