Synthesis and Biological Applications of Glycoconjugates

by

Olivier Renaudet, Nicolas Spinelli

DOI: 10.2174/97816080527761110101
eISBN: 978-1-60805-277-6, 2011
ISBN: 978-1-60805-537-1



Indexed in: Chemical Abstracts, Scopus, EBSCO.

The interactions between carbohydrates and proteins have been extensively explored in a wide range of physiological and pathological p...[view complete introduction]
US $
Buy Personal eBook
44
Order Library eBook
176
Order Printed Copy
*143
Order PDF + Printed Copy (Special Offer)
*165

*(Excluding Mailing and Handling)

ūüĒíSecure Checkout Personal information is secured with SSL technology
Download Flyer

Monovalent and Multivalent Glycoconjugates as High Affinity Ligands for Galectins

- Pp. 92-115 (24)

Sebastien Vidal

Abstract

<p>The biological implications of lectins have prompted a large number of research projects at the interface between biology and chemistry for a better understanding of their roles. Several synthetic high affinity ligands have been designed in order to inhibit their negative effects such as bacterial or viral infections and cancer. Among these receptor proteins, galectins are galactose-binding lectins implicated in inflammation or cancer and are important biological targets for the design of treatment against cancer. The careful design of high affinity ligands for galectins has been investigated through several studies using either (1) a ‚Äúmedicinal chemistry‚ÄĚ approach in which the native ligand (i.e. galactose) is modified on one or several positions or (2) based on a multivalent approach in which galactose is repeated n times at the periphery of a core scaffold. Both strategies yielded essential information about the fundamental aspects of galectin-ligand interactions and provided a better knowledge of the implications of galectins in biology. The present review with 130 references will focus particularly on the past decade and present the most recent results obtained in this field for monovalent and multivalent ligands of galectins.</p>

Purchase Chapter  Book Details

Advertisement


Webmaster Contact: info@benthamscience.net Copyright © 2019 Bentham Science