Chapter 23

Trends in Hit-to-Lead: An Update

Benoit Deprez and Rebecca Deprez-Poulain

Abstract

<p>The goal of this paper is to review the variety of approaches used to improve lead generation, in terms of cost, time and risk management. Our analysis shows that successful lead generation requires not only an accurate definition of the needs (to define the most relevant assay protocols and readouts), but most of all a good hit as a starting point. It also appears that teams where techniques and knowledge are combined, are more successful in that difficult game.</p>

Total Pages: 653-673 (21)

Purchase Chapter  Book Details

RELATED BOOKS

.Botanicals and Natural Bioactives: Prevention and Treatment of Diseases.
.Frontiers In Medicinal Chemistry.
.Alkaloids and Other Nitrogen-Containing Derivatives.
.Potential Health Benefits of Biologically Active Peptides Derived from Underutilized Grains: Recent Advances in their Isolation, Identification, Bioactivity and Molecular Analysis.