Physical Penetration Enhancers: Therapeutic Applications and Devices

Book Series: Current Technologies to Increase the Transdermal Delivery of Drugs

Volume 2

by

José Juan Escobar-Chávez

DOI: 10.2174/97816810836361160201
eISBN: 978-1-68108-363-6, 2016
ISBN: 978-1-68108-364-3
ISSN: 2468-7375 (Print)
ISSN: 2468-7383 (Online)



Recommend this eBook to your Library



This volume covers the methods of using skin penetrating agents, the therapeutic applications of physical penetration enhancers and de...[view complete introduction]

Table of Contents

Foreword

- Pp. i-ii (2)

Amparo Nácher Alonso

Download Free

Special Acknowledgements

- Pp. iii

José Juan Escobar-Chávez

Download Free

Preface

- Pp. iv-v (2)

José Juan Escobar-Chávez

Download Free

List of Contributors

- Pp. vi-vii (2)

José Juan Escobar-Chávez

Download Free

Physical Penetration Enhancers: An Overview

- Pp. 3-34 (32)

Isabel Marlen Rodríguez-Cruz, Clara Luisa Domínguez-Delgado, José Juan Escobar-Chávez, Miriam López-Cervantes and Roberto Díaz-Torres

View Abstract Purchase Chapter

Iontophoresis

- Pp. 35-67 (33)

María Aracely Calatayud-Pascual, Cristina Balaguer-Fernández, Alicia López-Castellano and Virginia Merino

View Abstract Purchase Chapter

Delivery of DNA-Based Vaccines with In Vivo Electroporation

- Pp. 68-100 (33)

Trevor R.F. Smith, Katherine Schultheis and Kate E. Broderick

View Abstract Purchase Chapter

Sonophoresis: Therapeutical Uses and Devices

- Pp. 101-149 (49)

José Juan Escobar-Chávez, Pablo Serrano Castañeda, Omar Rodrigo Guadarrama-Escobar, Alma Lidia Aguiñaga-Mireles, Miriam López- Cervantes, Clara Luisa Domínguez-Delgado and Jessica Martínez-Hernández

View Abstract Purchase Chapter

Radiofrequency as Physical Approach for Transdermal Penetration Enhancement, Non- Surgical Skin Procedures, Orthopedics and Chronic Pain

- Pp. 150-209 (60)

Jennyfer Cázares Delgadillo

View Abstract Purchase Chapter

Microneedles

- Pp. 210-259 (50)

Yunhua Gao, Yuqin Qiu and Suohui Zhang

View Abstract Purchase Chapter

Nanocarrier Systems with the Use of Physical Enhancers

- Pp. 260-314 (55)

Roberto Diaz-Torres, Isabel Marlen Rodríguez-Cruz, Elizabeth García- García, Clara Luisa Domínguez-Delgado and Patricia Ramirez-Noguera

View Abstract Purchase Chapter

Glossary

- Pp. 315

José Juan Escobar-Chávez

Download Free

Subject Index

- Pp. 316-326 (11)

José Juan Escobar-Chávez

Download Free

Foreword

Pharmaceutical knowledge has grown exponentially over the last 40 years. We now have a much clearer understanding of how drugs are absorbed into, distributed within, and cleared from the body.

The potency of agents with which we deal continues to increase, and our ability to unravel mechanisms of action proceeds. New drugs –in particular peptides, proteins and other biological response modifiers- are being developed and new challenges await pharmaceutical scientists. Controlled drug delivery represents a field that must keep pace with changing nature of chemotherapy. Tighter control of drug input into the body in both quantitative and temporal senses is crucial, and design of new delivery systems must respond to this demand for increased sophistication. For this purpose, scientists have used new technologies to improve the penetration rate of drugs. These technologies include physical and electrical methods that include iontophoresis (small direct current), sonophoresis (mainly by low frequency ultrasound energy), electroporation (by application of short micro to milli-second electrical pulses), radiofrequency (laser-generated stress), microneedles and also the use of nanocarriers alone or in combination with the use of the above mentioned physical enhancers. These biophysical techniques have many others therapeutical applications that include physiotherapy, gene delivery, DNA based vaccination, drug administration, diagnosis, dentistry, etc.

The development of technology has permitted the generation of devices that involve the use of physical enhancers for many of the mentioned therapeutical applications.

The objective of this book is to provide a general and an updated overview of the theoretical and practical aspects of iontophoresis, electroporation, sonophoresis, microneedles, radiofrequency and transdermal nanocarrier systems on the delivery of transdermal drugs. Such a generalized approach would be helpful in medicine, pharmacy, drug discovery, drug delivery, drug design and toxicological research.

The contributors to this text have been directed to emphasize updates on above mentioned technologies involved in therapeutic applications and devices. Authors were selected for their knowledge and reputation in their subject area, and for their ability to address objectively the topics of this book. I believe that they have performed this task effectively, producing a text that will facilitate and optimize future developmental programs in pharmacy, medicine and pharmaceutical technology.

Dr. Amparo Nácher Alonso
Department of Pharmacy and Pharmaceutical Technology
University of Valencia,
Spain


Preface

Physical penetration enhancers: Therapeutic applications and devices”, is the second volume of the series “Current technologies to increase the transdermal delivery of drugs” from Bentham Science Publishers. This book provides an overview of main current physical enhancers in the therapeutical and pharmacy field. The importance of therapeutical applications of physical enhancers, and devices existing in the market will be addressed in each chapter. Exclusive chapters on Iontophoresis, Sonophoresis, Electroporation, Microneedles, Radiofrequency and more recently the use of nanoparticles in combination with the above mentioned physical enhancers, highlighting their main therapeutic applications will be included in this book.

Currently, there are no unique books available on therapeutical applications of physical penetration enhancers and currently devices in the market. Brief chapters and books describing only one of the physical enhancers or only one of the therapeutical applications (i.e., transdermal drug delivery) of these enhancers are available to readers in some drug delivery or toxicology books. For these reasons, more detailed information about therapeutical applications (drug delivery, gene therapy, physiotherapy, skin disorders, vaccination, etc.) is now needed. This book presents a general overview of the theoretical and therapeutic aspects of iontophoresis, electroporation, sonophoresis, microneedles, radiofrequency and nanocarriers systems in combination with physical enhancers. Such a generalized approach would be helpful in medicine, pharmacy, drug discovery, drug delivery and toxicological research.

A comprehensive book which provides the basis and updated therapeutical research information is necessary. For this fact, this e-book will be an interesting option that could be used by students and academics of medicine, biopharmacy, pharmaceutical technology, design and development of drugs, pharmacology, by physicians, dermatologists, scientists and pharmaceutical R & Ds. The book also will be useful for medicine, pharmacy, pharmacology and pharmaceutical technology departments of different Universities all over the world.

In summary, this e-book reviews the therapeutical uses of physical enhancers such as iontophoresis, sonophoresis, electroporation, microneedles, radiofrequency and nanocarriers in combination with physical enhancers. After an introduction, definition, mechanisms of action, the focus turns to the relevance of therapeutical applications studies and finally the different physical enhancer devices in the market.

Dr. José Juan Escobar-Chávez
Universidad Nacional Autónoma de México
Facultad de Estudios Superiores Cuautitlán
Unidad de Investigación Multidisciplinaria
Laboratorio 12: Sistemas transdérmicos y materiales nanoestructurados
Av. Cuautitlán-Teoloyucan. San Sebastián Xhala
Cuautitlán Izcalli, Estado de México. C.P 54714,
México

List of Contributors

Editor(s):
Dr. José Juan Escobar-Chávez
Unidad de Investigación Multidisciplinaria
Laboratorio 12: “Sistemas Transdérmicos y Nanomateriales”
Facultad de Estudios Superiores Cuautitlán
Universidad Nacional Autónoma de México
Km 2.5 Carretera Cuautitlán–Teoloyucan
San Sebastián Xhala, Cuautitlán Izcalli
Estado de México
México CP. 54714




Contributor(s):
Alicia López Castellanos
Instituto de Ciencias Biomédicas. Departamento de Farmacia
Facultad de Ciencias de la Salud. Universidad CEU Cardenal Herrera, 46113
Moncada
Spain


Alma Lidia Aguiñaga Mirelles
Unidad de Investigación Multidisciplinaria. Laboratorio 12: “Sistemas Transdérmicos y Nanomateriales”
Facultad de Estudios Superiores Cuautitlán-Universidad Nacional Autónoma de México. Km 2.5 Carretera Cuautitlán–Teoloyucan, San Sebastián Xhala, Cuautitlán Izcalli
Estado de México
México


Clara Luisa Domínguez-Delgado
Unidad de Investigación Multidisciplinaria. Laboratorio 12: “Sistemas Transdérmicos y Nanomateriales”
Facultad de Estudios Superiores Cuautitlán-Universidad Nacional Autónoma de México. Km 2.5 Carretera Cuautitlán–Teoloyucan, San Sebastián Xhala, Cuautitlán Izcalli
Estado de México
México


Cristina Balaguer-Fernández
Instituto de Ciencias Biomédicas
Departamento de Farmacia. Facultad de Ciencias de la Salud. Universidad CEU Cardenal Herrera
46113 Moncada
Spain


Elizabeth García-García
Psicofarma S.A. de C.V., Calz. de Tlalpan 4369, Col
Toriello Guerra
Distrito Federal. C.P.14050
México


Isabel Marlen Rodríguez-Cruz
Hospital Regional de Alta Especialidad Zumpango. Unidad de Enseñanza e Investigación
Carretera Zumpango-Jilotzingo #400. Barrio de Santiago 2da Sección. Zumpango,
Estado de México. C.P. 55600
México


Jennyfer Cázares Delgadillo
R&I, L’Oreal, 188-200 rue Paul-Hochart
94550 Chevilly-Larue
France


José Juan Escobar-Chávez
Unidad de Investigación Multidisciplinaria. Laboratorio 12: “Sistemas Transdérmicos y Nanomateriales”
Facultad de Estudios Superiores Cuautitlán-Universidad Nacional Autónoma de México. Km 2.5 Carretera Cuautitlán–Teoloyucan, San Sebastián Xhala, Cuautitlán Izcalli
Estado de México
México


Kate Broderick
Inovio Pharmaceuticals, Inc., 660W. Germantown Pike, Suite 110
Plymouth Meeting, PA 19462, USA


Katherine Schultheis
Inovio Pharmaceuticals, Inc., 660W. Germantown Pike, Suite 110
Plymouth Meeting, PA 19462, USA


María Araceli Catalayud-Pascual
Instituto de Ciencias Biomédicas. Departamento de Farmacia
Facultad de Ciencias de la Salud. Universidad CEU Cardenal Herrera
46113 Moncada
Spain


Miriam López-Cervantes
Unidad de Investigación Multidisciplinaria. Laboratorio 12: “Sistemas Transdérmicos y Nanomateriales”
Facultad de Estudios Superiores Cuautitlán-Universidad Nacional Autónoma de México. Km 2.5 Carretera Cuautitlán–Teoloyucan, San Sebastián Xhala, Cuautitlán Izcalli
Estado de México
México
/
Laboratorio de Farmacotecnia. Universidad Autónoma Metropolitana-Xochimilco
Calzada del Hueso 1100, Villa Quietud, Coyoacán, Distrito Federal,
México, C.P. 04960
México


Omar Rodrigo Guadarrama-Escobar
Unidad de Investigación Multidisciplinaria. Laboratorio 12: “Sistemas Transdérmicos y Nanomateriales”
Facultad de Estudios Superiores Cuautitlán-Universidad Nacional Autónoma de México. Km 2.5 Carretera Cuautitlán–Teoloyucan, San Sebastián Xhala, Cuautitlán Izcalli
Estado de México
México


Pablo Serrano Castañeda
Unidad de Investigación Multidisciplinaria. Laboratorio 12: “Sistemas Transdérmicos y Nanomateriales”
Facultad de Estudios Superiores Cuautitlán-Universidad Nacional Autónoma de México. Km 2.5 Carretera Cuautitlán–Teoloyucan, San Sebastián Xhala, Cuautitlán Izcalli
Estado de México
México


Patricia Ramírez Noguera
Unidad de Investigación Multidisciplinaria
acultad de Estudios Superiores Cuautitlán, Universidad Nacional Autónoma de México,
Estado de México
México


Roberto Díaz-Torres
Unidad de Investigación Multidisciplinaria
acultad de Estudios Superiores Cuautitlán, Universidad Nacional Autónoma de México,
Estado de México
México


Suohui Zhang
Key Laboratory of Photochemical Conversion and Optoelectronic Materials
Technical Institute of Physics and Chemistry, Chinese Academy of Sciences
Beijing, 100190
China


Trevor RF Smith
Inovio Pharmaceuticals, Inc., 660W
Germantown Pike, Suite 110
Plymouth Meeting, PA 19462, USA



Virginia Merino
Instituto Interuniversitario de Reconocimiento Molecular y Desarrollo Tecnológico, Centro Mixto Universidad Politécnica de Valencia-Universidad de Valencia. Departament de Farmàcia i Tecnologia Farmacèutica
Facultat de Farmacia, Universitat de València
46100 Burjassot
Spain


Yunhua Gao
Key Laboratory of Photochemical Conversion and Optoelectronic Materials
Technical Institute of Physics and Chemistry, Chinese Academy of Sciences
Beijing, 100190
China


Yuqin Qiu
Key Laboratory of Photochemical Conversion and Optoelectronic Materials
Technical Institute of Physics and Chemistry, Chinese Academy of Sciences
Beijing, 100190
China




Advertisement


Related Journals

Related Books

Webmaster Contact: info@benthamscience.org Copyright © 2017 Bentham Science