Pesticide Chemistry and Toxicology

Book Series: Toxicology: Agriculture and Environment

Volume 1


Dileep K. Singh

DOI: 10.2174/97816080513731120101
eISBN: 978-1-60805-137-3, 2012
ISBN: 978-1-60805-531-9
ISSN: 2589-1480 (Print)
ISSN: 2211-2952 (Online)

Indexed in: Scopus, EBSCO.

Pesticide control involves killing pest organisms or otherwise preventing them from destructive behavior. Pesticides are either natura...[view complete introduction]
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Metabolism or Degradation of Pesticides: Phase I and Phase II Reactions

- Pp. 62-96 (35)

Dileep K. Singh


In this chapter pesticide metabolism has been described. Pesticide Metabolism is typically a two stage process. These are Phase I and Phase II reactions. Phase I reactions normally add a functional (polar reactive) group to the foreign molecule which enables the phase 2 reaction to take place. These reactions are catalyzed by the cytochrome P450 group of enzymes and other enzymes which are associated with endoplasmic reticulum. Phase I reactions includes, Microsomal oxidation and Extramicrosomal oxidation reactions. Phase II reactions are conjugation reactions and involve the covalent linkage of the toxin or phase I product to a polar compound. In general, conjugated products are ionic, polar, less lipid soluble, less toxic and easily excretable from body. </p> <p> All reactions of pesticide metabolism are described using chemical structure with possible target sites and enzyme involved.

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