Chapter 12

Integral Tissue Participation in Carcinogenesis

Lawrence M. Agius

Abstract

Simple delineation of the evolutionary dynamics of neoplastic growth in contrast with a host of associated biologic events in neoplastic infiltration of stroma and adjacent tissues or the metastatic spread of the tumor cells, bring into prominent profile the diversity of architectural reconstitutive identity of neoplasms in a manner constant with a great diversity of genetic mutability. In this sense, the further progression of injury as genotoxicity proves an underlying demonstrative step in its own right in formulating the characterizations of the carcinogenetic steps in malignant transformation of cells and tissues.

Total Pages: 73-74 (2)

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