Translational Animal Models in Drug Discovery and Development

by

Xinkang Wang

DOI: 10.2174/97816080546951120101
eISBN: 978-1-60805-469-5, 2012
ISBN: 978-1-60805-591-3



Indexed in: Scopus, EBSCO.

Animal models of diseases play a pivotal role in drug discovery and development, not only for proof of the concept studies of efficacy...[view complete introduction]
US $
Buy Personal eBook
49
Order Library eBook
196
Order Printed Copy
*119
Order PDF + Printed Copy (Special Offer)
*143

*(Excluding Mailing and Handling)

🔒Secure Checkout Personal information is secured with SSL technology
Download Flyer

Animal Models of Ischemic Stroke: Issues in Translational Congruency

- Pp. 42-66 (25)

Frank C. Barone, Daniel M. Rosenbaum, Jie Li, Jin Zhou and Xinkang Wang

Abstract

Stroke is a leading cause of death and disability worldwide. Effective intervention for acute stroke remains to be a significant unmet medical need. In the past several decades, a large number of therapeutic-pharmacological agents have been evaluated in preclinical models with many advancing to late stages of clinical study. However, all potential interventions (with the exception of the approval of early thrombolysis using recombinant tissue plasminogen activator; tPA) have failed. To address this translational gap, a series of meetings by the Stroke Therapy Academic Industry Roundtable (STAIR) has conducted and has made recommendations over the past decade in order to provide guidance to the stroke research community in the development of novel stroke therapeutic interventions. In spite of these efforts, large clinical studies have continued to fail. This chapter describes the most commonly used preclinical stroke models that have been applied to novel drug discovery, including critiques and translational perspectives of their advantages and limitations. Furthermore, novel biomarkers are used in stroke intervention research, including the monitoring of salvageable brain tissue as a therapeutic index of potential protection. For example, the measurement of the ischemic penumbra is discussed as an important means to more accurately assess and translate the efficacy of therapeutic agents from animal models to man.

Purchase Chapter  Book Details

Advertisement


Webmaster Contact: info@benthamscience.net Copyright © 2019 Bentham Science