Frontiers in Clinical Drug Research- Central Nervous System

Volume 2

by

Atta-ur-Rahman

DOI: 10.2174/97816810818921160201
eISBN: 978-1-68108-190-8, 2016
ISBN: 978-1-68108-189-2
ISSN: 2467-9623 (Print)
ISSN: 2214-6318 (Online)



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Indexed in: EBSCO.

Frontiers in Clinical Drug Research – Central Nervous System presents the lates...[view complete introduction]

Table of Contents

Preface

- Pp. i

Atta-ur-Rahman

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List of Contributors

- Pp. ii

Atta-ur-Rahman

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Nucleic Acids as Drugs for Neurodegenerative Diseases

- Pp. 3-104 (102)

Maria Rita Micheli, Rodolfo Bova, Mario Polidoro and Carla Emiliani

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Cellular Cysteine Network (CYSTEINET): Pharm-acological Intervention in Brain Aging and Neurodegenerative Diseases

- Pp. 105-172 (68)

Marcos Arturo Martínez Banaclocha

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Non-motor Symptoms in Parkinson’s Disease and Drug Therapies

- Pp. 173-185 (13)

Kazuo Abe

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Alpha 7 Nicotinic Receptor Agonist Modulatory Interactions with Melatonin: Relevance not only to Cognition, but to Wider Neuropsychiatric and Immune Inflammatory Disorders

- Pp. 186-202 (17)

George Anderson and Michael Maes

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Multi-modal Pharmacological Treatments for Maj-or Depressive Disorder: Testing the Hypothesis

- Pp. 203-231 (29)

Trevor R. Norman

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Subject Index

- Pp. 232-240 (9)

Atta-ur-Rahman

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Preface

The second volume of the eBook series entitled: “Frontiers in Clinical Drug Research – Central Nervous System” comprises five chapters in cutting edge fields. In the first chapter, Micheli etal highlight the potential of nucleic acids as drugs for neurodegenerative diseases. Till date, various types of nucleic acidbased therapeutics have been proposed. This chapter demonstrates the rationale and current status of nucleic acid-based strategies for treating Huntington’s disease and Parkinson’s disease.

In the second chapter, Marcos Arturo Martínez Banaclocha discusses the current pharmacological interventions available for treating neurodegenerative diseases and brain aging. The author highlights the role of oxidised proteins at the cysteine residues in some neurodegenerative diseases and in aging.

Kazuo Abe focuses on non-motor symptoms in Parkinson’s disease along with the pharmacological therapies to tackle the disease in the third chapter. In the fourth chapter, Anderson and Maes discuss melatonin interactions with the a7nAChR. In the last chapter of this eBook, Norman discusses another important disease of the Central Nervous System i.e. Major Depressive Disorder. The author highlights the pharmacological properties of some novel drugs and evaluates their efficacy critically.

I would like to thank all the contributors for their work and cooperation and would also like to appreciate all the technical staff of Bentham Science Publishers, especially, Mr. Mahmood Alam (Director Publications), Mr. Shehzad Naqvi (Senior Manager Publications) and Dr. Faryal Sami (Assistant Manager Publications) for their hard work and dedication.

Atta-ur-Rahman, FRS
Kings College
University of Cambridge
Cambridge
UK

List of Contributors

Editor(s):
Atta-ur-Rahman FRS
Honorary Life Fellow, Kings College
University of Cambridge
UK




Contributor(s):
Carla Emiliani
Department of Chemistry
Biology and Biotechnology
University of Perugia
Italy


George Anderson
CRC Scotland & London
Eccleston Square
London
UK


Kazuo Abe
Department of Community Health Medicine
Graduate School of Hyogo College of Medicine
Division of Neurology
Hospital of Hyogo College of Medicine
1-1 Mukogawa-Cho, Nishinomiya-City
Hyogo 663-8131
Japan


Marcos Arturo Martínez Banaclocha
Pathology Service at the Lluis Alcanyis Hospital
Játiva
Valencia
Spain


Maria Rita Micheli
Department of Chemistry
Biology and Biotechnology
University of Perugia
Italy


Mario Polidoro
Department of Chemistry
Biology and Biotechnology
University of Perugia
Italy


Michael Maes
Deakin University
Department of Psychiatry
Geelong
Australia


Rodolfo Bova
Department of Chemistry
Biology and Biotechnology
University of Perugia
Italy


Trevor R. Norman
Department of Psychiatry
University of Melbourne
Austin Hospital
Heidelberg
Australia




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