Heat Shock Response Agents and the Diseases
- Pp. 139-160 (22)Lütfi Tutar, Aykut Özgür, Esen Tutar, Kübra Açıkalın Coşkun and Yusuf Tutar
Heat shock proteins (Hsps) are highly conserved proteins and have cytoprotective role for maintaining cellular protein conformation. Hsps not only keep proteins in their native state but also involve in several essential biochemical process. This review summarizes structural properties of Hsps (Hsp70, Hsp40, Hsp90, Hsp100, Hsp60, sHsps, and Nucleotide Exchange Factors) and explains their roles in aging, apoptosis, cancer, neurodegeneration, cardio-vascular diseases, obesity and diabetes mellitus, and housekeeping.