Frontiers in Anti-Cancer Drug Discovery

Volume 3


Atta-ur-Rahman, M. Iqbal Choudhary

DOI: 10.2174/97816080588461140301
eISBN: 978-1-60805-884-6, 2014
ISBN: 978-1-60805-885-3
ISSN: 2451-8395 (Print)
ISSN: 1879-6656 (Online)

Indexed in: EMBASE, EBSCO, Ulrich's Periodicals Directory.

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Nitric Oxide as an Adjuvant Therapeutic in the Clinical Management of Cancer

- Pp. 191-200 (10)

Nicole J. Kenote, Tysha N. Medeiros, Dana M. Jarigese, Melissa A. Edwards and Mark A. Brown


The ability of tumors to develop resistance to cytotoxic therapies has been a major obstacle in the clinical management of cancer. In addition, dose-limiting toxicity represents yet another impediment in the application of traditional therapeutics. To enhance the sensitivity of tumors to radio-therapeutics, researchers are increasingly turning to nitric oxide for its potential as a powerful adjuvant to existing therapies. Here, we review the aptitude of nitric oxide to serve as a radio-sensitizing, adjuvant therapeutic for the clinical management of cancer.

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