Antiprotozoal Drug Discovery: A Challenge That Remains


by

Norma Rivera

DOI: 10.2174/97816810832921160101
eISBN: 978-1-68108-329-2, 2016
ISBN: 978-1-68108-330-8



Recommend this eBook to your Library

Indexed in: EBSCO.

Protozoan infections that are endemic in countries with limited economic resources pose a significant public health challenge to affec...[view complete introduction]

Table of Contents

Foreword

- Pp. i

Filiberto Malagón

Download Free

Preface

- Pp. ii

Norma Rivera

Download Free

List of Contributors

- Pp. iii-iv (2)

Norma Rivera

Download Free

Protozoal Diseases: Importance and Prophylaxis

- Pp. 3-40 (38)

Filiberto Malagón and Elba Carrasco

View Abstract Purchase Chapter

Drugs for Parasitic Diseases - Strategies to Solve a Global Problem

- Pp. 41-65 (25)

A. Valeria Pozzoli and Miriam A. Martins Alho

View Abstract Purchase Chapter

Crude Extracts and Isolated Compounds with Trypanocidal Activity

- Pp. 66-91 (26)

Paz M. Salazar Schettino, Gloria Rojas, Margarita Cabrera and Martha Bucio

View Abstract Purchase Chapter

Malaria, Generalities and New Treatments

- Pp. 92-105 (14)

Luz Eugenia Alcántara-Quintana, Mónica Salas-Rojas and Emmanuelle Alvarado-Alvarez

View Abstract Purchase Chapter

Update on Advances in Plant-based Antimalarial Drug Discovery

- Pp. 106-155 (50)

Pius S. Fasinu, Ilias Muhammad and Larry A. Walker

View Abstract Purchase Chapter

Metals as an Option for Protozoa Treatment

- Pp. 156-179 (24)

Norma Rivera, Marcela Rojas-Lemus, Gumaro Cano-Gutierrez, Luis F. Montaño and Teresa I. Fortoul

View Abstract Purchase Chapter

Subject Index

- Pp. 180-189 (10)

Norma Rivera

Download Free

Foreword

Low-income populations in developing regions of Africa, Asia and the Americas have been particularly injured by a group of tropical infections denominated neglected diseases. Comparative to important illnesses, neglected diseases do not enjoy significant research funding and are not considerably important targets for the “Big Pharma” in terms of development of new drugs, though these infections can make widespread diseases like AIDS more deadly. Although the known preventive measures or acute medical treatments for some of these diseases, the fact of being especially endemic in poorer areas claims for attention. This eBook is devoted to inspire those who are dealing with drug development to make an effort towards combating neglected diseases.

In this line, this eBook is directed towards anyone who is interested in or deals with medicinal chemistry focused on neglected diseases, from students to advanced researchers. Despite affecting millions of people around the world, causing many deaths and having a great and limiting influence on the life quality, the selection of new molecular targets and the development of more efficient drugs against those diseases are scarce. Furthermore, surprisingly little detailed computational work on this subject has appeared. However, it should be kept in mind that computers are an essential tool in modern medicinal chemistry. Nowadays, computational approaches and 3D visualization are not used simply to depict pretty pictures of molecules in biological systems; these powerful computational tools allow one to obtain insights on the interaction between enzyme-substrate, reaction mechanisms, statistical behavior of molecules and much more, at the molecular level, contributing significantly to solve problems in biological systems. In this context, the study of chemoinformatics is crucial. This new field of science was officially introduced at the end of the last century and it can be defined as “the application of computer to a range of problems in the field of chemistry”.

This eBook hereby attempts to explore an open problem in the literature with a stimulating discussion on the state of the art knowledge in this important research field – neglected diseases – pointing out perspectives on using molecular modeling and theoretical approaches. Therefore, 9 chapters were selected containing the participation of different international experts on the subject. We hope that this eBook can play an attractive role for chemists, physicists and biologists in promoting the diffusion of knowledge in the field of chemoinformatics applied to neglected diseases.

Filiberto Malagón
Laboratory of Malariology
Department of Microbiology and Parasitology
Faculty of Medicine
UNAM
Mexico


Preface

Protozoan parasites are a worldwide public health problem that challenge the immune system of millions of humans and non-humans animals, resulting in devastating social and economic consequences. Until now, chemotherapy is central to the control of most of the infections caused by these parasites in both medical and veterinary practice. Chemotherapy control, has been mainly compromised by the development of parasite drug resistance, drugs severe side-effects and toxicity, low to medium efficacy, high cost drugs, and the introduction of counterfeit drugs that are a threat to public health with many overwhelming effects for patients; consequently, the search for new antiprotozoan drugs is an urgent need.

The development of new drugs against these parasites, has been largely neglected because they mainly affect people living in extreme poverty with limited or non-marketing possibilities; for these reasons, in some endemic countries, herbal medicine has become an important and sustainable source of control.

This eBook is an effort of researches who work in the field of antiparasitic experimental chemotherapy and medical parasitology and it summarizes the progresses made in the field of chemotherapy and drug research against protozoan diseases. Synthetic and natural treatments to control Chagas disease, malaria, toxoplasmosis and other parasitic diseases, are discussed in order to open the possibility for applying these scientific progress in the field of antiprotozoan chemotherapy.

The editor and the authors would like to thank Bentham Science Publishers for providing the opportunity to bring this knowledge to the scientific community and to the general public.

Norma Rivera
Laboratory of Malariology
Department of Microbiology and Parasitology
Faculty of Medicine
UNAM
Mexico

List of Contributors

Editor(s):
Norma Rivera
Laboratory of Malariology
Department of Microbiology and Parasitology
Faculty of Medicine
UNAM
Mexico




Contributor(s):
A. Valeria Pozzoli
LabMOr-INTECIN, Departamento de Química de la Facultad de Ingeniería
de la Universidad de Buenos Aires
Ciudad Autónoma de Buenos Aires
Argentina


Elba Carrasco
Laboratory of Malariology, Department of Microbiology and Parasitology, Faculty of Medicine
National Autonomous University of Mexico (UNAM)
Mexico City, 04510
Mexico


Emmanuelle Alvarado-Alvarez
Centre for Science and Technology Studies 14, Luis Enrique Erro
National Polytechnic Institute
Michoacana, Venustiano Carranza, AP. 15240
Mexico City
Mexico


Filiberto Malagón
Laboratory of Malariology, Department of Microbiology and Parasitology, Faculty of Medicine
National Autonomous University of Mexico (UNAM)
Mexico City, 04510
Mexico


Gloria Rojas
Laboratorio de Biología de Parásitos, Departamento de Microbiología y Parasitología, Facultad de Medicina
Universidad Nacional Autónoma de México
México City, 04510
México


Gumaro Cano-Gutierrez
School of Health Sciences
UVM, Campus Sur
Mexico City
Mexico


Luz Eugenia Alcántara-Quintana
Potosino Institute for Scientific Research
Road to San José Dam 4th 2055. AP. 78216
San Luis Potosí
Mexico


Larry A. Walker
National Center for Natural Products Research
University of Mississippi
University MS, 38677
USA
/
Department of BioMolecular Sciences, Research Institute of Pharmaceutical Sciences
University of Mississippi
University MS, 38677
USA


Luis F. Montaño
Department of Cellular and Tissue Biology, Faculty of Medicine
National Autonomous University of Mexico
Mexico City, 04510
Mexico


Margarita Cabrera
Laboratorio de Biología de Parásitos, Departamento de Microbiología y Parasitología, Facultad de Medicina
Universidad Nacional Autónoma de México
México City, 04510
México


Marcela Rojas-Lemus
Department of Cellular and Tissue Biology, Faculty of Medicine
National Autonomous University of Mexico
Mexico City, 04510
Mexico


Martha Bucio
Laboratorio de Biología de Parásitos, Departamento de Microbiología y Parasitología, Facultad de Medicina
Universidad Nacional Autónoma de México
México City, 04510
México


Miriam A. Martins Alho
LabMOr-INTECIN, Departamento de Química de la Facultad de Ingeniería
de la Universidad de Buenos Aires
Ciudad Autónoma de Buenos Aires
Argentina


Mónica Salas-Rojas
National Medical Center, XXI Century
Mexican Social Security Institute. Doctores 330
Cuauhtémoc, AP. 06725
Mexico City


Norma Rivera
Laboratory of Malariology, Department of Microbiology and Parasitology, Faculty of Medicine
National Autonomous University of Mexico
Mexico City, 04510
Mexico


Paz M. Salazar Schettino
Laboratorio de Biología de Parásitos, Departamento de Microbiología y Parasitología, Facultad de Medicina
Universidad Nacional Autónoma de México
México City, 04510
México


Pius S. Fasinu
National Center for Natural Products Research
University of Mississippi
University MS, 38677
USA


Teresa I. Fortoul
Department of Cellular and Tissue Biology, Faculty of Medicine
National Autonomous University of Mexico
Mexico City, 04510
Mexico




Advertisement


Related Journals



Related Books



Webmaster Contact: info@benthamscience.org Copyright © 2017 Bentham Science