Solubility, Delivery and ADME Problems of Drugs and Drug-Candidates

by

Karoly Tihanyi , Monika Vastag

DOI: 10.2174/97816080512051110101
eISBN: 978-1-60805-120-5, 2011
ISBN: 978-1-60805-619-4



Indexed in: Book Citation Index, Science (BKCI-S), Web of Science, BIOSIS Previews, Scopus, Chemical Abstracts, EBSCO.

This comprehensive ebook covers all the aspects of ADME/PK modeling including solubility, absorption, formulation, metabolic stability...[view complete introduction]
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Transporterization: A Tool for Drug Delivery to the Central Nervous System

- Pp. 213-228 (16)

Gabor Orgovan and Bela Noszal

Abstract

Drug delivery to the central nervous system (CNS) has long been recognised as an enormous task, due to the physiological gate-keeping function of the blood-brain barrier (BBB). With the development of molecular biology, the function and properties of the BBB are better understood. In this review, transporterization, a promising method for drug delivery by endogenous proteins, is discussed, and a survey of the reported results is presented.

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