Molecular and Cellular Biology of Pathogenic Trypanosomatids

Book Series: Frontiers in Parasitology

Volume 1

by

Marcelo Santos da Silva, Maria Isabel N. Cano

DOI: 10.2174/97816810840531170101
eISBN: 978-1-68108-405-3, 2017
ISBN: 978-1-68108-406-0
ISSN: 2542-4211 (Print)
ISSN: 2542-422X (Online)





Every year millions of people living in tropical areas across the globe, are affected by trypanosomatids – the parasites causing Chaga...[view complete introduction]

Virulence Factors and Immune Evasion in Leishmania spp.

- Pp. 291-345 (55)

Jose M. Requena and Manuel Soto

Abstract

Protozoan parasites of the genus Leishmania cause a group of diseases, known as leishmaniasis, affecting humans and also household pets, mainly canids. In the human host, different pathological outcomes ranging from self-healing cutaneous lesions to systemic visceral leishmaniasis are produced by these parasites; these diseases affect millions of people worldwide. Similar to a virus, bacteria and other parasites, Leishmania need to evade immune destruction with the aim of completing their life cycle in their mammalian hosts. Moreover, the long co-evolutionary history between parasites of the genus Leishmania and their hosts for several millions of years has led to a balanced relationship. To avoid the powerful immune system of mammals, the parasite has developed a set of sophisticated mechanisms to persist, replicate, and spread.

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