Sialobiology: Structure, Biosynthesis and Function Sialic Acid Glycoconjugates in Health and Disease

by

Joe Tiralongo, Ivan Martinez-Duncker

DOI: 10.2174/97816080538651130101
eISBN: 978-1-60805-386-5, 2013
ISBN: 978-1-60805-067-3



Indexed in: Scopus, EBSCO.

This eBook presents a summary of central aspects of sialobiology (i.e., the study of sialic acid and its relevance to biology). The im...[view complete introduction]
US $
Buy Personal eBook
89
Order Library eBook
356
Order Printed Copy
*206
Order PDF + Printed Copy (Special Offer)
*250

*(Excluding Mailing and Handling)

🔒Secure Checkout Personal information is secured with SSL technology
Download Flyer

Synthesis of Sialic Acid-Containing Oligosaccharides and Sialylmimetics

- Pp. 404-447 (44)

Sadagopan Magesh and Hiromune Ando

Abstract

Chemical construction of α-glycoside of sialic acid (Sia) is a demanding subject due to the structural disadvantages of sialic acid: the carboxylate group at C1, the deoxy moiety adjacent to the anomeric center, and the glycerol branch from C6. Since Meindl and Tuppy reported the first synthesis of the glycoside of Sia in 1965, the development of stereoselective sialylation has been the subject for intensive efforts. The first part of this chapter will overview the classical methods for sialylation which override the disadvantages and introduce the cutting-edge of methods for α-selective sialylation, exemplifying the stereoselective synthesis of sialyl oligosaccharides. The later part will briefly summarize several strategies used for the design of sialylmimetics and their potential for the development of sialo-pharmaceuticals in treating various human disease states.

Purchase Chapter  Book Details

Advertisement


Webmaster Contact: info@benthamscience.net Copyright © 2019 Bentham Science