Frontiers in Clinical Drug Research - Alzheimer Disorders

Volume 5

by

Atta-ur-Rahman

DOI: 10.2174/97816810823181160501
eISBN: 978-1-68108-231-8, 2016
ISBN: 978-1-68108-232-5
ISSN: 2451-8743 (Print)
ISSN: 2214-5168 (Online)



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Frontiers in Clinical Drug Research - Alzheimer Disorders is an e-Book series w...[view complete introduction]

Table of Contents

Preface

- Pp. i-ii (2)

Atta-ur-Rahman

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List of Contributors

- Pp. iii-iv (2)

Atta-ur-Rahman

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Should Physicians Screen for Dementia in the Primary Care Setting?

- Pp. 3-40 (38)

Paul David Dash

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Endothelial Dysfunction and Chronic Low-Grade Inflammation as Potential Therapeutic Targets in Dementia Disorders

- Pp. 41-82 (42)

Asija Zaciragic, Nesina Avdagic, Nermina Babic, Amela Devisevic, Amina Valjevac, Almir Fajkic, Jasminko Huskic, Almira Hadzovic-Dzuvo and Orhan Lepara

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Recent Clinical Developments in Alzheimer’s Disease

- Pp. 83-143 (61)

Xin Yi Choo and Alexandra Grubman

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Recent Perspective About the Amyloid Cascade Hypothesis and Stem Cell-Based Therapy in the Treatment of Alzheimer's Disease

- Pp. 144-174 (31)

Hany E. Marei, Asmaa Althani, Jaana Suhonen, Mohamed E. El Zowalaty, Mohammad A. Albanna, Carlo Cenciarelli, Tengfei Wang and Thomas Caceci

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Current Concepts in Management of Alzheimer's Disease

- Pp. 175-213 (39)

Vida Demarin, Zlatko Trkanjec, Marijana Bosnar Puretić, Sandra Morović and Anton Glasnović

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Natural Compounds from Plants Targeting Alzheimer’s Disease

- Pp. 214-302 (89)

Andreia Corciova, Daniela Matei, Calin Corciova and Bianca Ivănescu

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Subject Index

- Pp. 303-316 (14)

Atta-ur-Rahman

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Preface

The book series, “Frontiers in Clinical Drug Research – Alzheimer Disorders” presents some important advancements in the field in the form of cutting edge reviews written by eminent experts.

Chapter 1 by Paul David Dash discusses the significant impact of cognitive impairment on a number of clinical matters. The author briefly explains the pros and cons of some of the numerous cognitive screens that can be utilized for screening purposes.

Chapter 2 Zaciragic et al. discuss the detrimental vascular changes that lead to consequent amyloid- β accumulation. This in turn leads to dementia. Moreover it provides a comprehensive insight into currently available evidence on molecular pathways and factors implicated in the above mechanisms. The findings from ongoing clinical trials and results from studies using novel pharmacological approaches to target endothelial dysfunction and chronic low-grade inflammation as pathophysiological events that contribute to the onset and development of dementia disorders are summarized.

Choo & Grubman in chapter 3 present an update on the prevailing mechanistic hypotheses, to explain AD pathogenesis, including the cholinergic, amyloid-cascade, inflammatory and metal dyshomeostasis theories. They present the recent clinical developments in therapies targeting each of the hypotheses, and highlight promising areas requiring further attention.

In Chapter 4, Mareii et al. highlight the recent thinking against the long standing amyloid cascade hypothesis as well as the major efforts in the experimental application of stem cell based therapies used as treatment options for AD. Demarin et al., in Chapter 5 emphasize on the early disease detection and delaying cognitive impairment via various lifestyle modifications.

In chapter 6, Matei et al. present the methods of extraction, identification and quantification of the active compounds from various vegetal products e.g. curcuminoids, ellagic acid, gallic acid, salvianolic acid B, resveratrol and epicagallocatechin-3-gallate that can target the causative agent of Alzheimer’s disease.

The 5th volume of this book series represents the results of a huge amount of work by many eminent researchers. I am grateful to the authors for their excellent contributions. I would also like to express my gratitude to the editorial staff of Bentham Science Publishers, particularly Mr. Mahmood Alam (Director Publication), Mr. Shehzad Naqvi (Senior Manager Publications) and Ms. Fariya Zulfiqar (Assistant Manager Publications) for their hard work and persistent efforts.

Atta-ur-Rahman, FRS
Kings College
University of Cambridge
Cambridge
UK

List of Contributors

Editor(s):
Atta-ur-Rahman FRS
Kings College, University of Cambridge
Cambridge
UK




Contributor(s):
Alexandra Grubman
Department of Pathology
The University of Melbourne
Victoria
Australia


Almir Fajkic
Department of Pathophysiology
Medical Faculty University of Sarajevo
Sarajevo
Bosnia and Herzegovina


Almira Hadzovic-Dzuvo
Department of Human Physiology
Medical Faculty University of Sarajevo
Sarajevo
Bosnia and Herzegovina


Amela Devisevic
Department of Human Physiology
Medical Faculty University of Sarajevo
Sarajevo
Bosnia and Herzegovina


Amina Valjevac
Department of Human Physiology
Medical Faculty University of Sarajevo
Sarajevo
Bosnia and Herzegovina


Andreia Corciova
Department of Drugs Analysis, Faculty of Pharmacy
“Grigore T. Popa” University of Medicine and Pharmacy
Iasi
Romania


Anton Glasnović
Zagreb University School of Medicine
Zagreb
Croatia


Asija Zaciragic
Department of Human Physiology
Medical Faculty University of Sarajevo
Sarajevo
Bosnia and Herzegovina


Asmaa Althani
Biomedical Research Center
Qatar University
Doha, 2731
Qatar
/
Department of Health Sciences, College of Arts and Science
Qatar University
Doha, 2731
Qatar


Bianca Ivănescu
Department of Pharmaceutical Botany, Faculty of Pharmacy
“Grigore T. Popa” University of Medicine and Pharmacy
Iasi
Romania


Calin Corciova
Department of Biomedical Sciences, Faculty of Biomedical Engineering
“Grigore T. Popa” University of Medicine and Pharmacy
Iasi
Romania


Carlo Cenciarelli
CNR-Institute of Translational Pharmacology
Via Fosso del Cavaliere
100-00133 Roma
Italy


Daniela Matei
Department of Biomedical Sciences, Faculty of Biomedical Engineering
“Grigore T. Popa” University of Medicine and Pharmacy
Iasi
Romania


Hany E. Marei
Biomedical Research Center
Qatar University
Doha, 2731
Qatar


Jaana Suhonen
Neurology Department
Al-Ahli Hospital
6401 Doha
Qatar


Jasminko Huskic
Department of Human Physiology
Medical Faculty University of Sarajevo
Sarajevo
Bosnia and Herzegovina


Marijana Bosnar Puretić
University Department of Neurology
Sestre milosrdnice University Hospital Centre
Zagreb
Croatia


Mohamed E. El Zowalaty
Biomedical Research Center
Qatar University
Doha, 2731
Qatar


Mohammad A. Albanna
Psychiatry Department
Hamad Medical Corporation
3050 Doha
Qatar


Nermina Babic
Department of Human Physiology
Medical Faculty University of Sarajevo
Sarajevo
Bosnia and Herzegovina


Nesina Avdagic
Department of Human Physiology
Medical Faculty University of Sarajevo
Sarajevo
Bosnia and Herzegovina


Orhan Lepara
Department of Human Physiology
Medical Faculty University of Sarajevo
Sarajevo
Bosnia and Herzegovina


Paul David Dash
Department of Neurology, Johns Hopkins Bayview Memory and Alzheimer Treatment Center
Johns Hopkins University
Baltimore
USA


Sandra Morović
“Aviva” Medical Centre
Zagreb
Croatia


Tengfei Wang
Department of Pharmacology
University of Tennessee Health Science Center
Memphis
Tennessee


Thomas Caceci
Department of Biomedical Sciences, Virginia-Maryland Regional College of Veterinary Medicine
Virginia Polytechnic Institute and State University
Blacksburg
Virginia


Vida Demarin
Croatian Academy of Sciences and Arts
Zagreb
Croatia


Xin Yi Choo
Department of Pathology
The University of Melbourne
Victoria
Australia


Zlatko Trkanjec
University Department of Neurology
Sestre milosrdnice University Hospital Centre
Zagreb
Croatia




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