Topics in Anti-Cancer Research

Volume 3


Atta-ur-Rahman / Khurshid Zaman

DOI: 10.2174/97816080590891140301
eISBN: 978-1-60805-908-9, 2014
ISBN: 978-1-60805-909-6
ISSN: 2468-5860 (Print)
ISSN: 2213-3585 (Online)

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Indexed in: Book Citation Index, Science (BKCI-S), Chemical Abstracts, BIOSIS Previews, EBSCO, Ulrich's Periodicals Directory.

This is the third volume of the Patent eBook Series entitled Topics in Anti-Cancer Research. This eBook comprises updated reviews on t...[view complete introduction]
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Table of Contents


- Pp. i-iv (4)
Atta-ur-Rahman and Khurshid Zaman
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List of Contributors

- Pp. v-vi (2)
Atta-ur-Rahman and Khurshid Zaman
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- Pp. vii
Atta-ur-Rahman and Khurshid Zaman
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TRAIL Receptor-Induced Cell Death Regulation: An Update to Our Deadly Discussion

- Pp. 3-36 (34)
Olivier Micheau, Sarah Shirley and Alexandre Morizot
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Novel Inhibitors of Inosine Monophosphate Dehydrogenase as Potential Anti-Cancer Drugs: A Patent Review (2002-2014)

- Pp. 37-102 (66)
Riccardo Petrelli, Ilaria Torquati, Krzysztof Felczak, Daniel J. Wilson and Loredana Cappellacci
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Current and Future Medical Therapy, and the Molecular Features of Adrenocortical Cancer

- Pp. 103-150 (48)
Agata Jabrocka-Hybel, Dorota Pach, Aleksandra Gilis-Januszewska, Grzegorz Sokołowski and Alicja Hubalewska-Dydejczyk
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Therapeutic Strategies Targeting Glioblastoma Stem Cells

- Pp. 151-178 (28)
Estefania Carrasco-Garcia, Nicolas Sampron, Paula Aldaz, Olatz Arrizabalaga, Jorge Villanua, Cristina Barrena, Irune Ruiz, Mariano Arrazola, Charles Lawrie and Ander Matheu
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Calcium Signaling and Angiogenesis

- Pp. 179-201 (23)
Luca Munaron
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<i>Ganoderma lucidum</i>: A Potential for Biotechnological Production of Anti-Cancer and Immunomodulatory Drugs

- Pp. 202-271 (70)
Bojana Boh
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New Gene Therapy Strategies for Cancer Treatment: A Review of Recent Patents

- Pp. 272-318 (47)
Raúl Ortiz, Consolación Melguizo, José Prados, Pablo J. Álvarez, Octavio Caba, Fernando Rodríguez-Serrano, Fidel Hita and Antonia Aránega
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Molecular Dynamic Studies Unveil Potential Mechanisms of Resistance to Imatinib in BCR-ABL Mutants

- Pp. 319-341 (23)
Tai-Sung Lee, Steven J. Potts and Maher Albitar
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Application of Hyperthermia for Cancer Treatment: Recent Patents Review

- Pp. 342-383 (42)
Paulaes I.P. Soares, Isabel M.M. Ferreira and João P.M.R. Borges
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The Na<sup>+</sup>-H<sup>+</sup> Exchanger (NHE1) in pH Regulation and Cancer

- Pp. 384-417 (34)
Stephan J. Reshkin, Rosa A. Cardone, Katrine Zeeberg, Maria R. Greco and Salvador Harguindey
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Expanding Targets for a Metabolic Therapy of Cancer: LAsparaginase

- Pp. 418-445 (28)
Daniele Covini, Maristella Maggi, Saverio Tardito, Ovidio Bussolati, Laurent R. Chiarelli, Maria V. Pasquetto, Luca Vecchia, Giovanna Valentini and Claudia Scotti
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Aryl- and Heteroaryl-Thiosemicarbazone Derivatives and Their Metal Complexes: A Template for Pharmacological Activities

- Pp. 446-483 (38)
Narayana S.H.N. Moorthy, Nuno M.F.S.A. Cerqueira, Maria J. Ramos and Pedro A. Fernandes
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Proteome-Based Anti-Tumor Cell Therapy

- Pp. 484-529 (46)
Andrey S. Bryukhovetskiy, Valeriy E. Shevchenko, Sergey V. Kovalev, Vladimir G. Polyakov, Igor S. Bryukhovetskiy and Maria V. Zhukova
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Antineoplastic Action of Growth Hormone-Releasing Hormone (GHRH) Antagonists

- Pp. 530-551 (22)
Agnieszka Siejka, Hanna Lawnicka, Gabriela Melen-Mucha, Ewelina Motylewska, Jan Komorowski and Henryk Stepien
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New Tamoxifen-based Strategies in Cancer Research

- Pp. 552-580 (29)
Claudia Rivera-Guevara, Alma Y. Vázquez-Sánchez and Javier Camacho
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Recent Advances in Anti-Telomerase Cancer Therapy

- Pp. 581-631 (51)
Apurva Agrawal, Shweta Dang and Reema Gabrani
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Author Index

- Pp. 632-633 (2)
Atta-ur-Rahman and Khurshid Zaman
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Subject Index

- Pp. 634-658 (25)
Atta-ur-Rahman and Khurshid Zaman
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This is the third volume of the Patent eBook Series entitled Topics in Anti-Cancer Research. This eBook comprises updated reviews on topics relevant to modern cancer research published in the journal Recent Patents on Anti-Cancer Drug Discovery.

The comprehensive range of themes covered in this third volume will be of benefit to clinicians, scientists and R&D expertslooking for new targets for the prevention of cancer and discovery of drugs for the treatment of different cancer types. Regulation of tumor cells by TRAIL receptors, development of anti- cancer drugs & immunomodulatory drugs, molecular studies of adrenocortical cancer, role of inhibitors of inosine monophosphate dehydrogenase in cancer, recent updates in glioblastoma stem cells, latest approaches for cancer gene therapy and metabolic therapy for cancer were reviewed and updated. The role of pH regulation and application of hyperthermia, thiosemicarbazone derivatives, tamoxifen-based therapies for cancer treatment andproteome-based complex therapy of tumors, calcium signaling and angiogenesis, antineoplastic role of GHRH antagonists and therapeutic applications in human tumors and clinical oncology have been extensively discussed in the light of recent innovations.

The topics covered in this third volume will be valuable for those researchers interested in new methods for the prevention of cancer as well its management.

Micheau et al. discuss updated innovations and information the role of TRAIL/APO2L and TRAIL -Induced Cell Death regulation in cancer therapy. These studies will be of great interest for researchers working in the area of apoptosis and TRAIL receptors DR4 and DR5 (death receptors).

In the second chapter, Petrelli et al. present chemical structures and biological activities of Inosine Monophosphate Dehydrogenase inhibitors (IMPDH) as a target enzyme and as potential anti-cancer drugs. Patents filed in the three major classes of IMPDH are discussed.

Hubalewska-Dydejczyk et al. address genetic and molecular mechanisms of adrenocortical cancer, which are helpful to study the pathology and assessment of molecular markers. This chapter provides interesting information about the latest and promising new therapies for adrenocortical cancer carcinoma treatment.

Chapter 4 by Matheu et al. focuses on the treatment approaches targeting glioblastoma stem cells (GSCs) and also covers glioblastoma cell biology and glioblastoma therapy.

Munaron summarizes recent advances in the area of calcium signaling (Orai/STIM and angiogenesis including properties and function of the intracellular calcium signals (Cai) engaged in the management of vascular endothelial cells (ECs).

Pharmacological activities of Ganodema lucidum are reviewed by Boh in Chapter 6 with focuses on anti-cancer and immunomodulatory properties of this traditional Chinese medicinal Basidiomycete mushroom in the light of patents and scientific articles. Cultivation methods, group of active compounds from polysaccharides, triterpenoids and glycoproteins, and composition of anti-cancer formulations with clinical trials are thoroughly discussed.

Prados et al. have presented the use of reformed vectors and state of art cancer gene therapy strategies, patented clinical or pre-clinical trials in Chapter 7. Different patented processes involved in these approaches based on gene therapy are covered.

Comprehensive study of molecular dynamics (MD) simulations of Imatinib resistance causing T3151 and other mutations in BCR-ABL kinase are reviewed by Lee et al. Findings on the analysis based on dynamic simulations, drug protein interactions and mechanism of drug resistance at the atomic level will be beneficial for the design of new drugs to overcome resistance.

Chapter 9 by Ferreira et al. provides recent and patented literature on the applications of intracellular hyperthermia for cancer treatment. Concepts based on nanotechnology and those without nanotechnology methodologies are categorized. The role of magnetic nanoparticles for the detection and diagnosis of tumors is also reviewed.

Reshkin et al., in Chapter 10 review the latest patented developments for understanding the mechanism of Na+- H+ (NHE1), anti-NHE1pharmacological approaches, use of combined therapy including NHE1 inhibition, and Na+- H+ (NHE1) exchangers in pH regulation for cancer therapy and tumor biology.

Scotti et al. focus on antitumor activity of enzyme L-asparginase (ASNase) for developing targets for a molecular cancer therapy and metabolic pathways particularly with reference to patents on biotechnological procedures for the production of ASNase and use of L-asparginase in chemotherapy.

In Chapter 12, Moorthy et al. have presented an overview of the current patented progress for reviewing pharmacological and chelation properties of aryl- /heteroarylthiosemicarbazone derivatives and their metal complexes. Limitaions and toxic effects of thiosemicarbazone derivatives ware also discussed.

Maria et al. describe a comparative oncoproteomic study of neural stem/progenitor cells from U87 glioblastoma cell lines, detection of signalling pathways based on the results of proteome mapping categorization of proteins by HPLC and Mass Spectrometry analysis and identification of proteomic signatures specific for tumor cells and transduction pathway.

In Chapter14, Stepien et al. have presented an overview of the current patented developments and antineoplastic action of Growth Hormone-Releasing Hormone (GHRH) antagonists in human cancers. The role of synthetic GHRH antagonists attributing inhibitory effects on tumor growth has also been reviewed in this chapter.

Camacho et al. present a review on Tamoxifen and its patented analogs and the use of Tamoxifen-based strategies in cancer research. The authors have discussed the mechanism of action of estrogen receptor (ER) dependent and ER independent actions of estrogen and provide information on SNPs associated to the endocrine therapy along with some clinical trials.

Gabrani et al. inChapter 16provide a complete overview of recent patents and patent applications in anti-telomerase cancer therapy. The authors have discussed tumor specific anti-telomerase compounds based on the mechanism of action and target components of the human telomerase enzyme including antisense-oligonucleotides, hammerhead ribozymes, dominant negative human telomerase reverse transcriptase (DN- hTERT), reverse-transcriptase inhibitors, immunotherapy, G-quadruplex stabilisers, gene therapy, small molecule inhibitors and RNA interference.

We anticipate that the third volume will be of great interest to a large number of clinicians, cancer scientists, R&D experts, researchers, medical doctors, pharmacologists and medicinal chemists, pursuing new targets for the prevention & treatment of cancer and for the development of potential cancer inhibitors, targets and anti-cancer drugs.

The editors wish to extend their thanks to Mr. Mahmood Alam, Mrs. Rafia Rehan, the reviewers, the authors, friends and all colleagues for their contribution and providing support in the finalization of the eBook.

Atta-ur-Rahman, FRS
Kings College
University of Cambridge


Khurshid Zaman
Bentham Science Publishers

List of Contributors

Atta-ur-Rahman / Khurshid Zaman
University of Cambridge

Bojana Boh
University of Ljubljana
Faculty of Natural Sciences and Engineering
Askerceva 12

Javier Camacho
Department of Pharmacology
Avenida Instituto Politécnico Nacional 2508.,
Centro de Investigación y de Estudios Avanzados del I.P.N.

Isabel M.M. Ferreira
CENIMAT/I3N, Departamento de Ciência dosMateriais
Faculdade de Ciências e Tecnologia, FCT, Universidade Nova de Lisboa

Reema Gabrani
Department of Biotechnology
Jaypee Institute ofInformation Technology,
A- 10, Sector- 62
Uttar Pradesh, 201307

Alicja Hubalewska-Dydejczyk
Department of Clinical Endocrinology,
Jagiellonian University, Medical College
ul. Kopernika 17, 31-501

Ander Matheu
Head of Neuroncology Group
Biodonostia Institute
Paseo Dr. Begiristain s/n, E-20014 San Sebastian

Olivier Micheau
INSERM, Faculty of Medicine and Pharmacy
University of Bourgogne
U866, Dijon, F-21079

Narayana S.H.N. Moorthy
REQUIMTE, Departamento de Química eBioquímica
Faculdade de Ciências,
Universidade do Porto, s/n
Rua do Campo Alegre, 4169-007 Porto

Luca Munaron
Department of Life Sciences & Systems Biology
Center for Complex Systems in Molecular Biology
and Medicine (SysBioM) Nanostructured Interfaces and Surfaces Centre of Excellence (NIS)
University of Torino, Italy, Via Accademia Albertina 13,10123

Riccardo Petrelli
School of Pharmacy
University of Camerino,
via S. Agostino 1, 62032
Camerino (MC)

José Prados
Institute of Biopathology and Regenerative Medicine (IBIMER),
Department of Anatomy and Embryology, School of Medicine,
University of Granada, 18071

Stephan J Reshkin
Department of Bioscience
Biotechnology and Biopharmaceutics, University of Bari
Bari, 70126

Claudia Scotti
Department of Molecular Medicine
Unit of Immunology andGeneral Pathology, University of Pavia, Via Ferrata, 9
Pavia, 27100

Henryk Stepien
Department of Immunoendocrinology
Chair of Endocrinology, Medical University of Lodz, ul. Sterlinga 3, 91-425

Tai-Sung Lee
Department of Chemistry and Chemical Biology
Center for Integrative Proteomics Research
Rutgers University, 174 Frelinghuysen Rd
NJ, 08854-8076

Maria V. Zhukova
NeuroVita Clinic of Restorative and Interventional Neurology and Therapy
23 Kashirskoe Shosse
Moscow, 115478


Review 1

“…of benefit to clinicians, scientists and R&D experts looking for new targets for the prevention of cancer and discovery of drugs… …valuable for those interested in scientists interested in methods for the prevention of cancer as well its management.” – Professor Q. Ping Dou, Departments of Oncology, Pharmacology and Pathology, Wayne State University

Published in Current Cancer Drug Targets Current Cancer Drug Targets, Volume 15 - Number 3, May 2015


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