Anti-Angiogenesis Drug Discovery and Development

Volume 1

by

Atta-ur-Rahman, FRS, M. Iqbal Choudhary

DOI: 10.2174/97816080516251110101
eISBN: 978-1-60805-162-5, 2011
ISBN: 978-1-60805-648-4
ISSN: 2452-3240 (Print)
ISSN: 2210-268X (Online)



Indexed in: Scopus, EBSCO, Ulrich's Periodicals Directory.

The inhibition of angiogenesis is an effective mechanism of slowing down tumor growth and malignancies. The process of induction or pr...[view complete introduction]
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Thymidine Phosphorylase Inhibitors

- Pp. 116-147 (32)

Radim Nencka

Abstract

Thymidine phosphorylase (TP) is an enzyme that acts as a proangiogenic factor. Overexpression of the enzyme was observed in various solid tumors and several chronic inflammatory diseases, where it was correlated with level of angiogenesis and elevated progression of the disease. TP inhibitors are compounds designed to interfere with the processes connected with catalytic function of this enzyme including TP-mediated angiogenesis and the degradation of important antiviral and anticancer drugs. This chapter comprehensively reviews the hitherto known TP inhibitors with further insight into their potential applications in the clinical practices.

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