Frontiers in Clinical Drug Research - HIV

Volume 3

by

Atta-ur-Rahman

DOI: 10.2174/97816810822951160301
eISBN: 978-1-68108-229-5, 2016
ISBN: 978-1-68108-230-1
ISSN: 2468-0397 (Print)
ISSN: 2352-5916 (Online)



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Frontiers in Clinical Drug Research – HIV is an eBook series that brings updated...[view complete introduction]

Table of Contents

Preface

- Pp. i

Atta-ur-Rahman

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List of Contributors

- Pp. ii

Atta-ur-Rahman

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Human Papillomavirus in HIV Positive People

- Pp. 3-48 (46)

Anna Rosa Garbuglia

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Allosteric Integrase Inhibitors

- Pp. 49-126 (78)

Victoria Hann, Peter Dawson and Mark Ashton

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HAART: A Boon to Mankind

- Pp. 127-162 (36)

Silpi Basak

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The Current Progress and Challenge in the Development of Entry Inhibitors of HIV-1

- Pp. 163-184 (22)

Chang Liu and Xiaohong Kong

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Prospects of Reverse Transcriptase Inhibitors

- Pp. 185-209 (25)

Chang Liu and Xiaohong Kong

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HIV-1 Integrase Inhibitors: Targets and Clinical Application

- Pp. 210-237 (28)

Chang Liu and Xiaohong Kong

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The Current Progress and Challenge in the Development of Protease Inhibitors of HIV-1

- Pp. 238-264 (27)

Chang Liu and Xiaohong Kong

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Blocking HIV-1 Replication via Targeting the Tatmediated Transcriptional Machinery

- Pp. 265-285 (21)

Chang Liu and Xiaohong Kong

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Subject Index

- Pp. 286-295 (10)

Atta-ur-Rahman

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Preface

The book series, “Frontiers in Clinical Drug Research-HIV” presents important recent developments in the form of cutting edge reviews written by the authorities in the field. The chapters in this 3rd volume are mainly focused on Human papillomavirus (HPV) infections, different HIV-1 inhibitors (integrase inhibitors, protease inhibitors, entry inhibitors and reverse transcriptase inhibitors), Highly Active Antiretroviral Therapy (HAART) and blockage of HIV-1 replication.

Anna Rosa Garbuglia in Chapter 1 discusses a common sexually transmitted disease, Human papillomavirus (HPV) infection that leads to about 250,000 deaths each year. Ashton et al., in chapter 2 discuss the structure, function and mechanism of HIV-1 integrase inhibitors. Highly active antiretroviral therapy (HAART) uses multiple drugs that can act on special viral targets. Chapter 3 by Silpi Basak describes the importance of this therapy that stops the replication of HIV and reduces HIV related deaths, illness and hospitalization by 60-80%.

Chapters 4 to 8 by Liu & Kong provide novel insights into the design of individual anti-HIV strategies on treatments and minimizing side effects for clinical development. These chapters include current progress and challenges in the development of entry inhibitors, prospects of reverse transcriptase inhibitors, targets and clinical applications of integrase inhibitors, outlook of proteinase inhibitors and blocking HIV-1 replication by targeting the Tat-hijacked transcriptional machinery.

I am grateful to all the eminent scientists for their excellent contributions. I also express my gratitude to the editorial staff, particularly Mr. Mahmood Alam (Director Publication), Mr. Shehzad Naqvi (Senior Manager Publications) and Ms. Fariya Zulfiqar (Assistant Manager Publications) for their hard work and persistent efforts.

Prof. Atta-ur-Rahman, FRS
Kings College
University of Cambridge
Cambridge
UK

List of Contributors

Editor(s):
Atta-ur-Rahman
Kings College
University of Cambridge
Cambridge
UK




Contributor(s):
Anna Rosa Garbuglia
Laboratory of Virology
National Institute for Infectious Diseases
Lazzaro Spallanzani - Rome
Italy


Chang Liu
School of Medicine, Center for AIDS
Nankai University, 94Weijin Rd,Nankai District
Tianjin
China


Mark Ashton
Department of Pharmacy, Health and Wellbeing
University of Sunderland
Sunderland, Tyne and Wear
UK


Peter Dawson
Department of Pharmacy, Health and Wellbeing
University of Sunderland
Sunderland, Tyne and Wear
UK


Silpi Basak
Jawaharlal Nehru Medical College
Wardha (MS)
India


Victoria Hann
Department of Pharmacy, Health and Wellbeing
University of Sunderland
Sunderland, Tyne and Wear
UK


Xiaohong Kong
School of Medicine, Center for AIDS
Nankai University, 94Weijin Rd,Nankai District
Tianjin
China




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