Chapter 9

Free Radicals and Related Reactive Species in Renal Diseases

Y. Robert Li

Abstract

Kidney diseases are broadly classified into acute kidney injury and chronic kidney disease. They collectively affect approximately 10% of the adult population in the United States and worldwide, and represent a major issue of public health. As our understanding of the pathophysiology of kidney diseases becomes more advanced, various new mechanistically-based therapeutic strategies for treating these diseases have been developed. This chapter summarizes experimental and clinical evidence supporting a causative role of oxidative stress in the pathophysiology of both acute kidney injury and chronic kidney disease. It also discusses the recent development of antioxidant-based intervention of kidney disorders.

Total Pages: 202-216 (15)

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