Immunology of Pregnancy 2013


Gérard Chaouat, Olivier Sandra, & Nathalie Lédée

DOI: 10.2174/97816080573371130101
eISBN: 978-1-60805-733-7, 2013
ISBN: 978-1-60805-734-4

Indexed in: EBSCO.

Since a September, 1992, Nature article which read: “Can there be life without LIF?”, researchers now realize that the maternal immune...[view complete introduction]
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Immuno Endocrine Interactions: An Example; Progestagen Treatment for Threatened and Recurrent Abortion and Molecular Mechanisms

- Pp. 614-624 (11)

Julia Szekeres-Bartho, Melinda Halasz, Beata Polgar and Agnes Bogdan


Progesterone supplementation has been used as a treatment for threatened miscarriage to prevent spontaneous pregnancy loss. Although a plethora of key functions and pathways affected by progesterone have been identified, there are still not sufficient diagnostic methods to precisely identify the groups of patients that would benefit from progesterone-treatment. We review the progesterone-induced genes and pathways, which control the process of endometrial receptivity as well as decidualization, and shape the immunological microenvironment at the materno-fetal interface. Recent clinical data suggest a possible beneficial effect of progesterone in the therapy of threatened miscarriage; still, further, larger, randomized controlled trials on the effect of progestogens on the treatment of threatened miscarriage are needed.

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