Probing Intracellular Regulation

Book Series: Advances in Genome Science

Volume 2

by

Christian Neri

DOI: 10.2174/97816080575661130201
eISBN: 978-1-60805-756-6, 2013
ISBN: 978-1-60805-757-3
ISSN: 2213-6606 (Print)



Indexed in: EMBASE, EBSCO.

Genome science or genomics is essential to advancing knowledge in the fields of biology and medicine. Specifically, resea...[view complete introduction]
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Mechanisms and Signals for the Nuclear Import of Proteins

- Pp. 77-100 (24)

Natália Freitas and Celso Cunha

Abstract

In eukaryotes, the nuclear membrane provides a physical barrier to the passive diffusion of macromolecules from and into the cytoplasm. Nucleocytoplasmic traffic occurs through highly specialized structures known as nuclear pores, and involves the participation of a special class of transport proteins. Active transport across the nuclear pores is an energy-dependent process that relies on the activity of Ran- GTPases both in the nuclear and cytoplasmic compartments. </p><p> Nuclear import of proteins is an essential step in regulating gene expression and the replication cycle of several viruses. In this review, the key mechanisms, pathways, and models underlying the transport of proteins across nuclear pores are analysed.

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