Chapter 12

Septic Cardiomyopathy: Quo Vadis? From Past-to-the Future

James J. Douglas, John H. Boyd and Keith R. Walley

Abstract

Sepsis remains the most common admission diagnosis to ICU and approximately half of these patients develop some form of cardiac dysfunction. Genetic factors, large vessel and microcirculatory changes, depressant factors, metabolic changes, autonomic dysregulation and a myriad of cellular regulators have all been implicated in the myocardial dysfunction. The cardiomyopathy is reversible may include elements of LV and RV systolic and diastolic dysfunction. Current approaches to treatment include guideline based septic shock therapy often along with inotropic support, however a new approach may include heart rate control.

Total Pages: 188-212 (25)

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