Frontiers in Anti-Cancer Drug Discovery

Volume 3

by

Atta-ur-Rahman, M. Iqbal Choudhary

DOI: 10.2174/97816080588461140301
eISBN: 978-1-60805-884-6, 2014
ISBN: 978-1-60805-885-3
ISSN: 2451-8395 (Print)
ISSN: 1879-6656 (Online)



Indexed in: EMBASE, EBSCO, Ulrich's Periodicals Directory.

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Nitric Oxide as an Adjuvant Therapeutic in the Clinical Management of Cancer

- Pp. 191-200 (10)

Nicole J. Kenote, Tysha N. Medeiros, Dana M. Jarigese, Melissa A. Edwards and Mark A. Brown

Abstract

The ability of tumors to develop resistance to cytotoxic therapies has been a major obstacle in the clinical management of cancer. In addition, dose-limiting toxicity represents yet another impediment in the application of traditional therapeutics. To enhance the sensitivity of tumors to radio-therapeutics, researchers are increasingly turning to nitric oxide for its potential as a powerful adjuvant to existing therapies. Here, we review the aptitude of nitric oxide to serve as a radio-sensitizing, adjuvant therapeutic for the clinical management of cancer.

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