Chapter 1

Angiotensin Blockers and Renoprotection in Diabetic Chronic Kidney Disease is a Failed Paradigm? – A Revisionist View of Renoprotection in Diabetic Chronic Kidney Disease and A Novel Classification Scheme for Renoprotective Agents

Macaulay A.C. Onuigbo

Abstract

The excellent innovative work of Squibb Laboratory scientists in the 1970’s led to the discovery of the ACE inhibitors and the ARBs. Despite their widespread use, for renoprotection, we have continued to experience a global ESRD pandemic. Angiotensin blockade has proved inadequate. In 2010, we asked the rhetorical question: Is renoprotection with RAAS blockade a failed paradigm?

Total Pages: 3-32 (30)

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