Frontiers in Stem Cell and Regenerative Medicine Research

Volume 6

by

Prof. Atta-ur-Rahman , Dr. Shazia Anjum

DOI: 10.2174/97816810847701170601
eISBN: 978-1-68108-477-0, 2017
ISBN: 978-1-68108-478-7
ISSN: 2467-9593 (Print)
ISSN: 2352-7633 (Online)



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Stem cell and regenerative medicine research is a hot area of research which promises to change the face of medicine as it will be pra...[view complete introduction]

Table of Contents

Preface

- Pp. i

Atta-ur Rahman and Shazia Anjum

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List of Contributors

- Pp. ii-iv (3)

Atta-ur Rahman and Shazia Anjum

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The Emerging Role of Mesenchymal Stem Cell Secretome in Cartilage Regeneration

- Pp. 1-20 (20)

Wei Seong Toh

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The Potential Clinical Application of Mesenchymal Stem Cells from the Dental Pulp (DPSCs) for Bone Regeneration

- Pp. 21-70 (50)

Ana Rita Caseiro, Rui Alvites, Sílvia Santos Pedrosa, José Miguel Campos, Inês Leal Reis, José Domingos Santos, Carla Mendonça, Luís Miguel Atayde and Ana Colette Maurício

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Mesenchymal Stem Cells in Regenerative Medicine: The Challenges and the Opportunities

- Pp. 71-104 (34)

Chen Kan, Lijun Chen, Yangyang Hu, Haimei Lu and Lixin Kan

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Liver Regeneration: An update on the Role of Non- Parenchymal Cells

- Pp. 105-127 (23)

Beatriz Arteta, Antonia Alvarez, Joana Marquez, Aitor Benedicto and Enrique Hilario

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Cardiogenesis and Repair: Insights from Development and Clinical Trials

- Pp. 128-166 (39)

Sheena Raju, Daniel McCulloch, Alister C. Ward and Chandra Viswanathan

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The Role of Ca2+ Signalling in the Differentiation of Embryonic Stem Cells (ESCs) into Cardiomyocytes

- Pp. 167-187 (21)

Baixia Hao, Wenjie Wei, Sarah E. Webb, Andrew L. Miller and Jianbo Yue

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Regenerative Cell-Based Therapies to Combat Neurodegenerative Disorders

- Pp. 188-205 (18)

Zareen Amtul

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Stem Cell Transplantation: Is this the Future Solution for Parkinson's Disease?

- Pp. 206-240 (35)

José Rubén García- Montes and René Drucker- Colín

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Subject Index

- Pp. 241-250 (10)

Atta-ur Rahman and Shazia Anjum

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Preface

Research in the rapidly emerging field of stem cells is playing a pivotal role in regenerative medicine. The first 3 chapters of this volume deal with mesenchymal stem cell research. In chapter 1, Wei Seong Toh presents the emerging role of mesenchymal stem cell (MSC) secretome as a new paradigm in treating cartilage regeneration. The study of MSC secretome allows a better mechanistic understanding of the role of MSCs in tissue repair and disease treatment.

Mauricio et al. describe a promising strategy for the optimization of hybrid systems through the association of biomaterials to dental pulp stem cells, in chapter 2. Dental pulp stem cells can be easily isolated from deciduous and definitive teeth. In chapter 3, Kan et al. describe the recent progress and the opportunities as well as challenges in MSC research.

Arteta et al., in chapter 4, discuss current studies that underline the importance of liver progenitor cells (LPCs) for constructing bioartificial livers and as the source of cells for transplantation.

In the next chapter, Ward et al. present new exciting developments in cardiogenesis from bench-to-bedside. They review the heart development in different organisms, supplemented with insights from stem cell biology and clinical studies, which will throw light on the development of effective stem cell treatments for myocardial infarction and other cardiac diseases. Yue et al., in their chapter 6, present an overview of different Ca2+ signalling events in the differentiation of embryonic stem cells into cardiomyocytes.

The last two chapters deal with neurodegenerative diseases. Zareen Amtul, in Chapter 7, highlights the regenerative cell-based therapies that can be used to combat neurodegenerative disorders. In the last chapter, García-Montes and Drucker-Colín discuss in detail about the central role of stem cell transplantation to cure Parkinson´s Disease. They discuss the current challenges in optimizing stem cell therapy for the treatment of Parkinson’s disease.

We hope that the readers will enjoy the comprehensive reviews on new developments in stem cell and regenerative medicine research. We wish to thank the editorial staff of Bentham Science Publishers, particularly Dr. Faryal Sami, Mr. Shehzad Naqvi and Mr. Mahmood Alam for their constant help and support.

Prof. Atta-ur-Rahman, FRS
Honorary Life Fellow
Kings College
University of Cambridge
Cambridge
UK

&

Dr. Shazia Anjum
Department of Chemistry
Cholistan Institute of Desert Studies
The Islamia University of Bahawalpur
Pakistan

List of Contributors

Editor(s):
Prof. Atta-ur-Rahman
Honorary Life Fellow
Kings College
University of Cambridge
Cambridge
UK


Dr. Shazia Anjum
Department of Chemistry
Cholistan Institute of Desert Studies
The Islamia University of Bahawalpur
Pakistan




Contributor(s):
Aitor Benedicto
Department Cell Biology and Histology, School of Medicine and Enfermery
University of Basque Country
E-48940 Leioa
Spain


Alister C. Ward
School of Medicine
Deakin University
Geelong
Victoria
Australia
/
Centre for Molecular and Medical Research
Deakin University
Geelong
Victoria
Australia


Ana Colette Maurício
Centro de Estudos de Ciência Animal (CECA), Instituto de Ciências
Tecnologias e Agroambiente (ICETA) da Universidade do Porto, Praça Gomes Teixeira, Apartado 55142, 4051-401
Porto
Portugal
/
Departamento de Clínicas Veterinárias, Instituto de Ciências Biomédicas de Abel Salazar (ICBAS)
Universidade do Porto (UP), Rua de Jorge Viterbo Ferreira, nº 228
4050-313 Porto
Portugal


Ana Rita Caseiro
Centro de Estudos de Ciência Animal (CECA), Instituto de Ciências
Tecnologias e Agroambiente (ICETA) da Universidade do Porto, Praça Gomes Teixeira, Apartado 55142, 4051-401
Porto
Portugal
/
Departamento de Clínicas Veterinárias, Instituto de Ciências Biomédicas de Abel Salazar (ICBAS)
Universidade do Porto (UP), Rua de Jorge Viterbo Ferreira, nº 228
4050-313 Porto
Portugal
/
CEMUC, Departamento de Engenharia Metalúrgica e Materiais, Faculdade de Engenharia
Universidade do Porto, Rua Dr. Roberto Frias s/n
4200-465 Porto
Portugal


Andrew L. Miller
Division of Life Science and State Key Laboratory of Molecular Neuroscience
HKUST, Clear Water Bay
Hong Kong
China


Antonia Alvarez
Department Cell Biology and Histology, School of Medicine and Enfermery
University of Basque Country
E-48940 Leioa
Spain


Baixia Hao
Division of Life Science and State Key Laboratory of Molecular Neuroscience
HKUST, Clear Water Bay
Hong Kong
China


Beatriz Arteta
Department Cell Biology and Histology, School of Medicine and Enfermery
University of Basque Country
E-48940 Leioa
Spain


Carla Mendonça
Centro de Estudos de Ciência Animal (CECA), Instituto de Ciências
Tecnologias e Agroambiente (ICETA) da Universidade do Porto, Praça Gomes Teixeira, Apartado 55142, 4051-401
Porto
Portugal
/
Departamento de Clínicas Veterinárias, Instituto de Ciências Biomédicas de Abel Salazar (ICBAS)
Universidade do Porto (UP), Rua de Jorge Viterbo Ferreira, nº 228
4050-313 Porto
Portugal


Chen Kan
Department of Pathophysiology, School of Basic Medical Sciences
Anhui Medical University, Hefei
Anhui
China


Daniel McCulloch
School of Medicine
Deakin University
Geelong
Victoria
Australia
/
Centre for Molecular and Medical Research
Deakin University
Geelong
Victoria
Australia


Enrique Hilario
Department Cell Biology and Histology, School of Medicine and Enfermery
University of Basque Country
E-48940 Leioa
Spain


Haimei Lu
Department of Pathophysiology, School of Basic Medical Sciences
Anhui Medical University, Hefei
Anhui
China


Inês Leal Reis
Centro de Estudos de Ciência Animal (CECA), Instituto de Ciências
Tecnologias e Agroambiente (ICETA) da Universidade do Porto, Praça Gomes Teixeira, Apartado 55142, 4051-401
Porto
Portugal
/
Departamento de Clínicas Veterinárias, Instituto de Ciências Biomédicas de Abel Salazar (ICBAS)
Universidade do Porto (UP), Rua de Jorge Viterbo Ferreira, nº 228
4050-313 Porto
Portugal


Jianbo Yue
Department of Biomedical Sciences
City University of Hong Kong
Hong Kong
China


Joana Marquez
Department Cell Biology and Histology, School of Medicine and Enfermery
University of Basque Country
E-48940 Leioa
Spain


José Domingos Santos
CEMUC, Departamento de Engenharia Metalúrgica e Materiais, Faculdade de Engenharia
Universidade do Porto, Rua Dr. Roberto Frias s/n
4200-465 Porto
Portugal


José Rubén García- Montes
Departamento de Neurobiología funcional y de sistemas
Instituto Cajal. Madrid
España



José Miguel Campos
Centro de Estudos de Ciência Animal (CECA), Instituto de Ciências
Tecnologias e Agroambiente (ICETA) da Universidade do Porto, Praça Gomes Teixeira, Apartado 55142, 4051-401
Porto
Portugal
/
Departamento de Clínicas Veterinárias, Instituto de Ciências Biomédicas de Abel Salazar (ICBAS)
Universidade do Porto (UP), Rua de Jorge Viterbo Ferreira, nº 228
4050-313 Porto
Portugal
/
Escola Universitária Vasco da Gama (EUVG)
Hospital Veterinário Universitário de Coimbra (HVUC), Av. José R. Sousa Fernandes, Campus Universitário – Bloco B, Lordemão
3020-210 Coimbra
Portugal


Lijun Chen
Department of Pathophysiology, School of Basic Medical Sciences
Anhui Medical University, Hefei
Anhui
China


Lixin Kan
Department of Pathophysiology, School of Basic Medical Sciences
Anhui Medical University, Hefei
Anhui
China
/
Department of Medical Laboratory Science
Bengbu Medical College, Bengbu
Street no.
Bengbu
Anhui
China
/
Department of Neurology
Northwestern University
Chicago
USA


Luís Miguel Atayde
Centro de Estudos de Ciência Animal (CECA), Instituto de Ciências
Tecnologias e Agroambiente (ICETA) da Universidade do Porto, Praça Gomes Teixeira, Apartado 55142, 4051-401
Porto
Portugal
/
Departamento de Clínicas Veterinárias, Instituto de Ciências Biomédicas de Abel Salazar (ICBAS)
Universidade do Porto (UP), Rua de Jorge Viterbo Ferreira, nº 228
4050-313 Porto
Portugal


René Drucker- Colín
Departamento de Neuropatología Molecular, Instituto de Fisiología Celular
Universidad Nacional Autónoma de México
Ciudad de México


Rui Alvites
Centro de Estudos de Ciência Animal (CECA), Instituto de Ciências
Tecnologias e Agroambiente (ICETA) da Universidade do Porto, Praça Gomes Teixeira, Apartado 55142, 4051-401
Porto
Portugal
/
Departamento de Clínicas Veterinárias, Instituto de Ciências Biomédicas de Abel Salazar (ICBAS)
Universidade do Porto (UP), Rua de Jorge Viterbo Ferreira, nº 228
4050-313 Porto
Portugal


Sarah E. Webb
Division of Life Science and State Key Laboratory of Molecular Neuroscience
HKUST, Clear Water Bay
Hong Kong
China


Sheena Raju
Regenerative Medicine
Reliance Life Sciences Pvt Ltd
Mumbai
India
/
School of Medicine
Deakin University
Geelong
Victoria
Australia


Sílvia Santos Pedrosa
Centro de Estudos de Ciência Animal (CECA), Instituto de Ciências
Tecnologias e Agroambiente (ICETA) da Universidade do Porto, Praça Gomes Teixeira, Apartado 55142, 4051-401
Porto
Portugal
/
Departamento de Clínicas Veterinárias, Instituto de Ciências Biomédicas de Abel Salazar (ICBAS)
Universidade do Porto (UP), Rua de Jorge Viterbo Ferreira, nº 228
4050-313 Porto
Portugal


Wei Seong Toh
Faculty of Dentistry
National University of Singapore
Singapore
/
Tissue Engineering Program, Life Sciences Institute
National University of Singapore
Singapore


Wenjie Wei
Department of Biomedical Sciences
City University of Hong Kong
Hong Kong
China


Yangyang Hu
Department of Pathophysiology, School of Basic Medical Sciences
Anhui Medical University, Hefei
Anhui
China


Zareen Amtul
Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences
University of Karachi
Karachi-75270
Pakistan




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