Frontiers in Anti-Infective Drug Discovery

Volume 5

by

Atta-ur-Rahman , M. Iqbal Choudhary

DOI: 10.2174/97816810829121170501
eISBN: 978-1-68108-291-2, 2017
ISBN: 978-1-68108-292-9
ISSN: 2451-9162 (Print)
ISSN: 1879-663X (Online)



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This eBook series brings updated reviews to readers interested in advances in the development of anti-infective drug design and discov...[view complete introduction]

Table of Contents

Preface

- Pp. i-ii (2)

Atta-ur Rahman and M. Iqbal Choudhary

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List of Contributors

- Pp. iii-iv (2)

Atta-ur Rahman and M. Iqbal Choudhary

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Virus Infection Pathway in Living Cell: Anomalous Diffusion, Exponent Fluctuations, and Time-Scale Separation

- Pp. 3-22 (20)

Yuichi Itto

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The Antimicrobial Activity of Essential Oils Against Multi-Drug-Resistance Microorganisms: A Review

- Pp. 23-54 (32)

Pio Maria Furneri, Virginia Fuochi, Edmondo Lissandrello, Giulio Petronio Petroniox, Petronio Petronio, Massimo Fresta and Donatella Paolino

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Natural Antimicrobials in Food Processing: Bacteriocins, Peptides and Chitooligosaccharides

- Pp. 55-108 (54)

Eduardo M. Del Aguila, Laidson P. Gomes, Cyntia S. Freitas, Patricia R. Pereira and Vânia F. Paschoalin

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Bacterial Resistance Mechanisms and Inhibitors of Multidrug Efflux Pumps Belonging to the Major Facilitator Superfamily of Solute Transport Systems

- Pp. 109-131 (23)

Manuel F. Varela, Jody L. Andersen, K.C. Ranjana, Sanath Kumar, Leslie M. Sanford and Alberto J. Hernandez

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Medicinal Plants as Immune Response Enhancers to Prevent Infectious Diseases of Veterinary Interest

- Pp. 132-149 (18)

Laura Noelia Cariddi, Ivana Dalila Montironi and Elina Beatriz Reinoso

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In Silico Approaches for Determination of Drug Targets

- Pp. 150-193 (44)

Nikita Chordia and Anil Kumar

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Subject Index

- Pp. 194-200 (7)

Atta-ur Rahman and M. Iqbal Choudhary

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Preface

Infections caused by microorganisms, viruses, and parasites are among the most important challenges faced by the human race. The UN global conference on anti-microbial resistance in 2015 highlighted the need of a global response to tackle epidemics, and emerging drug resistance. The Ebola outbreak of 2013 in West Africa resulting in a heavy death toll, exposed the weaknesses in the current global healthcare systems. Unfortunately, despite tremendous human sufferings as well as the enduring threats to human survival due to infections, the efforts of the pharmaceutical sector toward the development of new anti-infectious agents are less than adequate. Global healthcare research on infections is largely financed by the public funds, which are decreasing world over. This situation demands urgent attention of all stakeholders.

The 5th volume of the book series entitled, “Frontiers in Anti-infective Drug Discovery”, comprises six reviews focussing on three broad fields i.e. molecular mechanism of infections and target identification for drug discovery and development, the use of various natural agents and their derivatives against various infections in humans and livestock, and the use of natural antimicrobial agents in food processing. These articles are contributed by leading practitioners in this field.

Yuichi Itto has contributed a comprehensive review of the recent literature on the physics of diffusion of viruses in the cytoplasm of livings cells. The aim was to present a kinetic theory for the infection pathways of viruses in the cytoplasm of cells. The review by Furneri et al. is focused on the antimicrobial activities of essential oils of various medicinal and aromatic plants, especially against multi-drug resistance bacteria. Del Aguila et a.l have contributed a comprehensive chapter on bioactive proteins and peptides derived from food matrices, or released from microorganisms. This review described the antimicrobial properties of various protein and peptides in polymeric food matrices.

Varela et a.l reviewed the recent literature on the studies of various efflux pump protein super-families which play a key role in multi-drug resistance (MDR) in bacteria. MDR bacteria pose a major challenge in the treatment of infectious diseases. Understanding the underlying mechanism of drug resistance is the key to develop new therapies. The next chapter by Cariddi et a.l is focused on an important aspect of infectious disease prevention and treatment. This involves the use of plant based products in boosting natural defence against infections in livestock. The extensive use of antibiotics in cattle is associated with the emergence of antibiotic resistance and the release of antibiotic residues in dairy and meat products. The review emphasizes on the importance of reinforcing the natural defence against infections by using medicinal plant extracts as well as pure phytochemicals, thus decreasing the reliance and use of antibiotics. In the last chapter, Chordia and Kumar contributed an excellent review on the applications of bioinformatics, computational biology and computational chemistry in the identification of new drug target(s) in pathogenic microorganisms. These drug targets can be enzymes, receptors, ion channels and nucleic acids.

In brief, the above cited reviews contributed by leading researchers in the field make this volume an interesting and useful reading for research scientists and graduate students. We wish to express our gratitude to all the authors for their excellent and scholarly contributions for the 5th volume of this reputed eBook series. We also greatly appreciate the efforts of the entire team of Bentham Science Publishers for efficient processing and timely management of publication. The skills and efforts of Ms. Fariya Zulfiqar (Assistant Manager Publications), and leadership of Mr. Shehzad Naqvi (Senior Manager Publications) & Mr. Mahmood Alam (Director Publications) are especially praiseworthy. We also hope that like the previous volumes of this internationally recognized book series, the current compilation will also receive a wide readership and appreciation.

Atta-ur-Rahman, FRS
Kings College
University of Cambridge
UK

&

M. Iqbal Choudhary
H.E.J. Research Institute of Chemistry
International Center for Chemical and Biological Sciences
University of Karachi
Pakistan

List of Contributors

Editor(s):
Atta-ur-Rahman
University of Cambridge
Kings College
Cambridge
UK


M. Iqbal Choudhary
H.E.J. Research Institute of Chemistry
University of Karachi
Karachi, 75270
Pakistan




Contributor(s):
Alberto J. Hernandez
Department of Biology
Eastern New Mexico University
Portales, NM 88130
USA


Anil Kumar
School of Biotechnology
Devi Ahilya University, Takshashila Campus, Khandwa Road
INDORE-452001
India


Cyntia S. Freitas
Universidade Federal do Rio de Janeiro, Instituto de Qumica
Av. Athos da Silveira Ramos 149 - Cidade Universitária, 21949-909
Rio de Janeiro - RJ
Brazil


Donatella Paolino
Dipartimento di Medicina Sperimentale e Clinica
Università degli Studi "Magna Graecia" di Catanzaro - Campus "Salvatore Venuta"
Viale Europa I- 88100
Italy


Edmondo Lissandrello
Dipartimento di Scienze Biomediche e Biotecnologiche BIOMETEC, Sezione di Microbiologia
Università degli Studi di Catania
Catania
Italy


Eduardo M. Del Aguila
Universidade Federal do Rio de Janeiro, Instituto de Qumica
Av. Athos da Silveira Ramos 149 - Cidade Universitária, 21949-909
Rio de Janeiro - RJ
Brazil


Elina Beatriz Reinoso
Departamento de Microbiología e Inmunología
Universidad Nacional de Río Cuarto, Argentina- Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET)
Córdoba
Argentina


Giulio Petronio Petronio
Dipartimento di Scienze Biomediche e Biotecnologiche BIOMETEC, Sezione di Microbiologia
Università degli Studi di Catania
Catania
Italy
/
IRCCS San Raffaele Pisana
BioBIM - Multidisciplinary Interinstitutional BioBank
Roma
Italy


Ivana Dalila Montironi
Departamento de Microbiología e Inmunología
Universidad Nacional de Río Cuarto, Argentina- Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET)
Córdoba
Argentina


Jody L. Andersen
Department of Biology
Eastern New Mexico University
Portales, NM 88130
USA


Laidson P. Gomes
Universidade Federal do Rio de Janeiro, Instituto de Qumica
Av. Athos da Silveira Ramos 149 - Cidade Universitária, 21949-909
Rio de Janeiro - RJ
Brazil


Laura Noelia Cariddi
Departamento de Microbiología e Inmunología
Universidad Nacional de Río Cuarto, Argentina- Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET)
Córdoba
Argentina


Leslie M. Sanford
Department of Biology
Eastern New Mexico University
Portales, NM 88130
USA


Manuel F. Varela
Department of Biology
Eastern New Mexico University
Portales, NM 88130
USA


Massimo Fresta
Dipartimento di Scienze della Salute
Università degli Studi "Magna Graecia" di Catanzaro - Campus "Salvatore Venuta"
Viale Europa I- 88100
Italy


Nikita Chordia
School of Biotechnology
Devi Ahilya University, Takshashila Campus, Khandwa Road
INDORE-452001
India


Patricia R. Pereira
Universidade Federal do Rio de Janeiro, Instituto de Qumica
Av. Athos da Silveira Ramos 149 - Cidade Universitária, 21949-909
Rio de Janeiro - RJ
Brazil


Pio Maria Furneri
Dipartimento di Scienze Biomediche e Biotecnologiche BIOMETEC, Sezione di Microbiologia
Università degli Studi di Catania
Catania
Italy


K.C. Ranjana
Department of Biology
Eastern New Mexico University
Portales, NM 88130
USA


Sanath Kumar
QC Laboratory, Harvest and Post-Harvest Technology Division
Central Institute of Fisheries Education (CIFE), Seven Bungalows, Versova, Andheri (W)
Mumbai 400061
India


Vânia F. Paschoalin
Universidade Federal do Rio de Janeiro, Instituto de Qumica
Av. Athos da Silveira Ramos 149 - Cidade Universitária, 21949-909
Rio de Janeiro - RJ
Brazil


Virginia Fuochi
Dipartimento di Scienze Biomediche e Biotecnologiche BIOMETEC, Sezione di Microbiologia
Università degli Studi di Catania
Catania
Italy


Yuichi Itto
Science Division, Center for General Education
Aichi Institute of Technology
Aichi 470-0392
Japan




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