Chapter 10

Free Radicals and Related Reactive Species in Cancer

Y. Robert Li

Abstract

Cancer remains a leading cause of death in the human population worldwide. Both genetic and environmental factors are involved in the development of cancer. Recent work also demonstrates a critical role for reactive oxygen and nitrogen species (ROS/RNS) in multistage carcinogenesis. This chapter examines the oxidative stress mechanism of carcinogenesis as well as antioxidant-based modalities for cancer intervention. The chapter also discusses ROS as a potential tumor killing modality in cancer therapy.

Total Pages: 217-231 (15)

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