Frontiers in Drug Design and Discovery

Volume 5

by

Atta-ur-Rahman, Mohammad Iqbal Choudhary

DOI: 10.2174/97816080520351100501
eISBN: 978-1-60805-203-5, 2010
ISBN: 978-1-60805-527-2
ISSN: 1574-0889 (Print)
ISSN: 2212-1064 (Online)



Indexed in: Scopus, EMBASE, EBSCO, Ulrich's Periodicals Directory.

Frontiers in Drug Design and Discovery is a book series devoted to publishing the latest and the most important advances in drug desig...[view complete introduction]
US $
Buy Personal eBook
44
Order Library eBook
176
Order Printed Copy
*139
Order PDF + Printed Copy (Special Offer)
*161

*(Excluding Mailing and Handling)

🔒Secure Checkout Personal information is secured with SSL technology
Download Flyer

Development of Novel Synthetic Hydrophilic Resin for Drug-Protein Interaction Analysis

- Pp. 41-66 (26)

Akito Tanaka and Takao Isogai

Abstract

<p>Functional coupling resins have been used to generate various protein- and ligand-immobilized gels for protein purification, proteomic research, drug development and synthetic biology. Recently, drug-immobilized resins have found broader applications for the analysis of drug-protein interactions, which are interfered with by the drug substances. Non-specific protein binding to the resin, not to the immobilized drug, is a common problem in the characterization of the bound proteins. Many commercial resins have more or less hydrophobic properties, leading to non-specific adsorption of proteins, in particular hydrophobic proteins. In addition, some resins are chemically unstable against the conditions used for drug immobilization: organic solvents are often used in immobilization reactions. We have developed a novel resin with functional amine group. It is a synthetic resin and hence chemically stable, and has a highly hydrophilic surface, minimizing non-specific protein adsorption. In addition, the resin surface can be made even more hydrophilic by surface coating. A couple of examples demonstrate its superior property for characterization of drug-protein interactions.</p>

Purchase Chapter  Book Details

Advertisement


Webmaster Contact: info@benthamscience.net Copyright © 2019 Bentham Science