Frontiers in Medicinal Chemistry

Volume 8

by

Atta-ur-Rahman , M. Iqbal Choudhary , Allen B. Reitz

DOI: 10.2174/97816810817551160801
eISBN: 978-1-68108-175-5, 2016
ISBN: 978-1-68108-176-2
ISSN: 1567-2042 (Print)
ISSN: 1875-5763 (Online)



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“Frontiers in Medicinal Chemistry” is an eBook series devoted to the review of ...[view complete introduction]

Table of Contents

Preface

- Pp. i

Atta-ur-Rahman, M. Iqbal Choudhary and Allen B. Reitz

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Contributors

- Pp. ii-iv (3)

Atta-ur-Rahman, M. Iqbal Choudhary and Allen B. Reitz

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ADME Optimization and Toxicity Assessment in Drug Discovery

- Pp. 3-60 (58)

Gary W. Caldwell

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The Oxidative Stress Menace to Coronary Vasculature: Any Place for Antioxidants?

- Pp. 61-95 (35)

Alexandros Briasoulis, Charalampos Antoniades, George-Angelo Papamikroulis, Evangelos Oikonomou and Dimitris Tousoulis

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Atherosclerosis, Mitochondrial Dysfunction and Oxidative Stress: Mitochondria-Targeted Antioxidants as Potential Therapy

- Pp. 96-135 (40)

Irene Escribano-Lopez, Noelia Diaz-Morales, Susana Rovira-Llopis, Celia Bañuls, Sandra Lopez-Domenech, Raquel Castelló, Rosa Falcón, Eva Sola, Milagros Rocha, Antonio Hernández-Mijares and Victor M. Víctor

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Endothelial Dysfunction in Diabetes: An Update on Mechanisms and Therapeutic Targets

- Pp. 136-170 (35)

Maria Assunta Potenza, Carmela Nacci, Luca Sgarra, Valentina Leo, Maria Antonietta De Salvia and Monica Montagnani

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Pyridinium Oximes as Cholinesterase Reactivators. An Update of the Structure-Activity Relationship and Efficacy in the Treatment of Poisoning with Organophosphorus Compounds

- Pp. 171-205 (35)

Milan Jokanović and Radica Stepanović Petrović

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Calixarenes in Biotechnology and Bio-Medical Research

- Pp. 206-301 (96)

Roman V. Rodik, Vyacheslav I. Boyko and Vitaly I. Kalchenko

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Index

- Pp. 302-314 (13)

Atta-ur-Rahman, M. Iqbal Choudhary and Allen B. Reitz

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Preface

Volume 8 of Frontiers in Medicinal Chemistry comprises 6 chapters on topics of high importance in the fields of medicinal chemistry and early-stage drug discovery research. The topics and authors were selected from highly cited publications in the Bentham journals Curr. Med. Chem., Curr. Pharm. Des., and Curr. Top. Med. Chem. The original authors were given the opportunity to rewrite their contributions, particularly updating them with more modern insights and references that have emerged in the intervening period of time.

The first chapter by Dr. Gary Caldwell is a tour de force review on the use of ADME optimization and toxicity assessment in drug discovery research. Dr. Caldwell has written multiple chapters on this ever evolving topic and has served as a book editor for Bentham in the past. His chapter in this volume of Frontiers is a valued and updated reference guide in the field. Chapters 2 and 3 by Briasoulis et al. and Escribano-Lopez et al., respectively, cover oxidative stress-mediated approaches to treat cardiovascular diseases such as atherosclerosis. The fourth chapter by Potenza et al. is on diabetes, and in particular endothelial dysfunction and the associated implications as to mechanism and therapeutic targets. In Chapter 5, Jokanović and Petrović review pyridinium oximes as cholinesterase reactivators for the treatment of organophosphorus poisoning. Finally, Rodik and colleagues discuss the current and potential uses of the cyclic macrocyclic oligomer calixarenes in biomedical research.

I would like to express my gratitude to all the authors for their excellent contributions. I would also like to thank the entire team of Bentham Science Publishers, particularly Mr. Omer Shafi (Assistant Manager Publications), Mr. Shehzad Naqvi (Senior Manager Publications) and team leader Mr. Mahmood Alam (Director Publications) for their excellent efforts. We are confident that this volume will receive wide appreciation from students and researchers.

Atta-ur-Rahman, FRS
Honorary Life Fellow, Kings College
University of Cambridge
UK


Iqbal Choudhary
H.E.J. Research Institute of Chemistry
International Center for Chemical and Biological Sciences
University of Karachi
Pakistan


Allen B. Reitz
Chemical Biology, Institute of Hepatitis and Virus Research
CEO, Fox Chase Chemical Diversity Center, Incorporation
Doylestown, PA 18902, USA

List of Contributors

Editor(s):
Atta-ur-Rahman
Honorary Life Fellow
Kings College
University of Cambridge
UK


M. Iqbal Choudhary
H.E.J. Research Institute of Chemistry
University of Karachi
Karachi-75270
Pakistan


Allen B. Reitz
Chief Executive Officer
Fox Chase Chemical Diversity Center, Inc. Pennsylvania Biotechnology Center
3805 Old Easton Road
Doylestown, PA 18902
USA




Contributor(s):
Alexandros Briasoulis
1st Cardiology Department
University of Athens Medical School, “Hippokration” Hospital
Athens
Greece


Antonio Hernández-Mijares
Service of Endocrinology
University Hospital Dr. Peset, Foundation for the Promotion of Health and Biomedical Research in the Valencian Region (FISABIO)
Valencia
Spain


Carmela Nacci
Department of Biomedical Sciences and Human Oncology – Pharmacology Section
Medical School – University of Bari “Aldo Moro”
Bari
Italy


Charalampos Antoniades
1st Cardiology Department
University of Athens Medical School, “Hippokration” Hospital
Athens
Greece


Dimitris Tousoulis
1st Cardiology Department
University of Athens Medical School, “Hippokration” Hospital
Athens
Greece


Eva Sola
Service of Endocrinology
University Hospital Dr. Peset, Foundation for the Promotion of Health and Biomedical Research in the Valencian Region (FISABIO)
Valencia
Spain


Evangelos Oikonomou
1st Cardiology Department
University of Athens Medical School, “Hippokration” Hospital
Athens
Greece


Gary W. Caldwell
Janssen Research & Development, L.L.C. Discovery Sciences, Lead Discovery Department
Welsh and McKean Roads, P.O. Box 776, Spring House, PA 19477
USA


George-Angelo Papamikroulis
1st Cardiology Department
University of Athens Medical School, “Hippokration” Hospital
Athens
Greece


Irene Escribano-Lopez
Service of Endocrinology
University Hospital Dr. Peset, Foundation for the Promotion of Health and Biomedical Research in the Valencian Region (FISABIO)
Valencia
Spain


Luca Sgarra
Department of Biomedical Sciences and Human Oncology – Pharmacology Section
Medical School – University of Bari “Aldo Moro”
Bari
Italy


Maria Antonietta De Salvia
Department of Biomedical Sciences and Human Oncology – Pharmacology Section
Medical School – University of Bari “Aldo Moro”
Bari
Italy


Maria Assunta Potenza
Department of Biomedical Sciences and Human Oncology – Pharmacology Section
Medical School – University of Bari “Aldo Moro”
Bari
Italy


Milagros Rocha
Service of Endocrinology
University Hospital Dr. Peset, Foundation for the Promotion of Health and Biomedical Research in the Valencian Region (FISABIO)
Valencia
Spain


Milan Jokanović
Faculty of Medicine
University of Nish
Nish
Serbia


Monica Montagnani
Department of Biomedical Sciences and Human Oncology – Pharmacology Section
Medical School – University of Bari “Aldo Moro”
Bari
Italy


Noelia Diaz-Morales
Service of Endocrinology
University Hospital Dr. Peset, Foundation for the Promotion of Health and Biomedical Research in the Valencian Region (FISABIO)
Valencia
Spain


Radica Stepanović Petrović
Faculty of Pharmacy
University of Belgrade
Belgrade
Serbia


Raquel Castelló
Service of Endocrinology
University Hospital Dr. Peset, Foundation for the Promotion of Health and Biomedical Research in the Valencian Region (FISABIO)
Valencia
Spain


Roman V. Rodik
Institute of Organic Chemistry
National Academy of Sciences of Ukraine
Ukrain


Rosa Falcón
Service of Endocrinology
University Hospital Dr. Peset, Foundation for the Promotion of Health and Biomedical Research in the Valencian Region (FISABIO)
Valencia
Spain


Sandra Lopez-Domenech
Service of Endocrinology
University Hospital Dr. Peset, Foundation for the Promotion of Health and Biomedical Research in the Valencian Region (FISABIO)
Valencia
Spain


Susana Rovira-Llopis
Service of Endocrinology
University Hospital Dr. Peset, Foundation for the Promotion of Health and Biomedical Research in the Valencian Region (FISABIO)
Valencia
Spain


Valentina Leo
Department of Biomedical Sciences and Human Oncology – Pharmacology Section
Medical School – University of Bari “Aldo Moro”
Bari
Italy


Victor M. Víctor
Service of Endocrinology
University Hospital Dr. Peset, Foundation for the Promotion of Health and Biomedical Research in the Valencian Region (FISABIO)
Valencia
Spain


Vitaly I. Kalchenko
Institute of Organic Chemistry
National Academy of Sciences of Ukraine
Ukraine


Vyacheslav I. Boyko
Institute of Organic Chemistry
National Academy of Sciences of Ukraine
Ukraine




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