Depression: A Silent Culprit in Health and Disease


by

Puneetpal Singh

DOI: 10.2174/97816810814581150101
eISBN: 978-1-68108-145-8, 2015
ISBN: 978-1-68108-146-5



Recommend this eBook to your Library



Depression is considered as a complex problem with potentially serious economic consequences for affected individuals as well as publi...[view complete introduction]

Table of Contents

Preface

- Pp. i-ii (2)

Puneetpal Singh

Download Free

List of Contributors

- Pp. iii

Puneetpal Singh

Download Free

Depression: It Matters!

- Pp. 3-24 (22)

Ana María Sánchez Peralta

View Abstract Purchase Chapter

P300 Wave in Depression: An Update

- Pp. 25-49 (25)

Ravi Prakash, Srinivasa R. and Priyanka Rastogi

View Abstract Purchase Chapter

The Impact of Aging on Post-Stroke Depression

- Pp. 51-67 (17)

Ana-Maria Buga, Madalina Filfan, Badescu M. George and Aurel Popa- Wagner

View Abstract Download Free

Molecular Insights into Depression in the Genomic Era

- Pp. 69-81 (13)

Manjit Singh and Changanamkandath Rajesh

View Abstract Purchase Chapter

Diffusion Tensor Imaging Techniques: Insights into Alterations of White Matter Underlying Major Depression and Suicidal Behavior

- Pp. 83-127 (45)

Gianluca Serafini, Matteo Respino, Martino Belvederi Murri and Mario Amore

View Abstract Purchase Chapter

Subject Index

- Pp. 129-134 (6)

Puneetpal Singh

Download Free

Preface

This book is about depression, a malady which has tethered to almost every disease condition and metastasized in every section and every phase of life. It discriminates none, remains silent but in due course of time, manifests in a very loud manner. Despite the fact that it is associated significantly to some of the dreaded diseases, it is often considered as an artefact of age or of concomitant health problem and usually not considered amenable to intervention by health practitioners and general physicians. In the last couple of years, researchers have heralded various risk factors that can contribute to depression and documented their preventive measures, but every time, it appears that it is more complex than what we know so far.

The present eBook, “Depression: A Silent Culprit in Health and Disease” is aimed to consolidate state of the art knowledge from scholars of high repute who have contributed immensely in the field of depression. This treatise tries to bring comprehensive review of latest technological advances in understanding and diagnosing depression, its genetic causes and concerns along with post-stroke consequences which impinge substantially upon health and disease.

In the first chapter, “Depression: It Matters!” author Ana Maria Sanchez Peralta has familiarized about the neurotransmitters, which are present in central nervous system and serve as chemical messengers that transmit signal across synapse from one neuron to another. Imbalance of these endogenous chemicals triggers depression and extent of their imbalance decides severity of depression. She has elaborately discussed various forms of anti-depressants and their adverse effects, withdrawal aftermaths and contraindications. Therapies to treat depression vary according to its presence in different diseases, information given regarding this in the chapter is noteworthy and justifies that it matters.

Apropos to every query submitted, a musical event is organized in the hall of brain, where central nervous system plays melodious concert and millions of neurons dance to perform synchronized ballet. This symphonized answer can be understood by a rhythmic wave named P300, musicality of which has been interrogated in the second chapter by Prakash et al. This chapter engrosses the attention that neurophysiological examination of P300 wave can comprehend the different layers of depression and putforth that application of P300 wave in clinical settings has tremendous potential in diagnostic and prognostic modalities in major depressive disorder.

Third chapter emphasizes that many stroke survivors undergo depression which can be exacerbated by advancing age and if remains untreated, may lead to adverse outcomes and even mortality. In order to understand the age specific depression after stroke and its preventive measures, authors have pointed out several molecular and cellular mechanisms that can contribute to it, while ageing. Some screening instruments and therapeutic strategies for post-stroke depression have also been discussed, which help us to control depression, which otherwise has formidable impact after ischemic stroke in ageing brain.

Fourth chapter emerges from the query that whether gene and genome wide association studies precisely infer genetic contributions for the risk of depression in post genomic era. Albeit, this chapter by Singh et al. revolves around the genetic, epigenetic and pharmacogenetic concerns of depression, but persuades to realize that the concept of ‘Personal Medicine’ proposed by scientists, by which every person will be treated according to the genes one carries, appears to be a distant dream.

Gianluca Serafini and co-workers have browsed seventy published research papers to uncover the utility of diffusion tensor imaging techniques for understanding brain white matter abnormalities in relation to pathophysiology of major depressive disorder and suicidal behavior. They have deduced that microstructural white matter abnormalities located in neural circuits are critically involved in emotional processes and mood regulation, which may result in enhanced vulnerability to psychiatric morbidity contributing to functional impairments. This review chapter offers an indepth understanding of the current knowledge and applicability of diffusion tensor imaging techniques in major depression and suicidal ideation.

I am deeply indebted to Ms. Shallu Khullar for her extended help in style editing of the book. I extend my heartfelt gratitude to Ms. Humaira Hashmi, In-charge eBook department and editorial manager publications, Ms. Maria Baig, Manager Publications and especially Mr. Mahmood Alam, Director Publications, Bentham Science Publishers for their kind support, encouragement and help.

Puneetpal Singh
Department of Human Genetics
Punjabi University, Patiala
India

List of Contributors

Editor(s):
Puneetpal Singh
Department of Human Genetics
Patiala
India




Contributor(s):
Ana-Maria Buga
Department of Psychiatry and Psychotheraphy
University of Medicine Rostock
Rostock
Germany
/
Center of Clinical and Experimental Medicine
University of Medicine and Pharmacy Craiova
Craiova
Romania


Ana María Sánchez Peralta
Granada University of Pharmacy
Department of Food Science and Physical Chemistry, La Cartuja
Granada
Spain


Aurel Popa-Wagner
Department of Psychiatry and Psychotheraphy, Aging & Psychiatric Disorders Group
Brunel University
Gehlsheimer Straβe 20 D-18147
Rostock
Germany


Badescu M. George
Clinic of Psychiatry, University of Medicine and Pharmacy Craiova
Craiova
Romania


Changanamkandath Rajesh
Department of Biotechnology
Sri Guru Granth Sahib World University
Fatehgarh Sahib -140406
Punjab
India


Gianluca Serafini
Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI)
Section of Psychiatry, University of Genoa, IRCCS San Martino
Largo Rosanna Benzi 10, 16100
Genoa
Italy


Madalina Filfan
Center of Clinical and Experimental Medicine
Craiova
Romania
/
Clinic of Psychiatry
Craiova
Romania


Manjit Singh
Department of Biotechnology
Sri Guru Granth Sahib World University
Fatehgarh Sahib-140406
Punjab
India


Mario Amore
Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI)
Section of Psychiatry, University of Genoa, IRCCS San Martino
Largo Rosanna Benzi 10, 16100
Genoa
Italy


Martino Belvederi Murri
Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI)
Section of Psychiatry, University of Genoa, IRCCS San Martino
Largo Rosanna Benzi 10, 16100
Genoa
Italy


Matteo Respino
Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI)
Section of Psychiatry, University of Genoa, IRCCS San Martino
Largo Rosanna Benzi 10, 16100
Genoa
Italy


Priyanka Rastogi
Clinical Psychologist & Free-lance Researcher
Sai Krupa Hospital
Mathikere, Bangalore, 560054
India


Ravi Prakash
Department of Physiology
M.S. Ramaiah Medical College
Mathikere, Bangalore, 560054
India


Srinivasa R.
Department of Neurology
M.S. Ramaiah Medical College
Bangalore, 560054
India




Advertisement


Related Journals



Related Books



Webmaster Contact: urooj@benthamscience.org Copyright © 2017 Bentham Science